Award Data

ABSTRACT: Sierra Engineering Inc. (Sierra) believes that existing chemical kinetic models can be efficiently incorporated into commercial CFD codes to predict the mixing, pyrolysis, soot formation and carbon deposition within film cooled rocket engines. During this Phase I STTR effort we will demonstrate that this analysis capability is practical and that we can generate appropriate model validati ...

The broader impact/commercial potential of this Small Business Innovation Research Phase I project will be to recycle materials for use in manufacture of advanced batteries. Success and commercialization of this projects? technology will facilitate recycling of consumer and electric vehicle waste batteries. The project enhances scientific understanding by demonstrating the durability, robustness a ...

The broader impact/commercial potential of this Small Business Innovation Research Phase I project, if successful, will be to advance the development of a novel microbial fuel cell (MFC) system that generates energy from the wastewaters being treated and that could significantly benefit wastewater treatment for a range of key industries. If successfully developed, the company's new MFC technology ...

ABSTRACT: The kinds of capability advancements we anticipate include scalable support for multi-vehicle scenarios with concurrent executions, co-existence of adversarial and cooperative assets, timing and synchronization constraints, heterogeneous sets of specifications (e.g., prioritization over soft vs. hard constraints), and fault-tolerance. The tool development will focus on an open-source so ...

DESCRIPTION provided by applicant Atrial fibrillation AF is the most prevalent type of cardiac arrhythmia in the developed world affecting million people in the United States alone a number that is expected to double by because of population aging Current pharmacological options are ineffective which may be in part because these drugs fail to target key pathogenic mechanisms Recen ...

DESCRIPTION provided by applicant Each year million Americans go to health care providers because of vertigo dizziness or balance problems It is the second most common complaint heard in doctorandapos s offices and will occur in of the nationandapos s population at sometime in their lives From through of US adults aged years and older million Americans had ve ...

DESCRIPTION provided by applicant Methamphetamine MA dependence is associated with long term damage to regions of the brain that control cognitive and psychiatric function One third to one half of MA dependent adults experience persistent cognitive and other psychiatric disorders up to three years or longer into remission The neuropsychiatric impairments that persist following abstinence ar ...

DESCRIPTION provided by applicant Human brain development represents a highly vulnerable time to chemical exposures because immature cells are actively undergoing differentiation into more complex cell types e g neurons astrocytes oligodendroglia to form neural circuits A major reason for this vulnerability is that neuronal differentiation requires critical time dependent changes to the ...

DESCRIPTION provided by applicant Stroke is a leading cause of morbidity and mortality in the United States However less than of patients are eligible for the current approved interventions of tissue plasminogen activator or thrombectomy We seek to develop new therapeutics to reduce the extent of damage and functional impairment resulting from ischemic injury to the brain an area of signi ...

DESCRIPTION provided by applicant Duchenne muscular dystrophy is caused by mutations in the dystrophin gene resulting in the loss of the dystrophin glycoprotein complex in skeletal muscle Loss of dystrophin results in reduced sarcolemmal integrity progressive muscle damage and compromised muscle function There is currently no cure and limited treatment options for DMD and all affected child ...