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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Therapeutic Administration of Suppressor of Cytokine Signaling Mimetics to Ameliorate Type Diabetes

    SBC: ONEVAX, LLC            Topic: NIAID

    Type Diabetes T D results from a breakdown of self tolerance that is characterized by immune cell mediated destruction of the insulin producing cells in the pancreas Ultimately glucose metabolism is interrupted resulting in the development of life threatening complications such as heart disease and renal failure T D affects an estimated million Americans with more than new patie ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Probabilistic Modeling for Software Guided Radiotherapy Patient Plan QA

    SBC: SUN NUCLEAR CORP.            Topic: 103

    Errors in the planning and delivery of radiation therapy can result in inferior outcomes for patients The magnitude of this problem is now well appreciated from cooperative group trials and other sources At present however there are few concrete tools to reduce the chance of plan errors passing undetected Current practice uses a variety of error mitigation means such as human inspection of th ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Identification of Small Molecule Amyloid Beta Peptide Reducing Agent

    SBC: Smart Biomolecules, Inc.            Topic: NIA

    Alzheimer s disease AD is a multifactorial heterogeneous and enormously complex disorder characterized by progressive intellectual deterioration Although remarkable advances have been made in unraveling the biological basis of the disease in the last two decades that immense knowledge has not been translated in to successful therapy With the failure of secretase inhibitors at the clinical tr ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Biocatalytic production of precursors to lutein and zeaxanthin to address age related macular degeneration

    SBC: EscaZyme Biochemicals, LLC            Topic: N

    Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Developing a novel therapy for diabetic retinopathy

    SBC: Everglades Biopharma, LLC            Topic: W

    Project Summary Diabetic retinopathy DR is a leading cause of vision loss affecting about million people worldwide A major breakthrough in DR therapy is the recent approval of vascular endothelial growth factor VEGF inhibitors However anti VEGF therapy has limited efficacy with a number of side effects The critical barrier is how to identify other angiogenic targets for alternative or ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. A Randomized Blinded Placebo Controlled Clinical Trial to Evaluate Longeveron Mesenchymal Stem Cell LMSC Therapy for Treating The Metabolic Syndrome

    SBC: Longeveron LLC            Topic: NIA

    The metabolic syndrome MetS is a cluster of factors that increases the risks for cardiovascular disease type diabetes mellitus and mortality and currently affects andgt of US adults MetS is associated with endothelial dysfunction decreased circulating endothelial progenitor cells EPCs and a pro inflammatory state We have made the exciting discovery that therapy with allogeneic me ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Learner Engagement and Motivation to Learn Assessment and Monitoring System

    SBC: Design Interactive, Inc            Topic: AF17AT009

    Training can now delivered on a large scale through platforms, but must be engaging to be effectively utilized. Key to providing training that makes a difference in the field is an understanding of how to induce high levels or engagement during learning, and the ability to objectively assess engagement in real-time so that interventions can be tailored during training to optimize engagement and m ...

    STTR Phase I 2017 Department of DefenseAir Force
  8. Development lightmap rendering technology to advance infrared simulation capabilities for training applications

    SBC: Cornerstone Software Solutions, Inc            Topic: AF17AT012

    Recent technology advances have enabled the simulation community to achieve greater realism in virtual training environments. As new methods for synthetic image generation are developed, the lack of readily available supporting data to populate these specialized techniques limits their implementation. Currently the capability is not available to efficiently generate enhanced temporal energy maps ...

    STTR Phase I 2017 Department of DefenseAir Force
  9. Plasmonic Metamaterial Approach to Infrared Scene Projection

    SBC: Truventic LLC            Topic: AF17AT022

    Truventic proposes a novel MEMS-based plasmonic infrared scene projector to support hardware-in-the-loop testing of missile seekers, forward looking IR cameras (FLIR), counter measure simulation and tracking systems. The approach avoids known limitations of resistive arrays and provides high dynamic range, unprecedented high apparent temperature, high modulation rates, high pixel to pixel contrast ...

    STTR Phase I 2017 Department of DefenseAir Force
  10. Plasmonic Metamaterial Approach to Infrared Scene Projection

    SBC: Plasmonics Inc.            Topic: AF17AT022

    As both the response speed and sensitivity of thermal imagers have improved significantly over recent years, new IRSP systems are needed to provide greater dynamic range and faster response speeds. Addressing these issues, as well as producing a cost effective and modular IRSP system will be critical for providing quality scene projection for the next generation of infrared imagers. To address the ...

    STTR Phase I 2017 Department of DefenseAir Force

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