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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Indoor Navigation Aid for Individuals with Visual Impairments in Unfamiliar Spaces

    SBC: Vortant Technologies, LLC.            Topic: na

    This project develops a technology solution to address the indoor navigation needs experienced by people with visual disabilities. This technology has several advantages over other wayfinding approaches such as GPS, in that it requires no infrastructure in indoor spaces nor does it require maps to be created prior to navigation. Thus, it is applicable to any unfamiliar indoor or outdoor space. The ...

    SBIR Phase II 2018 Department of Health and Human Services
  2. Web Based Application to Promote Workplace Health Through Behavioral Design

    SBC: Innovation Research And Training, Inc.            Topic: ODCDC

    Healthy design features in a workplace can enable healthy eating and physical activitywhich are key behaviors in the prevention of obesity and other chronic diseasesAs of yetthere is no comprehensive webbased tool for designers and employers in different types of workplacesparticularly small business settingsto learn about and implement behavioral design strategies in the workplaceThe goal of this ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. Topic 377: Enabling Clinical Decision Support for Guideline Based Cancer Symptom Management

    SBC: KLESIS, LLC            Topic: NCI

    The objective of this proposal is to develop an electronic, rule-based clinical decision support system (CDS-Sx) that leverages national clinical practice guidelines (CPGs) to improve cancer symptom management. Specific tasks that will be performed include: 1) create software-ready computable algorithms for managing cancer-related fatigue and constipation that have been vetted with diverse cancer ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Topic 374: Targeted and Sustained Release Microparticles for Colon Cancer Chemoprevention

    SBC: Zymeron Corporation            Topic: NCI

    Colorectal Cancer (CRC) is the third most common cancer both in men and women, as well as the second leading cause of cancer deaths with an estimated 135,430 new cases diagnosed and 50,260 deaths for 2017 in the United States. Given the limitations of screening tests and poor prognosis associated with advanced stage colorectal cancer, it would be of great interest in exploring chemoprevention stra ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. High-throughput methyltransferase assays using recombinant nucleosome substrates

    SBC: EPICYPHER, INC.            Topic: 400

    PROJECT SUMMARYHistone methyltransferasesHMTsare a group of enzymes that represent a critical focal point in the linkage of cellular signals to the regulation of gene expressionThese proteins are not only strongly associated with numerous diseasese gcancersneurodegenerative diseasesand autoimmune disordersbut also have properties that make them excellent targets for drugsThusHMTs provide an except ...

    SBIR Phase II 2018 Department of Health and Human Services
  6. Fully integrated single cell imaging and RNA-Seq library preparation

    SBC: Cell Microsystems, Inc.            Topic: 172

    Project SummaryAmong the commercially available systems for single cell isolation and next generation sequencingNGSsample preparationnone are capable of automating both imaging and NGS sample preparation at high throughputWhile single cell genomic analysis has improved in sensitivity and throughputconcomitant improvements in detailed phenotypic characterization of cells has not been integrated int ...

    SBIR Phase II 2018 Department of Health and Human Services
  7. Rapid Baseline Free Organophosphate Exposure Diagnostic Test

    SBC: Countervail Corporation            Topic: 105

    AbstractThe prolific worldwide misuse of organophosphateOPpesticidescoupled with a grave homeland security concern that OP based nerve agents may be deployed either against our troops or civilians on our home soilhas stimulated the search for rapidminiaturized and inexpensive point of carePOCdiagnostic devices for first responders and medical personnel to detect the degree of OP exposureIdentifica ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. Testing a male oral contraceptive targeting Eppin

    SBC: Eppin Pharma Inc            Topic: NICHD

    The global contraceptives market was valued at $billion inand is expected to grow at a CAGR offromtoto reach an estimated value of $billion inThe contraceptive market consists of short term methods such as condoms and oral contraceptionlong term methods including implants and IUDsand permanent methods such as tubal ligations and vasectomiesEppin Pharmaandapos s product has a unique set of characte ...

    STTR Phase II 2018 Department of Health and Human Services
  9. Development of a Designer Proline-rich antimicrobial peptide Chaperone protein inhibitor (DPC) for treating multi-drug resistant wound infections

    SBC: Arrevus, Inc.            Topic: NIAID

    Project SummaryOver $billion is spent annually in the US treating chronicnon healing woundsmany of which face lifethreatening complications due to infectionsWound infections are difficult to treat due to the frequency of antibiotic resistance as well as the formation of biofilmsa community of bacteria covered by an extracellular polymeric substanceBiofilm related infections can result in a substan ...

    STTR Phase I 2018 Department of Health and Human Services
  10. Innovative TME-specific Pro-CAR T-cells for Immunotherapy of Solid Tumors

    SBC: Panacise Bio, Inc.            Topic: 102

    Abstract This project seeks to develop the next generation pro CARs that are inactive in normal tissues but selectively activated in the tumor microenvironmentTMEThe project is based on our previous development of a novel class of chimeric antigen receptors on the basis of single domain antibody mimics that recognize ErbB family membersSDAErbBon the surface of cancer cellsWe propose two specific a ...

    STTR Phase I 2018 Department of Health and Human Services

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