Award Data

The increased use of sensing systems and large scale networked nodes with a variety of embedded sensors and imagery is creating a plethora of varied data that needs to be fused and interpreted for applications such as surveillance, reconnaissance, and air traffic controls. The need for persistent human analysis with high levels of proficiency is taxing human resources and cognitive abilities. In t ...

PROJECT SUMMARY The long term goal of this proposal is to developvalidate and market robustcost effective technologies for highly multiplexed imaging of cells in liquid and solid biopsies at sub cellular resolution as a means to diagnose diseaseidentify patients likely to benefit from specific anti cancer drugsand investigate mechanisms of action of cytoxictargeted and immuno oncology drugsThis wi ...

ABST RACT Patients with acute blood malignancies who undergo allogeneic hematopoietic stem cell transplantationHSCTare monitored for minimal residual diseaseMRDas predictive of relapseIncreasing mixed chimerismreemerging recipient cellscorrelates with reappearance of underlying disease by association with MRDGenetic and immunophenotypic heterogeneity of these malignancies often prevents establishi ...

ABSTRACT Vaccination represents the single most effective and cost effective medical intervention devised to datesaving lives and reducing morbidity and disability for billions of humansDespite the early success of the oral polio vaccinemost vaccines are delivered parenterallyand as such are associated with painnon compliancebiohazardous medical waste and strict requirements for expensive producti ...

Project Summary Abstract We propose a new approach to the decontamination of central venous catheters and the prevention of central line associated bloodstream infectionsCLABSIan important healthcare associated infectionCLABSIs cost the US healthcare system approximately $billion annuallyPronovostNEJMAdditionallyCLABSIs can be life threateningespecially in the very young and critically illEven whe ...

Abstract Lamininrelated congenital muscular dystrophyLAMACMDalso known as Merosin Deficient Congenital Muscular DystrophyMDC Ais a fatal muscle wasting disease that affects patients from birthLAMACMD results from mutations in the LAMAgene resulting in loss of lamininproteinLamininis required for the formation of the heterotrimers lamininand lamininwhich are major constituents of the skeletal and c ...

Abstract SensoriisInc is a company thatdevelops evidence based sensing solutions to support biological investigations and address health care problemsThe goal of this NIH STTR grant with University of WashingtonUWis to provide a flexible system to assess cardiac electrical activities in zebrafish modelssupporting heart disease studies and drug screeningUnlike humanszebrafish hearts can fully regen ...

Project Summary Abstract Alcohol abuse remains a significant cause of preventable morbidity and mortality in the USYet onlyof those with AUD receive treatmentOur groupand others have demonstrated that contingency managementCMis an effective approach for reducing alcohol use in problematic drinkersThis project seeks to demonstrate the capability of an end to end CM platform designed to reduce alcoh ...

ABSTRACT: To produce high dielectric strength insulator materials, our approach, called Optimized Additive Manufacturing for High Dielectric Strength (OAHDS), will optimize fused filament fabrication (FFF) 3D printing in order to fabricate high density parts. Currently, thermoplastics 3D printed via FFF have dielectric strengths one to three orders of magnitude lower than injection molded parts ma ...

ABSTRACT: Sierra Engineering Inc. (Sierra) believes that existing chemical kinetic models can be efficiently incorporated into commercial CFD codes to predict the mixing, pyrolysis, soot formation and carbon deposition within film cooled rocket engines. During this Phase I STTR effort we will demonstrate that this analysis capability is practical and that we can generate appropriate model validati ...