Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. HLS13-13 Albumin nanoparticle based technology to treat ARDS

    SBC: CELL BIOLOGICS INC            Topic: NHLBI

    DESCRIPTION provided by applicant Severe infections various types of trauma and other etiologic factors can cause ALI that rapidly morphs into ARDS The incidence of ALI ARDS is around in adults in US alone Despite medical advances and better management through ventilation intervention the mortality is still unacceptably high at This problem is likely to escalate given the a ...

    STTR Phase I 2015 Department of Health and Human Services
  2. Mapping electrogram morphology recurrence for atrial fibrillation ablation

    SBC: Gold T-Tech, Inc            Topic: NHLBI

    DESCRIPTION provided by applicant Atrial fibrillation AF is the most common diagnosed arrhythmia with the number Americans diagnosed with AF estimated at million and continuing to increase as the population ages Electrical activity during AF is characterized by complex activation patterns that are difficult to map However there is growing evidence that AF is driven by stable sources i ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. Optimization of an integrin enhancing molecule for the treatment of Duchenne muscular dystrophy

    SBC: STRYKAGEN CORPORATION            Topic: NIAMS

    DESCRIPTION provided by applicant Duchenne muscular dystrophy is caused by mutations in the dystrophin gene resulting in the loss of the dystrophin glycoprotein complex in skeletal muscle Loss of dystrophin results in reduced sarcolemmal integrity progressive muscle damage and compromised muscle function There is currently no cure and limited treatment options for DMD and all affected child ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  4. Nonequilibrium Plasma-Assisted Combustion-Efficiency Control in Vitiated Air

    SBC: CU AEROSPACE L.L.C.            Topic: AF13AT04

    ABSTRACT: CU Aerospace (CUA) and team partner the University of Illinois at Urbana-Champaign (UIUC) propose to perform research, development and demonstration of experimental quenching free measurements of heat-release in a realistic highly turbulent plasma-assisted flame. Kinetics models will be correspondingly updated and detailed 3D multiphysics simulations will be validated by the measurements ...

    STTR Phase II 2015 Department of DefenseAir Force
  5. Prediction and Measurement of the Carbon Build-Up in Film-Cooled Rocket Engines

    SBC: SIERRA ENGINEERING, INC.            Topic: AF15AT21

    ABSTRACT: Sierra Engineering Inc. (Sierra) believes that existing chemical kinetic models can be efficiently incorporated into commercial CFD codes to predict the mixing, pyrolysis, soot formation and carbon deposition within film cooled rocket engines. During this Phase I STTR effort we will demonstrate that this analysis capability is practical and that we can generate appropriate model validati ...

    STTR Phase I 2015 Department of DefenseAir Force
  6. Microvascular Composites for Novel Thermal Management Devices

    SBC: CU AEROSPACE L.L.C.            Topic: AF13AT09

    Living systems rely on pervasive vascular networks to enable a plurality of biological function, exemplified by natural composite structures that are lightweight, high-strength, and capable of mass and energy transport. In contrast, synthetic composites possess high strength-to-weight ratios but lack the dynamic functionality of their natural counterparts. CU Aerospace, with team partners the Univ ...

    STTR Phase II 2015 Department of DefenseAir Force
  7. Quantum and Nanostructure Enhanced Epitaxial Lift-Off Solar Cells

    SBC: MicroLink Devices            Topic: AF13AT13

    The Air Force, will benefit from the radiation-hard, lightweight, flexible, high-efficiency solar cells, which will enable greater capability on future spacecraft. Spacecraft will have a longer lifetime in high radiation orbits; alternatively, less radiation shielding, and hence less weight, will be required to provide the same endurance available at present. In the longer term, lightweight, flexi ...

    STTR Phase II 2015 Department of DefenseAir Force
  8. Topically-delivered Targeted Gene Suppression of Immune Activation in Psoriasis

    SBC: Exicure, Inc.            Topic: NIAMS

    DESCRIPTION (provided by applicant): AuraSense Therapeutics (AST), along with Northwestern University, is applying a recently developed technology using oligonucleotide-functionalized nanoparticles (called spherical nucleic acids or SNAs) to control protein expression. These easily synthesized nanoparticles can have either DNA or RNA shells, and are less than 50 nm in hydrodynamic diameter. SNA co ...

    STTR Phase I 2014 Department of Health and Human Services
  9. Engineering Cytolytic Effectors to Eliminate Virus-Infected and Cancer Cells

    SBC: IMMUVEN, INC.            Topic: NCI

    Project Summary The goal of this STTR grant application is to engineer powerful NK cell-based cytolytic effector cells for therapeutic applications. The cells will combine the selectivity and specificity of T cells and the ability of NK cells to mediate effective cytolytic activity against a wide spectrum of aberrant cells, including those with impaired adhesion properties. To achieve this goal we ...

    STTR Phase I 2014 Department of Health and Human Services
  10. Developing Therapeutics That Target RAD51 to Treat Leukemia and Lymphoma

    SBC: Cyteir Therapeutics, Inc.            Topic: NCI

    DESCRIPTION (provided by applicant): Genomic instability is a hallmark of cancer, yet is underdeveloped as a therapeutic target area The central goal of this program is to develop new cancer therapeutics that target genomic instability as a hallmark of cancer cells, bringing new, cancer-cell selective treatments to the clinical oncology market. Two key challenges in current cancer therapy are mini ...

    STTR Phase I 2014 Department of Health and Human Services
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