Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Macromolecule Crystallization Screening Results Analysis

    SBC: IXPRESSGENES, INC.            Topic: 100

    DESCRIPTION provided by applicant Crystallization followed by subsequent structure determination is a major step in understanding the structure function relationship of macromolecules Understanding macromolecule structure has become a key part in the development of new pharmaceuticals and is a major area of NIH research Crystallization however is also the rate limiting step despite techno ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  2. Development of a Novel Membrane Protein Solubilization/Stabilization Screen

    SBC: SOLUBLE THERAPEUTICS, INC            Topic: 100

    DESCRIPTION provided by applicant The increasing output of new integral membrane protein IMP structures is partially due to the availability of an increasing number of chemical variables such as detergents detergent like molecules lipids and solubilizing stabilizing additives It is clear that specific combinations and concentrations of these different variables are often necessary to impr ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. Optimization of an integrin enhancing molecule for the treatment of Duchenne muscular dystrophy

    SBC: STRYKAGEN CORPORATION            Topic: NIAMS

    DESCRIPTION provided by applicant Duchenne muscular dystrophy is caused by mutations in the dystrophin gene resulting in the loss of the dystrophin glycoprotein complex in skeletal muscle Loss of dystrophin results in reduced sarcolemmal integrity progressive muscle damage and compromised muscle function There is currently no cure and limited treatment options for DMD and all affected child ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  4. Measurement and Modeling of Surface Coking in Fuel-Film Cooled Liquid Rocket Engines

    SBC: CFD Research Corporation            Topic: AF15AT21

    ABSTRACT: Designing an efficient and effective film cooling system to protect critical components of modern rocket engines requires a significant number of challenges to be addressed. Complicating the already difficult hydrodynamic challenges, thermal cracking of hydrocarbon fuels is always accompanied by coke formation. The coke deposits on the combustor and nozzle walls reduces heat fluxes and c ...

    STTR Phase I 2015 Department of DefenseAir Force
  5. Prediction and Measurement of the Carbon Build-Up in Film-Cooled Rocket Engines

    SBC: SIERRA ENGINEERING, INC.            Topic: AF15AT21

    ABSTRACT: Sierra Engineering Inc. (Sierra) believes that existing chemical kinetic models can be efficiently incorporated into commercial CFD codes to predict the mixing, pyrolysis, soot formation and carbon deposition within film cooled rocket engines. During this Phase I STTR effort we will demonstrate that this analysis capability is practical and that we can generate appropriate model validati ...

    STTR Phase I 2015 Department of DefenseAir Force
  6. High Speed Electronic Device Simulator

    SBC: CFD Research Corporation            Topic: AF15AT33

    ABSTRACT: This project will develop and demonstrate a software package based on coupled Fokker-Planck (FP) - Fermi Kinetic Transport (FKT) models and full-wave Maxwell electromagnetic (EM) solver to accurately predict semiconductor device behavior from dc up through the mm-wave and THz frequency ranges. The FP model provides accurate non-equilibrium occupation functions for hot electrons with real ...

    STTR Phase I 2015 Department of DefenseAir Force
  7. Impact of Hypersonic Flight Environment on Electro-Optic/Infrared (EO/IR) Sensors

    SBC: Analysis and Applications Associates, Inc.            Topic: AF15AT40

    ABSTRACT: Analysis and Applications and Associates, Inc. (AAA) proposes to develop software that evaluates effects of the hypersonic flow environment on electro-optic/infrared optical systems and vehicles for specific hypersonic flight profiles. We propose a high fidelity definition of the near-field flow, using the latest CFD and turbulence modeling technologies, to determine the environment from ...

    STTR Phase I 2015 Department of DefenseAir Force
  8. Minimal piggyBac vectors for chromatin integration

    SBC: EXSCIEN CORPORATION            Topic: NIGMS

    In this grant, we describe novel transposon piggyBac vectors engineered to deliver transgenes as efficiently as currently available piggyBac systems, but with significantly less helper DNA co-delivered into the host genome. To generate these plasmids, we first identified an important and previously unreported aspect of transposon biology, that the full-length terminal domains required for successf ...

    STTR Phase I 2014 Department of Health and Human Services
  9. Enhancing mtDNA Repair During Stroke Reperfusion to Reduce Brain Damage

    SBC: EXSCIEN CORPORATION            Topic: NINDS

    DESCRIPTION (provided by applicant): Attempts to develop drug treatments for acute stroke have not fulfilled expectations. Perhaps best illustrating this unsatisfactory situation is the hisory of therapeutic strategies directed at the inhibition of reactive oxygen species (ROS). While decades of laboratory and clinical studies make it clear that ROS are pathogenically important across the entire s ...

    STTR Phase I 2014 Department of Health and Human Services
  10. New Functionally-Graded Biohybrid Vascular Graft

    SBC: Vivo Biosciences Inc            Topic: NCATS

    DESCRIPTION (provided by applicant): In this Phase I STTR proposal, our RandD goal is the development and evaluation of a novel functionally-graded biohybrid vascular graft for small diameter (lt6 mm) coronary bypass applications. Tissue engineered vascular constructs developed to date have mostly utilized synthetic and animal- derived biomaterials and require pre-seeding of host cells before impl ...

    STTR Phase I 2014 Department of Health and Human Services
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