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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Novel Therapy for Hyperphosphatemic Familial Tumoral Calcinosis (hfTC) and Generalized Hyperphosphatemia

    SBC: FGF Therapeutics INC.            Topic: NIAMS

    Abstract Hyperphosphatemic familial tumoral calcinosis (hfTC) is a disease in which patients cannot produce the bioactive form of the hormone Fibroblast growth factor-23 (FGF23), which is secreted by osteocytes to rid the body of phosphate by acting on the kidney. hfTC is characterized by markedly elevated serum phosphate (Pi) which causes large intramuscular calcifications to develop. The calcifi ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  2. Preclinical evaluation of SERCA2 allosteric activators for pancreatic β-cell protection in diabetes.

    SBC: NEURODON, LLC            Topic: NIDDK

    The overall goal of this collaborative project between Neurodon and Indiana University School of Medicine is the development of compounds that will offer disease-modifying treatments for type 1 (T1D) and type 2 diabetes (T2D) mellitus, a sorely unmet need. In this initial STTR project, we will use our expertise in medicinal chemistry, cell biology, and diabetes pathophysiology to functionally test ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  3. The Butterfly BVM, a Novel Resuscitator to Prevent Hyperventilation in Pediatric Resuscitation

    SBC: COMPACT MEDICAL INC.            Topic: NICHD

    PROJECT SUMMARY Bag-valve-mask (BVM) resuscitators are difficult to use correctly and are commonly misused, even by trained medical personnel. Misuse can result in serious injury and death due to volutrauma or barotrauma, and this is particularly concerning when resuscitating pediatric patients, in whom there is an extreme range in lung volume. Traditional BVMs provide no adequate means of restric ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  4. Virtual Reality Facilitation of Recovery from Opioid Use Disorder

    SBC: RELATE XR, LLC            Topic: NIDA

    PROJECT SUMMARY / ABSTRACT This Phase I project is a pilot randomized clinical trial designed to show commercial potential for a novel virtual reality intervention in preparation for Phase II development. We propose testing our adjunctive intervention for efficacy on reducing opioid use and increasing abstinence in early recovering opioid use disorder (OUD) persons, with concomitant increases in s ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  5. From Academia to Business: Development of Novel Therapeutics Against HPV-Associated Cancer

    SBC: Kovina Therapeutics Inc.            Topic: NCI

    ABSTRACT “High-risk” human papillomavirus (HPV) types such as 16 (HPV-16) are identified in the majority of HPV- associated pre-malignant and malignant pathologies of cervical, anogenital, and oropharyngeal epithelia. The E6 protein is essential for viral replication. Structure-based computational screening followed by design and synthesis of derivatives led to the identification of a series o ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  6. SnapCap: a device to decontaminate central venous catheters (CVC) with 5 snaps

    SBC: Contech Medical, Inc.            Topic: NICHD

    Project Summary/Abstract We propose a new approach to the decontamination of central venous catheters and the prevention of central line-associated bloodstream infections (CLABSI), an important healthcare-associated infection. CLABSIs cost the US healthcare system approximately $2.3 billion annually (Pronovost, NEJM, 2009). Additionally, CLABSIs can be life threatening, especially in the very youn ...

    STTR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
  7. Development of a Digital Cognitive Screening Test to detect Mild Cognitive Impairment and Dementia in Clinical Settings.

    SBC: EchoWear LLC            Topic: NIA

    Project Summary Alzheimer’s disease and related dementias are a growing health problem in our aging population. Assessment of cognitive functioning for early detection is critical to identify individuals who might benefit from treatment with the available symptomatic medications for mild dementia as well as future disease-modifying therapies that are actively under development and being tested i ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  8. New Treatments for Glaucoma

    SBC: GRANNUS THERAPEUTICS, INC.            Topic: NEI

    Abstract Aggregation of mutated myocilin (MYOC), a protein found in the endoplasmic reticulum (ER) of trabecular meshwork (TM) cells, disrupts the outflow of aqueous humor from the eye, causing increase in intraocular pressure (IOP), progressive retinal ganglion cell (RGC) death, and degeneration of the optic nerve, leading to primary open-angle glaucoma (POAG), characterized by irreversible visio ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  9. Promoting adult hippocampal neurogenesis in Alzheimer's Disease using an antibody-based therapy

    SBC: BOLDEN THERAPEUTICS, INC.            Topic: R

    PROJECT SUMMARY Alzheimer's disease (AD) is a looming public health crisis that threatens millions of patients' ability to experience healthy aging. In addition to the challenges that AD poses to patients, healthcare providers and caregivers, there is also tremendous economic burden associated with AD and related dementias – estimated to be well over $200B/year in the United States alone. Hundre ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  10. Development of Innovative Medical Device Technology for Quantifying Forces during Soft Tissue Manipulation Assessment and Intervention

    SBC: Health Smart Technologies, Inc            Topic: R

    PROJECT SUMMARY The lack of a means to quantify soft tissue manipulation (STM) motion and dose as delivered in the clinic is a critical problem in the reproducibility and therapeutic potential of this non-invasive and non-pharmacological modality. STM is a form of manual therapy used to evaluate and treat musculoskeletal pain, inflammation, and dysfunction. Different soft tissue forces have differ ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
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