Award Data

DESCRIPTION provided by applicant Approximately Americans suffer from vision loss due to Retinitis Pigmentosa RP Despite significant progress in elucidating the molecular genetics of RP over the past three decades no disease modifying therapies have been approved There is compelling evidence implicating endoplasmic reticulum ER stress in the pathogenesis of various forms of RP e ...

DESCRIPTION provided by applicant The American Diabetes Association has declared type diabetes T D a public health crisis T D begins as a state of compensated insulin resistance frank disease develops when of insulin producing pancreatic islet cells of affected individuals undergo cell death Endoplasmic reticulum ER stress has emerged as a central underlying mechanism that drive ...

ABSTRACT: To complement capabilities of future autonomous systems, the Air Force requires interoperable tools & methodologies to design, verify, validate, assess & operate human-machine system interactions associated with autonomous and manned systems integration. Often the human performance measures and status of each simulation is reported independently making it challenging to analyze the data. ...

ABSTRACT: The objective of the proposed research effort is to demonstrate the feasibility of 100 kHz to 1 MHz nonlinear spectroscopy for measurements of molecular energy distributions, energy transfer, major species, and temperature in transient combusting and nonequilibrium flows. This will be accomplished, in part, by extending burst-mode laser technology to the fs and ps regimes for greater tha ...

ABSTRACT: Sierra Engineering Inc. (Sierra) believes that existing chemical kinetic models can be efficiently incorporated into commercial CFD codes to predict the mixing, pyrolysis, soot formation and carbon deposition within film cooled rocket engines. During this Phase I STTR effort we will demonstrate that this analysis capability is practical and that we can generate appropriate model validati ...

ABSTRACT: Scramjet engines are expected to operate across wide Mach number ranges and typically incorporate isolators to provide sufficient back-pressure margin and prevent unstart. Unfortunately, isolators introduce additional weight and drag, and form multiple shockwave/boundary layer interactions, which degrade the incoming flow. As military requirements become increasingly demanding, an active ...

ABSTRACT: The objective of the STTR Phase-I effort proposed by Spectral Energies LLC and The University of Tennessee is to demonstrate the feasibility of an in situ quantitative measurement of the products generated by the degradation of a material surface exposed to a hypersonic environment. The concept is based on a state-of-the-art diagnostic method: Coherent Microwave Rayleigh Scattering from ...

ABSTRACT: The goal of this proposal is to demonstrate the feasibility of a novel environmentally-compliant process to produce an advanced alloy coating(s) that imparts excellent corrosion and wear resistance to structural metals on military aircraft and weapon systems. The resulting composite coating and the coating process do not consist of any hazardous materials such as heavy metals chromium (C ...

DESCRIPTION provided by applicant Duchenne muscular dystrophy is caused by mutations in the dystrophin gene resulting in the loss of the dystrophin glycoprotein complex in skeletal muscle Loss of dystrophin results in reduced sarcolemmal integrity progressive muscle damage and compromised muscle function There is currently no cure and limited treatment options for DMD and all affected child ...

ABSTRACT: Temperature and magnetic field dependent terahertz spectroscopies have proven useful for characterizing novel electronic and magnetic materials. To this end, we are developing a turn-key, continuous-wave (CW) terahertz transmission platform operating from 5 K to 300 K with fields up to 9 T. Fiber-coupled photoconductive switches operate from 200 GHz to 1.2 THz in the cryogenic and high-f ...