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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Adherence Monitor for Substance Use Disorder Treatment

    SBC: YELLOWSTONE SCIENTIFIC INSTRUMENTS            Topic: NIDA

    Project Summary The focus of the present SBIR program is to determine the feasibility of a new noninvasivepoint of care testing device for patients undergoing treatment for substance use disorderThe new device will be capable of monitoring the progress and verifying adherence with patient treatment regimen by detecting the presenceand levelof a compounded adherence marker released in the urineprov ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. Stage-Based Mobile Intervention for Substance Use Disorders in Primary Care: Implementation and Cluster-Randomized Trial

    SBC: Pro-Change Behavior Systems Inc            Topic: NIDA

    Nearlymillion Americans ageand olderneed treatment for a substance use disorderSUDWhile onlyof individuals requiring treatment for a SUD receive itan estimated two thirds see a primary care or urgent care provider everymonthsPrimary care providers are in a unique position to perform ScreeningBrief Interventionand Referral to TreatmentSBIRTWith Phase I contract fundingPro Change developed and pilot ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. A cost-effective robotic platform for on-demand production of flexibly dosed medications in a chewable gummy dosage form

    SBC: Vitae Industries, Inc.            Topic: NICHD

    PROJECT SUMMARYThis project s goal is to develop an innovative cost effective robotic platform for fast on demand pharmacy production of pediatric drugs as individually tailored palatable gummy dosage formsMedication adherence is notoriously low among children due to difficulty swallowing pills and rejection of bad tasting medicationsAlthough some common pediatric drugs have flavored liquid formsp ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. Topical selective T-type blockers for the treatment of neuropathic pain

    SBC: Dermaxon LLC            Topic: 105

    Project SummaryAbstract Paclitaxel is widely used throughout the field of oncology with indications for the treatment of a number of solid tumorsThe most commonly reported neurotoxic effect of paclitaxel is peripheral sensory neuropathy which often limits the dose and frequency of paclitaxel treatmentNeuropathic pain management is currently aimed only at reducing symptoms and treatment of chronic ...

    STTR Phase I 2018 Department of Health and Human Services
  5. Caring for the Caregiver: A Theory-Driven Mobile Intervention to Promote Caregiver Well-Being

    SBC: Pro-Change Behavior Systems Inc            Topic: NIA

    Overmillion Americans are currently providing unpaid care to a family memberrelativeor friend with Alzheimer s disease or related dementiaWhile caregiving can be a positive experience that brings meaning and an increased sense of purposeit can also take a tollNearlyof Alzheimer s and dementia caregivers rate their emotional distress as high or very highand as many assuffer from depressionCaregiver ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. Integrating CNV analysis into a NextGen sequencing clinical analytics platform

    SBC: Golden Helix, Inc.            Topic: 400

    Abstract The goal of this project is to develop a commercial analysis software platform that features the ability to detect and interpret copy number variantsCNVsand other types of structural variationsSVsfrom short read NextGen SequenceNGSdata to enable comprehensivewidely accessibleand economical genetic testingThis capability is key in clinical and research applicationsFor examplecurrently clin ...

    SBIR Phase II 2018 Department of Health and Human Services
  7. Rapid Test to Assist Therapy in Neonatal Sepsis and Necrotizing Enterocolitis

    SBC: PROTHERA BIOLOGICS, LLC            Topic: R

    The primary goal of this proposed research is to develop a rapid point of care test that assesses the risk of neonatal sepsisNSand or necrotizing enterocolitisNECin infants based on Inter alpha inhibitor proteinsIAIPlevels in bloodThe test is expected to be simpleuser friendlyportable and suitable for use in the NICUNS and NEC are associated with high mortality and morbidityincluding adverse neuro ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. Live Cell Assays to Identify and Interrogate Stressed Neurons in Models of Neurodegenerative Disease.

    SBC: Montana Molecular LLC            Topic: 105

    Summary Abstract Many diseases of the brain involve cellular stressEarly in lifethe Zika virus triggers stress in neural progenitor cells causing microcephalyMuch later in life the mutant proteins produced in Parkinsonandapos s and Huntingtonandapos s diseaseas well as ALSand Alzheimerandapos s all produce cellular stress leading to the slow neurodegeneration that occurs over many yearsTypically t ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. Improving STEM learning through digital technology simulating authentic research

    SBC: MEADOWLARK SCIENCE AND EDUCATION, LLC            Topic: 500

    Novel and effective techniques for imparting STEM based knowledge and concepts are increasingly in demand as our world becomes progressively computerized and complexWhile traditional teaching approaches have worked well in the past for many areas of studyresearch has shown that traditional teaching methods may diminish student engagement in scientific studieswhich are especially dynamic and consta ...

    STTR Phase I 2018 Department of Health and Human Services
  10. Selective inhibition of CYP26A1 in the skin for the treatment of ichthyosis

    SBC: Dermaxon LLC            Topic: NIAMS

    Project SummaryAbstract DermaXon s project goal is to develop efficacious substrate based and highly selective inhibitors of CYPsthe enzymes responsible or retinoic acidRAmetabolism in the epidermisfor the topical treatment of ichthyosisThis approach will provide a therapeutic advantage in ichthyosis without the potential adverse effects mediated by non targeted Pinhibitionassociated with previous ...

    SBIR Phase II 2018 Department of Health and Human Services

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