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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Discovery of new small molecule TLR4 agonists for the treatment of allergic rhinitis

    SBC: DiaCarta, Inc.            Topic: NIAID

    This pilot study is aimed at judging the efficacy of the lead compound with a clinically relevant allergenThe relevant allergen chosen for this study is the house dust mite Dermatophagoides pteronyssinus allergenDer pLoToxTM Natural Der pfrom Indoor Biotechnologies with a low endotoxin contentEUgWe are selecting this allergen because our team has extensive prior experience with this allergen in mo ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Acoustic Scaffold Bioreactor

    SBC: RESODYN CORPORATION            Topic: NHLBI

    This Small Business Innovation Research Phase II project will develop a commercially viable device that uses micro scale acoustic streaminglow frequency sound energyto deliver mixing to the interior of three dimensionalDscaffolds used for stem cell cultivation applicationsThe enabling advantage of low frequency sound energy is the ability to generate micro scale mixing in and around scaffolds that ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Noninvasive Functional Cortical Mapping with Innovative tEEG

    SBC: CREmedical Corp            Topic: 106

    PROJECT SUMMARY Resective neurosurgery is essential for treating a range of neurologic conditions such as epilepsy and brain tumorsFor some patientswhose lesion is close to cortical language areaspostoperative expressive or receptive language deficit is a major and feared postoperative complicationMuch effort is devoted to identifying the cortical language regionsand relating such localization to ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Discovery of NaV1.7 Inhibitors for the Treatment of Pain

    SBC: Siteone Therapeutics, Inc.            Topic: 105

    PROJECT SUMMARY The objective of our program is to develop a safe and effective nonopioid analgesic for the treatment of neuropathic painsuch as pain associated with chemotherapy induced peripheral neuropathythat targets an isoform of the voltage gated sodium ion channelNaVVoltage gated sodium channels are involved in the transmission of nociceptive signals from their site of origin in the periphe ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Adherence Monitor for Substance Use Disorder Treatment

    SBC: YELLOWSTONE SCIENTIFIC INSTRUMENTS            Topic: NIDA

    Project Summary The aim of the present SBIR program is to develop a new noninvasivepoint of care testing device for patients undergoing treatment for substance use disorderThe new device will be capable of monitoring the progress and verifying patient adherence to prescribed treatment by detecting the presence and level of a compounded adherence marker released in the urineproviding for the first ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Improving treatment options and outcomes in fungal keratitis

    SBC: TranZ Biosciences LLC            Topic: N

    ABSTRACT Fungal keratitisprimarily caused by CandidaFusariumor Aspergillus speciesis a leading cause of blindness among corneal diseasesAmphotericin BAmBremains the gold standard in the treatment of Candida keratitis and is also the fallback option for other corneal fungal infectionsAlthough widely used off label in ocular infectionsophthalmic AmB formulations are not available commerciallyThe com ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Novel antibacterial agents derived from natural products

    SBC: Promiliad Biopharma Incorporated            Topic: NIAID

    SPECIFIC AIMSAntibiotic resistance among common bacterial pathogens is a serious public health problem as it compromises our ability to treat infectious diseaseThe resistance problem is compounded by the relative lack of discovery of new antibioticsespecially those with novel mechanisms of actionNew antibiotics are critically needed as resistance to recently developed antibiotics is growingThe goa ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Novel synthetic TLR4 agonists

    SBC: INIMMUNE CORP            Topic: NIAID

    Project SummaryThere are currently no approved vaccines for most emerging biological pathogensEbolaChikungunyaMERS CoVSARSZikaopportunistic infectionsSaureusCandidiasisadenovirusor potential bioterrorism agentsYpestisBPseudomalleiFtularensisBunyaviridaeFlaviviridaeand therapeutic interventions such as antibiotics and antivirals are only effective for a select few pathogensA promising approach for ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Development of a Process for GMP Production of Natural THC and CBD

    SBC: ElSohly Laboratories, Incorporated            Topic: R41

    Development Process for Production of Natural THC and CBD AbstractTetrahydrocannabinolTHCand cannabidiolCBDare two major constituents of the cannabis plant that have pharmacological properties with potential therapeutic value in several disease conditionsWhileTHC has already been in use clinically for two indicationsnausea and vomiting in cancer patients receiving chemotherapy and appetite stimula ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Acoustic Enhanced Cell Culture

    SBC: RESODYN CORPORATION            Topic: 400

    This Small Business Innovation Research Phase I project will develop a prototype and then evaluate a novel device that utilizes low frequency sound energy to enhance cell culture productivityThe acoustic micromixing generated by the proposed device is compatible with cells and possesses the capability to substantially enhance the culture efficiency of cells cultured in typical culture vesselsThis ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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