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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Stage-Based Mobile Intervention for Substance Use Disorders in Primary Care: Implementation and Cluster-Randomized Trial

    SBC: Pro-Change Behavior Systems Inc            Topic: NIDA

    Nearlymillion Americans ageand olderneed treatment for a substance use disorderSUDWhile onlyof individuals requiring treatment for a SUD receive itan estimated two thirds see a primary care or urgent care provider everymonthsPrimary care providers are in a unique position to perform ScreeningBrief Interventionand Referral to TreatmentSBIRTWith Phase I contract fundingPro Change developed and pilot ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. A cost-effective robotic platform for on-demand production of flexibly dosed medications in a chewable gummy dosage form

    SBC: Vitae Industries, Inc.            Topic: NICHD

    PROJECT SUMMARYThis project s goal is to develop an innovative cost effective robotic platform for fast on demand pharmacy production of pediatric drugs as individually tailored palatable gummy dosage formsMedication adherence is notoriously low among children due to difficulty swallowing pills and rejection of bad tasting medicationsAlthough some common pediatric drugs have flavored liquid formsp ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. ClearScope

    SBC: MICROBRIGHTFIELD, INC.            Topic: 101

    Combined in vivo and ex vivo three dimensionalDwhole brain imaging of non transgenic and transgenic animal models holds the promise of novel insights into neural network connectivity patternsWith regard to ex vivo light microscopic imaging ofD whole brain datasetsthe best approach is brain clearing followed by whole brain light sheet microscopyLSMbecause of its unique combination of speedD resolvi ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. Caring for the Caregiver: A Theory-Driven Mobile Intervention to Promote Caregiver Well-Being

    SBC: Pro-Change Behavior Systems Inc            Topic: NIA

    Overmillion Americans are currently providing unpaid care to a family memberrelativeor friend with Alzheimer s disease or related dementiaWhile caregiving can be a positive experience that brings meaning and an increased sense of purposeit can also take a tollNearlyof Alzheimer s and dementia caregivers rate their emotional distress as high or very highand as many assuffer from depressionCaregiver ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. Rapid Test to Assist Therapy in Neonatal Sepsis and Necrotizing Enterocolitis

    SBC: PROTHERA BIOLOGICS, LLC            Topic: R

    The primary goal of this proposed research is to develop a rapid point of care test that assesses the risk of neonatal sepsisNSand or necrotizing enterocolitisNECin infants based on Inter alpha inhibitor proteinsIAIPlevels in bloodThe test is expected to be simpleuser friendlyportable and suitable for use in the NICUNS and NEC are associated with high mortality and morbidityincluding adverse neuro ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. Development of an Enhanced, Simplified Blood Coagulation Test to Monitor Patients on Direct Oral Anti-Coagulants

    SBC: Haematologic Technologies, Inc.            Topic: NHLBI

    Project SummaryOver the lastyearsDirect Oral AnticoagulantsDOACshave become increasingly prevalent for treating patients with cardiovascular disorders because of their pharmacokinetic stability and lack of interaction with certain foodsYetthere is increasing evidence of improper dosing in a small proportion of treated patientsand growing recognition of the need to develop simpleinexpensive tests t ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. SnapCap: a device to decontaminate central venous catheters (CVC) with 5 snaps

    SBC: Contech Medical, Inc.            Topic: NICHD

    Project Summary Abstract We propose a new approach to the decontamination of central venous catheters and the prevention of central line associated bloodstream infectionsCLABSIan important healthcare associated infectionCLABSIs cost the US healthcare system approximately $billion annuallyPronovostNEJMAdditionallyCLABSIs can be life threateningespecially in the very young and critically illEven whe ...

    STTR Phase I 2018 Department of Health and Human Services
  8. Neuroinformatics platform using machine learning and content-based image retrieval for neuroscience image data

    SBC: MICROBRIGHTFIELD, INC.            Topic: 101

    This project aims to develop NeuroManageran innovative neuroinformatics platform for advanced parsingstoringaggregatinganalyzing and sharing of complex neuroscience image dataA core technology that we will develop in NeuroManager will be Image Content Analysis for Retrieval Using SemanticsICARUSa novelintelligent neuroimage curation system that will enable image retrieval based on visual appearanc ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. Galectin-1 Protein Therapy for Congenital Muscular Dystrophy


    Abstract Lamininrelated congenital muscular dystrophyLAMACMDalso known as Merosin Deficient Congenital Muscular DystrophyMDC Ais a fatal muscle wasting disease that affects patients from birthLAMACMD results from mutations in the LAMAgene resulting in loss of lamininproteinLamininis required for the formation of the heterotrimers lamininand lamininwhich are major constituents of the skeletal and c ...

    STTR Phase I 2018 Department of Health and Human Services
  10. Novel Arm Restraint For Critically Ill Patients To Reduce Immobility, Sedation, Agitation and Cognitive Impairment

    SBC: Healthy Design Ltd. Co.            Topic: NIA

    ABSTRACT The goal of this Fast Track STTR project is to optimize and test a novel arm restraint in older critically ill mechanically ventilated patients that increases mobilityreduces agitationuse of sedative medicationsand deliriumand exhibits high satisfaction and acceptability among hospital stafffamily membersand patientsOlder mechanically ventilated patients are often immobilized with wrist r ...

    STTR Phase I 2018 Department of Health and Human Services

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