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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Implantable Noise-Based Sensory Enhancement Devices

    SBC: AFFERENT CORPORATION            Topic: N/A

    Stochastic resonance (SR) is a counterintuitive phenomenon in which slight amounts of noise imparted to a system actually increase its sensitivity to weak stimuli. SR has been shown to produce a demonstrable effect in human sensory cells. In both healthy young and clinical subjects - elderly, diabetics, and stroke sufferers - a notable increase in tactile and proprioceptive sensitivity is seen whe ...

    SBIR Phase I 2001 Department of Health and Human Services
  2. ENHANCING THE TACTILE SENSE USING MECHANICAL NOISE

    SBC: AFFERENT CORPORATION            Topic: N/A

    Stochastic resonance (SR), a counterintuitive phenomenon in which slight amounts of environmental noise actually increase the discernability of signals or stimuli, produces a demonstrable effect in human sensory cells. In both healthy young and clinical subjects- elderly, diabetics, and stroke sufferers-a significant increase in tactile and proprioceptive sensitivity is noted when electrical or me ...

    SBIR Phase I 2001 Department of Health and Human Services
  3. Restoring Diabetic Tactile Sense with Mechanical Noise

    SBC: AFFERENT CORPORATION            Topic: N/A

    Stochastic resonance (SR) is a counterintuitive phenomenon in which slight amounts of noise imparted to a system actually increase its sensitivity to weak stimuli. SR has been shown to produce a demonstrable effect in human sensory cells. In both healthy young and clinical subjects-elderly, diabetics, and stroke sufferers-a notable increase in tactile and proprioceptive sensitivity is seen when el ...

    SBIR Phase I 2001 Department of Health and Human Services
  4. Novel Two-Dimensional LIF Detector for DNA Sequencing

    SBC: DAKOTA TECHNOLOGIES, INC.            Topic: N/A

    DESCRIPTION (Applicant's abstract): This Phase I SBIR project introduces a novel laser-induced fluorescence (LIF) detector that will raise DNA sequencing to a new level. All commercial sequencers make basecalls from one-dimensional fluorescence data, viz., intensities at four wavelengths. Fluorescence lifetime, another basecalling option, is developmental. Our ...

    SBIR Phase I 2001 Department of Health and Human Services
  5. Epitope driven HPV Vaccine Targeting Dentritic Cells

    SBC: EPIVAX, INC.            Topic: N/A

    Human Papilloma Virus (HPV) types 16 and 18 are detected in roughly 70% of all invasive cervical tumors. Among cytologically normal women, detection of HPV infection by PCR has been shown to increase the subsequent risk of cervical cytologic abnormalities by 12 fold, suggesting that effective vaccines (preventive/therapeutic) for HPV infection would be a useful medical advance in the battle agains ...

    SBIR Phase I 2001 Department of Health and Human Services
  6. Diagnostic Reagents for Emerging Infectious Diseases

    SBC: EPIVAX, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): West Nile virus (WNV) is a flavivirus commonly found in Africa, West Asia, and the Middle East. The virus was introduced into the United States in 1999. Case-fatality rates during the 1999-2000 U.S. epidemics ranged from 3 percent to 15 percent and were highest in the elderly. The virus is expected to over-winter during ...

    SBIR Phase I 2001 Department of Health and Human Services
  7. ENHANCED DNA MICROARRAY PERFORMANCE WITH GAPPED PROBES

    SBC: GENESPECTRUM            Topic: N/A

    The goal of this project is to develop a more powerful and robust system for the sequencing and analysis of DNA by hybridization to microarrays. Our conceptually novel approach is based on a new probe design and sequence reconstruction algorithm which has been demonstrated by computational modeling to provide higher information density on a DNA hybridization chip. The Human Genome Project is provi ...

    SBIR Phase I 2001 Department of Health and Human Services
  8. EYE-COM 6/MSV CAMERA: A Drowsiness Detecting Biosensor

    SBC: NDC AND WSDC WASHOE SLEEP DISORDERS CENTER            Topic: N/A

    N/A

    SBIR Phase I 2001 Department of Health and Human Services
  9. Choroidal Neovascular Occlusion Using PDT

    SBC: LAMBDA PHARMACEUTICALS            Topic: N/A

    DESCRIPTION (From the Applicant's Abstract): Photodynamic therapy (PDT) is a new potential treatment of the subfoveal choroidal neovascularization (CNV) that may accompany age-related macular degeneration (AMD). PDT involves the use of a photosensitizing agent which, when activated by light, may selectively kill proliferating ...

    SBIR Phase I 2001 Department of Health and Human Services
  10. An Expert System to Reduce Depression in Primary Care

    SBC: Pro-Change Behavior Systems Inc            Topic: N/A

    A variety of effective interventions exist for people who seek help for depression. However, there is a lack of effective interventions for individuals who do not seek help or follow through with treatment referrals. We propose to fill this gap in services by developing and testing a Transtheoretical Model-based intervention that will be delivered proactively, on a population basis, to primary car ...

    SBIR Phase I 2001 Department of Health and Human Services

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