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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. An integrated mobile and web-based application for problem cannabis use

    SBC: Checkup and Choices LLC            Topic: NIDA

    The objective of this research project is to develop an integrated set of digital tools that will deliver a brief motivational interventionBMIfor young adult marijuana users across a variety of platformsWe havein four randomized clinical trialsdemonstrated the effectiveness of similar tech based interventions for problem drinkingThese interventions have been integrated into one comprehensive progr ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. A high throughput next generation sequencing (NGS) pipeline to generate high quality recombinant therapeutic antibodies

    SBC: Specifica Inc.            Topic: 100

    Abstract Therapeutic antibodies are used to treat many different diseasesincluding cancerauto immunityinfection and atherosclerosisThey are the fastest growing class of pharmaceuticalswith annual revenues of$B inOne of the most important methods to select therapeutic antibodies is by selection from vast antibody librariesHowevergood libraries are extremely challenging to produceand commercially av ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. Stage-Based Mobile Intervention for Substance Use Disorders in Primary Care: Implementation and Cluster-Randomized Trial

    SBC: Pro-Change Behavior Systems Inc            Topic: NIDA

    Nearlymillion Americans ageand olderneed treatment for a substance use disorderSUDWhile onlyof individuals requiring treatment for a SUD receive itan estimated two thirds see a primary care or urgent care provider everymonthsPrimary care providers are in a unique position to perform ScreeningBrief Interventionand Referral to TreatmentSBIRTWith Phase I contract fundingPro Change developed and pilot ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. A cost-effective robotic platform for on-demand production of flexibly dosed medications in a chewable gummy dosage form

    SBC: Vitae Industries, Inc.            Topic: NICHD

    PROJECT SUMMARYThis project s goal is to develop an innovative cost effective robotic platform for fast on demand pharmacy production of pediatric drugs as individually tailored palatable gummy dosage formsMedication adherence is notoriously low among children due to difficulty swallowing pills and rejection of bad tasting medicationsAlthough some common pediatric drugs have flavored liquid formsp ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. Caring for the Caregiver: A Theory-Driven Mobile Intervention to Promote Caregiver Well-Being

    SBC: Pro-Change Behavior Systems Inc            Topic: NIA

    Overmillion Americans are currently providing unpaid care to a family memberrelativeor friend with Alzheimer s disease or related dementiaWhile caregiving can be a positive experience that brings meaning and an increased sense of purposeit can also take a tollNearlyof Alzheimer s and dementia caregivers rate their emotional distress as high or very highand as many assuffer from depressionCaregiver ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. Rapid Test to Assist Therapy in Neonatal Sepsis and Necrotizing Enterocolitis

    SBC: PROTHERA BIOLOGICS, LLC            Topic: R

    The primary goal of this proposed research is to develop a rapid point of care test that assesses the risk of neonatal sepsisNSand or necrotizing enterocolitisNECin infants based on Inter alpha inhibitor proteinsIAIPlevels in bloodThe test is expected to be simpleuser friendlyportable and suitable for use in the NICUNS and NEC are associated with high mortality and morbidityincluding adverse neuro ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. Overcoming Isoniazid Resistance in Tuberculosis with New Chemical Entitites

    SBC: SpinCeutica, Inc.            Topic: NCHHSTP

    Isoniazid resistance is a major problem worldwideespecially the high level resistance caused by ST KatG mutationWe have found a stable isotope substitution improves activity against this resistant strainwhile others have used long acyl hydrazides that also improve activityWe therefore hypothesize that combining long acyl chain hydrazides to drive ST KatG binding with our MIE enhancedacylC INH warh ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. SnapCap: a device to decontaminate central venous catheters (CVC) with 5 snaps

    SBC: Contech Medical, Inc.            Topic: NICHD

    Project Summary Abstract We propose a new approach to the decontamination of central venous catheters and the prevention of central line associated bloodstream infectionsCLABSIan important healthcare associated infectionCLABSIs cost the US healthcare system approximately $billion annuallyPronovostNEJMAdditionallyCLABSIs can be life threateningespecially in the very young and critically illEven whe ...

    STTR Phase I 2018 Department of Health and Human Services
  9. Galectin-1 Protein Therapy for Congenital Muscular Dystrophy


    Abstract Lamininrelated congenital muscular dystrophyLAMACMDalso known as Merosin Deficient Congenital Muscular DystrophyMDC Ais a fatal muscle wasting disease that affects patients from birthLAMACMD results from mutations in the LAMAgene resulting in loss of lamininproteinLamininis required for the formation of the heterotrimers lamininand lamininwhich are major constituents of the skeletal and c ...

    STTR Phase I 2018 Department of Health and Human Services
  10. Transdermal H2S Sensing Device for Monitoring Peripheral Artery Disease

    SBC: EXHALIX, LLC            Topic: NHLBI

    Project Summary Abstract Peripheral artery diseasePADand small vessel diseaseSVDare the consequences of damage to the endothelial cells that line all vesselsboth leading to inadequate skin perfusion and end organ and limb damageIt is prevalent in diabetic patient population in which nearlysuffers from PAD and SVDThe proposed effort addresses an unmet need for early diagnosis of PAD and SVD in this ...

    SBIR Phase II 2018 Department of Health and Human Services

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