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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Commercialization of a Rapid Blood Test for Traumatic Brain Injury

    SBC: Fawkes Biotechnology, LLC            Topic: 100

    Traumatic brain injuryTBIis a substantial health care issue affecting both civilian and military populationsAlthough extremes of head injury are recognizablemild to moderate TBImmTBIis more difficult to diagnose leading to a need for the identification of circulating biomarkers of brain injury that may facilitate early identificationUsing a rat model of TBI we identified a novel marker of neuronal ...

    STTR Phase I 2018 Department of Health and Human Services
  2. PLGA encapsulated polyphenols to ameliorate IBD.

    SBC: THERAPYX, INC.            Topic: R

    Abstract Green tea has received increased attention recentlydue to several epidemiological and clinical studies showing a positive relationship between consumption and disease preventionBenefits include reduced risk of cardiovascular diseasese gmyocardial infarctionhypertensionatherosclerosisneurodegenerative diseasese gParkinson s and Alzheimer s diseaseand certain cancerse ggastricbreast and cer ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. Exploiting activation-induced cell death as a means of inducing tolerance to kidney allografts

    SBC: FasCure Therapeutics LLC            Topic: NIAID

    PROJECT SUMMARY Kidney transplantation is the preferred treatment for patients with end stage renal diseaseHoweverstandard immunosuppression to control rejection is the major limitationAlthough standard immunosuppression has gradually been improved for better efficacy and safetyit still carries a great risk for adverse effects ranging from malignancies and infections to cardiovascular complication ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. mHealth for Patient Self-Management of Opioid Use Disorder

    SBC: Biomedical Development Corporation            Topic: 104

    Opioid abuse has become an epidemic with devastating healthsocialand economic consequences for the United StatesDrug overdose deaths have nearly tripled fromDuringdrug overdoses accounted forU Sdeathsincludingthat involved an opioidopioid pain relievers and heroinOpioid analgesic overdose is now the leading cause of injury death in the U Sinthere were approximately one and a half times more drug o ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. A Novel Lipotherapy to Reduce Infarct Size Following Myocardial Infarction

    SBC: ENDOPROTECH, INC.            Topic: NHLBI

    According to the CDC inischemic heart disease is the leading cause of death worldwideand in the US approximatelypatients died of ischemic heart diseaseIt is well established in clinical practice that recanalization of the infarct related arteryIRAusing percutaneous coronary interventionPCIenhances myocardial salvage and outcomes in patients with ST segment elevation myocardial infarctionSTEMIWhen ...

    SBIR Phase II 2018 Department of Health and Human Services
  6. Stage-Based Mobile Intervention for Substance Use Disorders in Primary Care: Implementation and Cluster-Randomized Trial

    SBC: Pro-Change Behavior Systems Inc            Topic: NIDA

    Nearlymillion Americans ageand olderneed treatment for a substance use disorderSUDWhile onlyof individuals requiring treatment for a SUD receive itan estimated two thirds see a primary care or urgent care provider everymonthsPrimary care providers are in a unique position to perform ScreeningBrief Interventionand Referral to TreatmentSBIRTWith Phase I contract fundingPro Change developed and pilot ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. A cost-effective robotic platform for on-demand production of flexibly dosed medications in a chewable gummy dosage form

    SBC: Vitae Industries, Inc.            Topic: NICHD

    PROJECT SUMMARYThis project s goal is to develop an innovative cost effective robotic platform for fast on demand pharmacy production of pediatric drugs as individually tailored palatable gummy dosage formsMedication adherence is notoriously low among children due to difficulty swallowing pills and rejection of bad tasting medicationsAlthough some common pediatric drugs have flavored liquid formsp ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. Caring for the Caregiver: A Theory-Driven Mobile Intervention to Promote Caregiver Well-Being

    SBC: Pro-Change Behavior Systems Inc            Topic: NIA

    Overmillion Americans are currently providing unpaid care to a family memberrelativeor friend with Alzheimer s disease or related dementiaWhile caregiving can be a positive experience that brings meaning and an increased sense of purposeit can also take a tollNearlyof Alzheimer s and dementia caregivers rate their emotional distress as high or very highand as many assuffer from depressionCaregiver ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. Mimicking synuclein toxicity in plant cells to identify novel neuroprotective leads

    SBC: NAPROGENIX, INC.            Topic: NINDS

    Abstract Alpha synucleinASYNis believed to play an important role in the pathology of several neurodegenerative conditionsincluding some forms of Parkinsonandapos s diseaseDementia with Lewy Bodiesand Multiple Systems AtrophyThe most recent hypothesis is that the ASYN proteinsparticularly genetic variants such as AT that are prone to misfoldingare cleaved by the lysosomal enzymeasparagine endopept ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. Rapid Test to Assist Therapy in Neonatal Sepsis and Necrotizing Enterocolitis

    SBC: PROTHERA BIOLOGICS, LLC            Topic: R

    The primary goal of this proposed research is to develop a rapid point of care test that assesses the risk of neonatal sepsisNSand or necrotizing enterocolitisNECin infants based on Inter alpha inhibitor proteinsIAIPlevels in bloodThe test is expected to be simpleuser friendlyportable and suitable for use in the NICUNS and NEC are associated with high mortality and morbidityincluding adverse neuro ...

    SBIR Phase I 2018 Department of Health and Human Services

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