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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. sHLA Protein Chip

    SBC: GENOMICS USA, INC.            Topic: NIAID

    AbstractsHLA Protein ChipThe class IABCand class II HLA proteinsDRBDQDPcomprise the heart of the inducible human immune systemFor organmarrow and stem cell transplantationthe development of serum born antibodies against one or more of those many HLA proteins comprises the best and earliest test for transplant rejectionBecause of the enormous medical importance of transplantationserum testing for t ...

    SBIR Phase II 2018 Department of Health and Human Services
  2. Development of Taenia Solium Specific Aptamers for Diagnostic Assays

    SBC: Lynntech Inc.            Topic: ODCDC

    The parasitic tapeworm Taenia solium causes two diseasestaeniasisadult worm in the intestineand cysticercosistissue infection by the cystwhich can lead to seizuresThe Tsolium life cycle involves both humans and pigshowever humans are the only definitive host for the adult Tsolium tapewormDiagnosing people infected with the adult worm is a critical step toward eliminating Tsolium althogetherHowever ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. Topic 346: Targeted Radionuclide Therapy of Neuroendocrine Tumors Using 212Pb-octreotate Analogs

    SBC: RADIOMEDIX, INC.            Topic: NCI

    A peptide receptor radionuclide therapy (PRRT) using [177Lu]/[90Y]-labeled somatostatin analogs has been proven to induce objective response in 30-45% of patients with advanced/progressive neuroendocrine tumors (NETs). The complete response to beta-emitter PRRT is rare. This is due to the fact that NETs are diagnosed at late stage of disease; the NETs patients with remissions could develop resista ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Topic 379: Extensible and Scalable Platform for Data Integration from Wearable Sensors to Generate Novel Analytics for Cancer Patients

    SBC: Litmus Health, Inc.            Topic: NCI

    The longterm objective of the Litmus Health platform is to allow researchers and clinicians to use data on cancer patients from wearables/sensors and smartphones. Collecting real-time, high-quality data from patients will transform care and clinical trials. Automating data collection, storage, analysis, and interpretation of data will result in better measurement of signs and symptoms and improved ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Topic 372: Highly multiplexed selection of aptamers to hundreds of canine immunotherapy targets

    SBC: Base Pair Biotechnologies, Inc.            Topic: NCI

    The preclinical development of cancer therapeutics, including the recent trend and focus on cancer immunotherapies, is evolving from the traditional use of mouse models to the use of other animal models including canine, rat, and minipig. Each of these non-mouse models carries its own advantages and abilities to increase the clinical relevance of the model as compared to mouse models. Yet, the wid ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Polyketide chiral building blocks and biocatalysts

    SBC: Coala Biosciences            Topic: 300

    PROJECT SUMMARY As with most synthetic chemistsCoALA Biosciences is inspired by naturally occurring polyketide assembly lineswhich synthesize diverse medicines through reactions that generate carbon carbon bonds and precisely set stereocentersIf chemists were to collaborate with the enzymes in these assembly linessyntheses of compounds in the drug discovery process would be greatly accelerated and ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. Improving Patient Outcomes through Tracking and Displaying the Disinfection Status of Equipment and Area

    SBC: Xenex Disinfection Services Inc.            Topic: 600

    Inhealthcare associated infectionsHAIswere reported in the United StatesDaily and terminal disinfection of hospital areas such as patient rooms are critically important to help prevent HAI and involve extensive disinfection of the room before a new patient is admitted to the roomAdditionallyportable medical equipmentPMEhas been implicated in outbreaks of HAIs and the importance of systematic disin ...

    SBIR Phase II 2018 Department of Health and Human Services
  8. Small molecule Inhibitors of steroid receptor coactivator to treat breast cancer

    SBC: Coactigon, Inc.            Topic: 102

    ABSTRACTSteroid Receptor CoactivatorSRCis a key breast cancer oncogene that is frequently overexpressed or amplified in estrogen receptorERand human epidermal growth factor receptorHERpositive breast cancersElevated expression of SRCalso has been associated with resistance to tamoxifen therapy and with poor disease outcome in HERpositive breast cancersNumerous studies have shown that experimental ...

    STTR Phase I 2018 Department of Health and Human Services
  9. Next Generation All Solid State NASS Lithium Batteries for Implantable Devices

    SBC: Lynntech Inc.            Topic: R

    PROJECT SUMMARY Implantable Cardioverter DefibrillatorsICDand Cardiac Resynchronization Therapy DevicesCRT Dare exclusively powered by non rechargeable lithium primary batteriesand will eventually need to be replaced because of energy depletioneven if all the other components last indefinitelyDevice replacement can result in infection and electrical lead failurewhich are probably the most serious ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. Unified Process for the Discovery of Protein Biomarkers and their X-Aptamer Affinity Reagents

    SBC: AM BIOTECHNOLOGIES, LLC            Topic: 400

    ABSTRACTReflecting a particular physiological statebiomarkers are very important for earlier diagnosis of diseasesrealizing personalized medicineas well as facilitating drug development and discoveryFor these reasonssignificant research efforts are currently being directed towards biomarker discovery and transitioning them into clinical useAM Biotech is developing a new discovery proteomics platfo ...

    SBIR Phase I 2018 Department of Health and Human Services

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