Award Data

Necrotizing enterocolitis (NEC) is a devastating acute inflammatory condition of the gastrointestinal tract resulting in intestinal necrosis, systemic sepsis and multi-system organ failure found mostly in infants born prematurely. Despite modern medical advances in the past decade, the etiology remains elusive and morbidity and mortality are still unacceptably high. It has been concluded that the ...

Perinatal brain injury resulting in mental retardation and cerebral palsy is the most severe disability in children and affects 40-148 in preterm and 1–2/1000 in full term infants. This places a huge burden on society, emphasizing the critical need for improved prevention/treatment strategies to decrease perinatal brain injury. Hypothermia (HT) is the only FDA approved therapy to attenuate brain ...

The TONE Knows Inc. ("TONE") will develop next-generation warehouse inventory management, verification, location, and reconciliation utilizing our patented "audio QR Code" technology. This technology allows for the continuous monitoring, tracking, and accounting for every single item stored in a DLA DC, external storage areas, in-theater Distribution Centers, or forward storage facilities, util ...

Abstract Duchenne Muscular Dystrophy (DMD) is a fatal muscle disease with an incidence of 1 in 5000 males. DMD results from mutations in the gene encoding dystrophin, a 427 kDa scaffolding protein responsible for providing a mechanical link between the muscle fiber actin cytoskeleton and laminin in the extracellular matrix. The α7β1 integrin is a transmembrane linkage system in skeletal and card ...

The conventional nitric acid manufacturing method uses natural gas as a feedstock for hydrogen and an energy intensive thermal process that emits a large amount of carbon dioxide. A new low-temperature plasma system, which can be driven electrically by a renewable or nuclear energy source, could reduce the energy consumed by the synthesis of nitric acid while eliminating the emission of greenhouse ...

PROJECT ABSTRACT Although rt11 million family/friends are caregivers to rt6 million people with Alzheimer's Disease (AD) and AD- Related Dementias (AD/ADRD), they do not typically receive personalized education, strategies and support to manage their own wellbeing and complex dementia-related symptoms. Lack of personalized care contributes to $321 billion annually in AD/ADRD care costs. In respons ...

Summary Climate change is an urgent public health threat, and climate-related health risks disproportionately impact vulnerable populations. Public health agencies have underscored the need to develop scalable and innovative health-equity centered, multi-level interventions that offer tools and resources to 1) raise awareness of the inextricable link between climate change and health and 2) suppor ...

Annular extruded plastics are in everything from fuel lines, hoses, pipes, and wires to catheters, medical tubing, and stents and makes up about ? of the $200B extruded plastics market. Extrusion manufacturing is a major processor of the $600B raw plastics industry, which produces 380 million metric tons of material each year. The production of these materials accounts for 4% of oil consumption an ...

The national imperative to field hypersonic weapon systems has increased the demand for robust, lightweight, and affordable high temperature materials for thermal protection systems.  Refractory composites such as carbon-carbon (C/C) or carbon/SiC (C/SiC) offer enormous promise, but wider-scale acceptance continues to be hindered by certain technical and affordability limitations.  Key among the ...

Municipal Solid Waste (MSW) is a huge untapped renewable feedstock resource to produce hydrogen through gasification. Currently, the utilization MSW for hydrogen production is not realized due to the presence of chlorine that causes degradation of gasifier components and formation of pollutants during gasification. This proposed technology has the potential to remove chlorine and produce a consist ...