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DESCRIPTION provided by applicant A Phase II SBIR program of preclinical development is proposed for the development of an active specific immunotherapeutic called Cellariumandquot for treatment of glial cell based cancers Successful completion of this project will confirm therapeutic effect and pre clinical safety of the vaccine in preparation for first in human studies Upon demonstration of ...

DESCRIPTION provided by applicant Therapeutics based on nucleic acids NA promise to revolutionize treatment of multiple diseases but their widespread use is currently limited by the lack of efficient delivery methods We have recently developed a new NA delivery platform based on polymeric CXCR inhibitors PCX suitable as dual function systems for simultaneous NA delivery and inhibition of ...

DESCRIPTION provided by applicant Low level tumor associated somatic DNA mutations can have profound implications for development of metastasis prognosis choice of treatment follow up or early cancer detection Unless they are effectively detected these low level mutations can misinform patient management decisions or become missed opportunities for personalized medicine Widely used tech ...

DESCRIPTION provided by applicant The avian origin H N influenza virus that emerged in humans in China in presents a unique challenge to vaccine development because it is poorly immunogenic Neutralizing antibodies are not detected in acute phase infection Anti H antibody responses are significantly delayed and exhibit low avidity in comparison with antibodies generated following seas ...

DESCRIPTION provided by applicant Systemic sclerosis scleroderma SSc is a chronic autoimmune disease characterized by proliferative vascular lesions with resultant fibrosis of skin and other multiple organs including the gastrointestinal GI tract In the United States the prevalence of SSc is about per million in adults Up to of SSc patients are reported to have upper and lower ...

ABSTRACT Pancreatic cancer PC is an extremely aggressive malignancy with one of the worst prognoses of all cancers with a median survival of less than one year and an overall year survival of andlt With marked resistance to chemo and radiotherapies surgery is the only curative option In patients with localized disease and no lymph node or extra pancreatic metastases complete surgical ...

DESCRIPTION provided by applicant Breast cancer is the most common type of cancer in women between the ages of and and responsible for deaths annually If treated early five year survival rates for patients in the U S are between and but drop to once metastatic breast cancer has developed Thus there is a great need to develop more effective treatment strategies fo ...

DESCRIPTION provided by applicant This Small Business Innovation Research project aims to develop an innovative eye drop formulation for the treatment of diabetic retinopathy The goal of this proposal is to develop substantial efficacy safety and pharmacokinetic data to support the clinical development of topical fenofibrate We hypothesize that topical application of fenofibrate can reduce ...

Abstract Pancreatic ductal adenocarcinoma PDAC is a devastating cancer with an extremely low year survival rate even for those who are diagnosed early Novel research suggests that this may be the result of metastatic dissemination preceding or concurrent to the development of the primary tumor Epithelial mesenchymal transition EMT is one of the key pathways in pancreatic cancer invasion ...

To apply a novel technology platform to the development of a Toxoplasma gondii vaccine