Award Data

For best search results, use the search terms first and then apply the filters
Reset

The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Engineering a phosphotyrosyl-tRNA Synthetase

    SBC: AXIOMX INC            Topic: 300

    DESCRIPTION provided by applicant Although tyrosine phosphorylation is an important controlling element in cell signaling no tRNA suppressor for phosphotyrosine pTyr incorporation has yet been made We propose to use directed molecular evolution of several aminoacyl tRNA synthetases aaRSs to identify mutations that enable binding of pTyr to the aaRS Specifically ATP molecules will be att ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  2. Measuring toxicant effects on cellular function in a microarray format

    SBC: CIENCIA INC            Topic: NIEHS

    DESCRIPTION provided by applicant The EPA maintains a Toxics Release Inventory of over toxic chemicals that are disposed or released from more than industrial sites in the United States The Department of Health and Human Services and USDA maintain a list of over select agents and toxins that pose a severe risk to both human animal and plant health These compounds represent only ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. Optimization of an integrin enhancing molecule for the treatment of Duchenne muscular dystrophy

    SBC: STRYKAGEN CORPORATION            Topic: NIAMS

    DESCRIPTION provided by applicant Duchenne muscular dystrophy is caused by mutations in the dystrophin gene resulting in the loss of the dystrophin glycoprotein complex in skeletal muscle Loss of dystrophin results in reduced sarcolemmal integrity progressive muscle damage and compromised muscle function There is currently no cure and limited treatment options for DMD and all affected child ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  4. Prediction and Measurement of the Carbon Build-Up in Film-Cooled Rocket Engines

    SBC: SIERRA ENGINEERING, INC.            Topic: AF15AT21

    ABSTRACT: Sierra Engineering Inc. (Sierra) believes that existing chemical kinetic models can be efficiently incorporated into commercial CFD codes to predict the mixing, pyrolysis, soot formation and carbon deposition within film cooled rocket engines. During this Phase I STTR effort we will demonstrate that this analysis capability is practical and that we can generate appropriate model validati ...

    STTR Phase I 2015 Department of DefenseAir Force
  5. Secure Efficient Cross-domain Protocols

    SBC: SONALYSTS, INC.            Topic: AF13AT08

    ABSTRACT: The Sonalysts Team proposes to develop a solution to establish secure cross enclave network interfaces that facilitate the flow of data between different levels of classification while improving and ensuring both security and data integrity. We will develop a prototype software application that will complement Cross-Domain Solution (CDS) installations by standardizing configuration and ...

    STTR Phase II 2015 Department of DefenseAir Force
  6. Additive Manufacturing Plastic Materials with Improved Dielectric Breakdown Strength

    SBC: Printed Performance Innovations            Topic: AF15AT07

    ABSTRACT: Material extrusion 3D printing is an Additive Manufacturing method which utilizes a polymeric monofilanment as a feedstock in the fabrication of 3D objects. The relative simplicity compared to other AM technologies makes it an attractive manufacturing tool, however, characteristics inherent to this 3D printing method (namely air gaps between print rasters) makes it undesirable for the 3D ...

    STTR Phase I 2015 Department of DefenseAir Force
  7. Removal of Amyloid-beta Peptides from the Alzheimer's Brain

    SBC: WE BIOSCIENCES, LLC            Topic: NIA

    DESCRIPTION (provided by applicant): As the Alzheimer's disease (AD) population is growing rapidly, currently there are no cure treatments. The goal of this resubmitted STTR proposal is to conduct a preclinical study with pramlintide to prove a potential treatment for AD. We have revised the proposal significantly according to the reviewers' comments. Pramlintide is an FDA approved drug ...

    STTR Phase I 2014 Department of Health and Human Services
  8. Functional-selection of affinity reagents against DNA-protein complexes using targeted chromatin sequences

    SBC: AXIOMX INC            Topic: NIDDK

    DESCRIPTION (provided by applicant): Site-specific binding of proteins to DNA plays an important role in cell development, cell signaling, the cell cycle, and diseases such as cancer. There are two overarching goals to this proposal: (1) to develop a meansfor the identification of proteins bound to specific DNA sequences, and (2) to develop a better method for the identification of immunoprecipita ...

    STTR Phase I 2014 Department of Health and Human Services
  9. Flexible Ion-Mediated Artificial Retina

    SBC: LAMBDAVISION, INC.            Topic: NEI

    DESCRIPTION (provided by applicant): A flexible, protein-based, ion-mediated retinal implant is proposed for the restoration of vision for patients with retinal degenerative diseases, such as age-related macular degeneration (AMD) and retinitis pigmentosa(RP). The implant under development uses the retinal- containing protein, bacteriorhodopsin (BR), to convert light into a pH gradient. This gradi ...

    STTR Phase I 2014 Department of Health and Human Services
  10. Measurement of Beta Cell Death in Diabetes

    SBC: L2 DIAGNOSTICS, LLC            Topic: 200

    DESCRIPTION provided by applicant All forms of diabetes are characterized by the death of insulin producing cells In Type diabetes T D this leads to the reliance on exogenous insulin for survival Death of cells is silent it cannot be detected in vivo until it has progressed to such an extent that metabolic function is impaired The loss of cells has only been assessed by functiona ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
US Flag An Official Website of the United States Government