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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Rapid Magnetomotive Thrombolysis for Stroke

    SBC: Pulse Therapeutics, Inc.            Topic: 105

    DESCRIPTION provided by applicant Acute ischemic stroke AIS is the result of a blood clot in a cerebral artery It remains a leading killer and the leading cause of long term disabilit annually impacting over Americans Because brain tissue rapidly dies time to reperfusion is critical in both preventing death and improving neurological outcomes While current annual costs relat ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  2. Modular, Low Cost Fixture for Evaluating OML Treatments for Stress-Strain Loading During Environmental Conditioning

    SBC: Material and Process Solutions, LLC            Topic: AF141167

    ABSTRACT:Material and Process Solutions LLC will build a modular, outer mold line (OML) gap fatigue test fixture that can be used to predict the overall lifetime of a complete OML stack-ups (gap filler and coatings) used on aircraft.We will evaluate two complete OML stack-ups at three conditions: no exposure, and both sequential and concurrent environmental conditioning and fatigue testing.The mod ...

    SBIR Phase II 2015 Department of DefenseAir Force
  3. Efficient shaping or reshaping of complex 3D parts using engineered residual stress

    SBC: Engineering Software Research And Development, Inc.            Topic: AF141170

    ABSTRACT:Increasing emphasis on affordability of military systems has led to a number of advances in airframe production. For example, high speed machining (HSM) has made it possible to fabricate thin structures that provide improved performance. However, near-surface plastic strains induced by HSM or surface treatments can lead to excessive component distortion such that the component requires re ...

    SBIR Phase II 2015 Department of DefenseAir Force
  4. Rational design of small interfering RNA for genome-wide target knockdown

    SBC: Nawgen, LLC            Topic: 172

    DESCRIPTION provided by applicant RNA interference RNAi is a small RNA guided gene silencing process within living cells The RNAi technique is widely used in both biological research and clinical applications because it has the ability to knockdown essentially any gene of interest However one major unresolved issue in RNAi studies is non specific gene silencing It is well known that in ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  5. Development of a prototype system for assaying exocytosis from individual cells using using transparent microelectrode arrays

    SBC: EXOCYTRONICS, LLC            Topic: 101

    DESCRIPTION provided by applicant Cells secrete hormones and neurotransmitter via exocytosis Understanding how exocytosis is regulated and how pharmaceuticals and toxins inhibit exocytosis is of broad medical significance because it aids in developing approaches to treat medical conditions where release of transmitter needs to be enhanced e g Parkinsonandapos s disease or inhibited e g ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  6. Optimized IL2-based Therapy for Type 1 Diabetes

    SBC: APT THERAPEUTICS, INC.            Topic: NIDDK

    DESCRIPTION provided by applicant Type diabetes is an immune mediated disease in which insulin producing beta cells are destroyed resulting in life long dependence on exogenous insulin The number of patients being diagnosed is increasing each year particularly in the very young Despite advances in glucose monitoring and insulin delivery there is a compelling need to identify therapies th ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  7. Therapeutic Role of Inter-alpha Inhibitors in Wound Healing

    SBC: PROTHERA BIOLOGICS, INC.            Topic: NIAMS

    DESCRIPTION provided by applicant Wound healing is an intricately regulated process broadly characterized by phases of inflammation proliferation and remodeling Imbalances in any one of these phases can result in inadequate healing scar formation or in the development of chronic wounds such as diabetic ulcers Diabetic ulcers are responsible for the majority of lower extremity amputations ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  8. Low-dose IL-2-based Immunomodulatory Therapy for PAH

    SBC: APT THERAPEUTICS, INC.            Topic: NHLBI

    DESCRIPTION provided by applicant Despite evidence that inflammatory mechanisms initiate and complicate pathophysiology in pulmonary arterial hypertension PAH no strategies have been developed to target the inflammatory cells involved Moreover it has been known for years that autoimmune diseases are associated with certain forms of PAH Hence novel therapy is urgently needed to attenuate ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  9. Recruiting underserved populations into clinical trials with customizable media

    SBC: Health Communication Impact, LLC            Topic: 100

    DESCRIPTION provided by applicant Racial and ethnic minorities older adults and those from rural communities continue to be underrepresented in cancer and other clinical trials research despite annual spending on patient recruitment in excess of $ billion While many individual studies have demonstrated that targeted outreach and education to underrepresented patients and engagement of fro ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  10. Tool to Assess State of Digital System after Electromagnetic Disruption

    SBC: Embedezyne LLC            Topic: AF151010

    ABSTRACT: Commercial off the shelf (COTS) electronic components have long been used by many companies in a wide range of industries to assist in their day to day operations. Most companies today use COTS computer workstations, servers, and networking devices in one form or fashion. While cost effective, COTS components are not required to adhere to strict Electromagnetic Compatibility (EMC) standa ...

    SBIR Phase I 2015 Department of DefenseAir Force
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