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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Biocatalytic production of precursors to lutein and zeaxanthin to address age related macular degeneration

    SBC: EscaZyme Biochemicals, LLC            Topic: N

    Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Therapeutic TRPA Mechanism Based Treatment of Chemotherapeutic Induced Neuropathic Pain

    SBC: ALGOMEDIX, INC.            Topic: 102

    Abstract Cancer patients treated with many widely used chemotherapeutic agents including paclitaxel PAC and oxaliplatin OXA frequently develop chemotherapy induced peripheral neuropathy CIPN that may lead to dose reduction dosing schedule changes and termination of treatment In some patients acute peripheral neuropathy PN can transition into chronic PN lasting well beyond termination ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Rational drug selection for Alzheimer s disease using Indicator Cell Assay Platform iCAP

    SBC: PreCyte Inc            Topic: NIA

    Project Summary We are developing a novel tool for disease diagnosis called the indicator cell assay platform iCAP that uses standardized cultured cells as biosensors to detect disease status of patients from blood or cerebral spinal fluid CSF samples Here we propose to establish proof of concept for applying the assay to drug discovery by initiating development of the iCAP for drug selectio ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Clinical Study of an Extended Patency Dialysis Access Graft

    SBC: HEALIONICS CORPORATION            Topic: 300

    Clinical Study of an Extended Patency Dialysis Access Graft PROJECT SUMMARY Objective The goals of this PAR Clinical Studies Fast Track SBIR proposal are to move a novel hemodialysis access graft design to k submission and upon k clearance conduct a patient clinical study to demonstrate improved performance compared to current synthetic grafts which have high rate of clot ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. A Nanopatterned Interdigitated Electrode Array Device for Anti migratory Cancer Drug Screening

    SBC: NANOSURFACE BIOMEDICAL, INC.            Topic: 102

    PROJECT SUMMARY As the cancer drug industry suffers from the lowest success rate in developing cancer cure drugs cell migration assessment assays that evaluate the transition of cells from a benign to a metastatic phenotype have gained more attention Given the fact that metastatic cancer cells are substantially harder to eradicate than those that are benign migratory propensity is now understoo ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Ultra Bright Fluorescent Probes for Flow Cytometry

    SBC: LAMPROGEN INC            Topic: 100

    Project Summary For modern flow cytometry high throughput multiplexing is extremely important because of the great need in analyzing a large number of biomolecules on and in a single cell The multiplexing performance of flow cytometry is hindered by the probe performance including their fluorescence brightness and emission bandwidth However there is renewed interest and effort to develop high ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Development of a Proteogenomic Search Engine for Direct Mass Spectrometric Identification of Variant Proteins Using Genomic Data

    SBC: SPECTRAGEN INFORMATICS, LLC            Topic: 102

    Project Summary Abstract Next generation sequencing NGS technologies are uncovering a wealth of information regarding genetic differences at the DNA level These differences can be either inheritable or occur in somatic cells during the course of an individualandapos s lifetime In rare but important cases these differences occur in coding regions giving rise to mutated protein forms Such p ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Early Detection of Ovarian Cancer Using Uterine Lavage and Duplex Sequencing

    SBC: Twinstrand Biosciences, Inc.            Topic: 102

    Early Detection of Ovarian Cancer Using Uterine Lavage and Duplex Sequencing Nearly a quarter of a million new cases of ovarian cancer are identified every year worldwide and the majority of these woman will die from their disease When detected early surgical cure rates exceed but currently most cases are detected at an advanced stage when the cancer has already disseminated As such our m ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. A high throughput sample preparation platform for genomic and epigenetic analysis

    SBC: Matchstick Technologies Inc.            Topic: 200

    Several types of cancers e g pancreatic and brain malignancies remain extremely lethal despite the introduction of chemotherapy more than years ago The hallmark of all cancers are somatic mutations which cannot be corrected In sharp contrast epigenetic changes essential contributors to tumorigenesis are pharmacologically reversible The ability to remedy detrimental epigenetic alteratio ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. A Novel Probiotic for the Treatment of Rheumatoid Arthritis

    SBC: VIRTICI LLC            Topic: NIAMS

    Project Summary Our goal is to develop a novel L lactis probiotic based therapeutic for the treatment of rheumatoid arthritis RA RA is a chronic systemic inflammatory disorder affecting as much as worldwide and as much as of the US population The exact frequencies depend on geographical origin and gender women being three times more affected than men While many organs are affecte ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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