Award Data

ABSTRACT: MO-SCI Corporation and Missouri University of Science and Technology have developed and evaluated fusion welding technology applicable to ultra-high temperature ceramic (UHTC) composite joining during a Phase I ceramic joining program. This Phase II program will improve arc and reactive plasma arc welding techniques and consumables to improve joint quality. Work in the Phase I resulted ...

ABSTRACT: The objective of the Phase II effort is to extend the mathematical model investigated in the Phase I to include wind speed as well as temperature modeling, continue its development for a University of Notre Dame Wind Tunnel Facility, and demonstrate utility by adopting the model to a government facility specified by AFOSR. Specifically, the Phase II will include developmental work in ma ...

ABSTRACT: The proposal outlines work and time tables associated with finalizing the development of wear model concepts developed in Phase I work to predict the wear of two materials sliding with respect to each other while being subjected to high velocities and/or high pressures. In parallel with this, a severe wear bench test fixture design will be finalized, built, and utilized to validate the ...

DESCRIPTION (provided by applicant): Sudden cardiac death is a major cause of death around the world, with approximately 400,000 sudden deaths per year in the United States, more than are attributed to lung cancer, breast cancer, or AIDS. It is often caused by ventricular fibrillation (VF) and ventricular tachycardia (VT). VF is the most frequent mechanism of sudden death. Implantable cardiac defi ...

? DESCRIPTION (provided by applicant): Poor prognosis cancers such as lung cancer, glioblastoma, pancreatic cancer and others have 3 year survival rates that range from 1%-15%. Recent advancements in the development of therapeutic antibodies haveshown promise in other cancers such as breast, head and neck, and colon cancer. The limitations in antibody development are the paucity of cancer ...

DESCRIPTION provided by applicant Duchenne Muscular Dystrophy DMD is a fatal muscle disease affecting in every male births DMD results from mutations in the gene encoding the dystrophin a kDa scaffolding protein responsible for providing a mechanical link between the muscle fiber actin cytoskeleton and a transmembrane protein complex called the dystrophin associated glycoprotein ...

DESCRIPTION provided by applicant The number of Lyme disease cases in the US has been recently estimated by the CDC at cases year This is major public health concern Currently available diagnostics rely on detection of the antibody response serology to Borrelia burgdorferi the causative agent of Lyme disease However serological tests are not accurate during the early stages of Ly ...

ABSTRACT: Sierra Engineering Inc. (Sierra) believes that existing chemical kinetic models can be efficiently incorporated into commercial CFD codes to predict the mixing, pyrolysis, soot formation and carbon deposition within film cooled rocket engines. During this Phase I STTR effort we will demonstrate that this analysis capability is practical and that we can generate appropriate model validati ...

DESCRIPTION provided by applicant MicroRNAs miRNAs are involved in many diverse biological processes and a single miRNA can modulate the expression of hundreds of gene targets Changes in miRNA expression could have profound biological impacts leading to a variety of human diseases To date most miRNA expression profiling studies have relied on microarrays or high throughput RNA sequencing ...

DESCRIPTION provided by applicant RNA interference RNAi is a small RNA guided gene silencing process within living cells The RNAi technique is widely used in both biological research and clinical applications because it has the ability to knockdown essentially any gene of interest However one major unresolved issue in RNAi studies is non specific gene silencing It is well known that in ...