Award Data

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With growing regulatory concern over the release of waterborne industrial pollutants, the US Environmental Protection Agency has identified metal finishing as an industrial operation whose pollutant discharge poses a significant threat to public health and the environment. Currently, the US Department of Defense (DoD) weapon system operations rely on metal hydroxide precipitation to treat metal fi ...

In this effort, powered upper extremity (two arms and modular, unpowered, application-specific end effectors) of a wearable exoskeleton robot used to augment human performance while performing logistical tasks will be developed, tested and demonstrated. The new exoskeleton, referred to as XO-MAX(UE)-L exoskeleton, will be integrated with the Lower Extremity, XO-MAX(LE)-L exoskeleton, developed und ...

Project Summary Age-related Macular Degeneration (AMD) is the leading cause of blindness in US. It affects over 25% of the people by the age 80. An estimated 25 million people are afflicted with AMD worldwide. Neovascular or “wet” AMD, which affects 10%–15% of AMD patients, is a rapid form of the disease and progresses to blindness if left untreated. Histopathologically, the disease involves ...

PROJECT SUMMARY Resective neurosurgery is essential for treating a range of neurologic conditions such as epilepsy and brain tumorsFor some patientswhose lesion is close to cortical language areaspostoperative expressive or receptive language deficit is a major and feared postoperative complicationMuch effort is devoted to identifying the cortical language regionsand relating such localization to ...

ABSTRACTThe threat of radiological and nuclear accidents or attacks demands for effective radiation medical countermeasuresMCMable to mitigate and treat the effects of exposure to ionizing radiationsHematopoietic acute radiation syndromeHRASand cutaneous radiation syndromeCRSpose severelife threatening risks to exposed individualsCurrently no effective radio mitigatorto be administered after radia ...

Glycosaminoglycans (GAGs) are polysaccharides composed of a repeated disaccharide subunit and known to be important for the maintenance of structure and mechanical properties of the extracellular matrix. More recently, changes in the content, size, and composition of GAGs have been found to play biological roles in disease processes as well. For example, chondroitin sulfate (CS) is the most abunda ...

Natural products or their derivatives have accounted for most of our current drugsdemonstrating their unique status asprivilegedmolecules that are well adapted for therapeutic useHowevernatural products have previously been unsuitable for modernhigh throughputHTdrug discovery screening approachesand as suchwere long ago abandoned in drug discovery programs of large pharmaThe substitute has been hi ...

Mucormycosis is one of the deadliest of the invasive fungal infections. Mucormycosis occurs most often in patients with hematological malignancies undergoing chemotherapy, patients who have received hematopoietic stem cell transplants or patients with diabetes mellitus. Improved diagnosis is the most frequently noted unmet need for management of the mucormycosis patient. Delays in treatment increa ...

1 PROJECT SUMMARY2 This application for a Phase II SBIR award extends the successful completion of Phase I and represents a 3 collaboration between Clinitech, LLC and McLean Hospital/Harvard Medical School to continue the4 development of a wearable biosensor for detecting alcohol in the interstitial fluid of humans. Excessive use of5 alcohol accounts for much of the public health burden related to ...