Award Data

This pilot study is aimed at judging the efficacy of the lead compound with a clinically relevant allergenThe relevant allergen chosen for this study is the house dust mite Dermatophagoides pteronyssinus allergenDer pLoToxTM Natural Der pfrom Indoor Biotechnologies with a low endotoxin contentEUgWe are selecting this allergen because our team has extensive prior experience with this allergen in mo ...

This Small Business Innovation Research Phase II project will develop a commercially viable device that uses micro scale acoustic streaminglow frequency sound energyto deliver mixing to the interior of three dimensionalDscaffolds used for stem cell cultivation applicationsThe enabling advantage of low frequency sound energy is the ability to generate micro scale mixing in and around scaffolds that ...

PROJECT SUMMARY Resective neurosurgery is essential for treating a range of neurologic conditions such as epilepsy and brain tumorsFor some patientswhose lesion is close to cortical language areaspostoperative expressive or receptive language deficit is a major and feared postoperative complicationMuch effort is devoted to identifying the cortical language regionsand relating such localization to ...

PROJECT SUMMARY The objective of our program is to develop a safe and effective nonopioid analgesic for the treatment of neuropathic painsuch as pain associated with chemotherapy induced peripheral neuropathythat targets an isoform of the voltage gated sodium ion channelNaVVoltage gated sodium channels are involved in the transmission of nociceptive signals from their site of origin in the periphe ...

Project Summary The aim of the present SBIR program is to develop a new noninvasivepoint of care testing device for patients undergoing treatment for substance use disorderThe new device will be capable of monitoring the progress and verifying patient adherence to prescribed treatment by detecting the presence and level of a compounded adherence marker released in the urineproviding for the first ...

ABSTRACT Fungal keratitisprimarily caused by CandidaFusariumor Aspergillus speciesis a leading cause of blindness among corneal diseasesAmphotericin BAmBremains the gold standard in the treatment of Candida keratitis and is also the fallback option for other corneal fungal infectionsAlthough widely used off label in ocular infectionsophthalmic AmB formulations are not available commerciallyThe com ...

SPECIFIC AIMSAntibiotic resistance among common bacterial pathogens is a serious public health problem as it compromises our ability to treat infectious diseaseThe resistance problem is compounded by the relative lack of discovery of new antibioticsespecially those with novel mechanisms of actionNew antibiotics are critically needed as resistance to recently developed antibiotics is growingThe goa ...

Project SummaryThere are currently no approved vaccines for most emerging biological pathogensEbolaChikungunyaMERS CoVSARSZikaopportunistic infectionsSaureusCandidiasisadenovirusor potential bioterrorism agentsYpestisBPseudomalleiFtularensisBunyaviridaeFlaviviridaeand therapeutic interventions such as antibiotics and antivirals are only effective for a select few pathogensA promising approach for ...

Development Process for Production of Natural THC and CBD AbstractTetrahydrocannabinolTHCand cannabidiolCBDare two major constituents of the cannabis plant that have pharmacological properties with potential therapeutic value in several disease conditionsWhileTHC has already been in use clinically for two indicationsnausea and vomiting in cancer patients receiving chemotherapy and appetite stimula ...

This Small Business Innovation Research Phase I project will develop a prototype and then evaluate a novel device that utilizes low frequency sound energy to enhance cell culture productivityThe acoustic micromixing generated by the proposed device is compatible with cells and possesses the capability to substantially enhance the culture efficiency of cells cultured in typical culture vesselsThis ...