Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Novel mass spectrometry methods for profiling modified RNA nucleotides in the nervous system

    SBC: Ribonova Inc.            Topic: NIDA

    DESCRIPTION provided by applicant Pseudouridine is the most abundant post transcriptionally modified nucleoside found in ribonucleic acid RNA Pseudouridine is an enzymatically generated isomer of the canonical base uridine with additional hydrogen bonding capabilities and appears to lead to local structural and biochemical effects within RNAs Pseudouridine has been detected in several type ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  2. Polaris Oncology Survivor Transition POST System

    SBC: POLARIS HEALTH DIRECTIONS, INC            Topic: 100

    DESCRIPTION provided by applicant By January oncology care providers will be expected to craft Survivorship Care Plans SCPs for all individuals ending active treatment for cancer however there is a lack of systematic study of the impact survivorship planning has on patients providers or healthcare systems The Polaris Oncology Survivorship Transition POST program is a web based sy ...

    STTR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  3. mTOR Substrate Phosphorylation: A New Bioassay for Therapeutics

    SBC: COGNIZANCE BIOMARKERS, LLC            Topic: 107

    DESCRIPTION provided by applicant There are a growing number of human diseases that have been linked to abnormally enhanced activation of the mammalian target of rapamycin mTOR signaling cascade a central pathway governing eukaryotic protein synthesis These include neurodevelopmental disorders associated with epilepsy autism and intellectual disability as well as cancer obesity and dia ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  4. Neurotrophic Agents for Treating Parkinson's Disaese

    SBC: Seneb Biosciences, Inc.            Topic: 102

    DESCRIPTION provided by applicant Parkinsonandapos s disease PD is a neurodegenerative disorder characterized by motor function and eventually cognitive decline GM depletion is validated as a therapeutic target for Parkinsonandapos s disease PD in clinical studies in which GM replacement stabilized motor function loss and may be disease modifying However GM has poor pharmacologic prop ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  5. Optimization of an integrin enhancing molecule for the treatment of Duchenne muscular dystrophy

    SBC: STRYKAGEN CORPORATION            Topic: NIAMS

    DESCRIPTION provided by applicant Duchenne muscular dystrophy is caused by mutations in the dystrophin gene resulting in the loss of the dystrophin glycoprotein complex in skeletal muscle Loss of dystrophin results in reduced sarcolemmal integrity progressive muscle damage and compromised muscle function There is currently no cure and limited treatment options for DMD and all affected child ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  6. Novel sigma-2 receptor modulators for the treatment of cognitive dysfunction

    SBC: COGNITION THERAPEUTICS, INC.            Topic: NIA

    DESCRIPTION provided by applicant Cognition Therapeutics Inc andapos s mission is to develop effective therapeutics for Alzheimerandapos s disease AD Recent scientific discoveries have identified oligomers of the brain protein A as toxic culprits in disease progression Cognition in partnership with Temple University has identified a novel series of sigma receptor binding modulators t ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  7. DEVELOPMENT OF SMALL MOLECULE THERAPEUTICS AGAINST RNA VIRUSES

    SBC: Fox Chase Chemical Diversity Center, Inc.            Topic: R

    DESCRIPTION provided by applicant The ultimate goal of this project is to produce a broad spectrum drug for the treatment of viral infections caused by filoviruses Ebola and Marburg arenaviruses Lassa fever and rhabdoviruses rabies We and others have determined that efficient budding of these emerging human pathogens is dependent on the subversion of host proteins such as Nedd and t ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  8. Low-Latency Embedded Vision Processor (LLEVS)

    SBC: Sage Technologies, Ltd.            Topic: AF15AT13

    ABSTRACT: The proposed VPHS (Vision Processor for Helmet Systems) is an advanced technology image processing engine that is designed to provide the image processing requirements of helmet mounted imagery systems. The VPHS will input high resolution image data from imaging sensors, process that data to yield enhanced visualization and output the imagery to operator displays. The VPHS will employ im ...

    STTR Phase I 2015 Department of DefenseAir Force
  9. Brahms Contested Airspace Simulation Testbed (Brahms-CAST)

    SBC: Aqru Research and Technology, LLC            Topic: AF15AT14

    ABSTRACT: Remarkable advances in artificial intelligence (AI) and human-systems integration are providing aircrew with cockpit automation systems of unprecedented sophistication. Onboard intelligent assistants monitor the aircraft, interpret and carry out pilot commands, and advise the pilot (onboard or remote) as to aircraft and system status, mission progress, threats and alerts. Because pilots ...

    STTR Phase I 2015 Department of DefenseAir Force
  10. Prediction and Measurement of the Soot Build-Up in Film-Cooled Rocket Engines

    SBC: COMBUSTION RESEARCH AND FLOW TECHNOLOGY INC            Topic: AF15AT21

    ABSTRACT: Methodology for prediction of soot build-up in liquid film-cooled rocket engines will be incorporated into the CRUNCH CFD code, using a reduced-mechanism pyrolysis model and soot formation model developed at University of Virginia. A companion experimental program will be conducted at University of Virginia to collect data for calibration of the pyrolysis models for conditions and fuels ...

    STTR Phase I 2015 Department of DefenseAir Force
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