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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. DEVELOPMENT OF A NOVEL ANTIVIRAL TO TREAT AND PREVENT ACYCLOVIR RESISTANCE IN HUMAN OCULAR HERPES KERATITIS

    SBC: Fox Chase Chemical Diversity Center, Inc.            Topic: N

    ABSTRACT Infection of the eye by Herpes Simplex Virus HSV can result in Herpes Keratitis HK which is the leading cause of corneal blindness worldwide In the U S nearly individuals experience ocular herpes infections that are often recurrent and culminate in progressive corneal scarring and loss of vision The gold standard of care for HK is treatment with Acyclovir ACV that t ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Tools for site specific antibody immobilization for immunoassays

    SBC: AlphaThera            Topic: N

    Antibodies most commonly Immunoglobulin Gs IgGs are widely used in research and diagnostic assays due to their wide array of targets high specificity and proven efficacy In many of these immunoassays e g ELISAandapos s biosensors etc antibodies must be immobilized onto surfaces The sensitivity stability and longevity of antibodies used in this context are highly dependent on orien ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. eHealth Mobile Technology Connecting Young Adults to Routine Engagement eMCARE a theoretically and empirically driven mobile intervention to engage young adults in healthcare

    SBC: NuRelm Inc.            Topic: NICHD

    eMCARE EHealth Mobile Technology Connecting Young Adults to Routine Engagement Young adults YAs ages have a worse health profile than adolescents or adults in their late twenties and thirties Most YAs in the US experience no preparation for the transition from pediatric to adult care often seeking care only through emergency department ED visits The results can be seen across issues ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Inhibitors of Hydrogen Sulfide Metabolism as a Novel Treatment for Heart Failure

    SBC: Fox Chase Chemical Diversity Center, Inc.            Topic: NHLBI

    The goal of this Phase I STTR grant application is to capitalize on our recent discovery of novel sulfide quinone oxidoreductase SQOR inhibitors by the design and preparation of new analogs for the treatment of heart failure that enable us to understand SAR so as to improve potency and optimize ADME PK properties Heart failure is a highly lethal disease affecting more than million adults in t ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Preparation of site specific antibody drug conjugates by proximity based sortase ligation

    SBC: AlphaThera            Topic: 103

    There has been growing interest in the use of antibody drug conjugates ADCs for the treatment of cancer as mounting data suggests an increase in anti tumor effectiveness and reduced toxicity compared with the administration of unlabeled antibodies in combination with chemotherapy The two ADCs that are currently approved by the FDA brentuximab vedotin Adcetris and ado trastuzumab emtansin ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Effects of LGM on a Primate Model of Asthma

    SBC: Lignamed, LLC            Topic: NIAID

    PROJECT SUMMARY We previously demonstrated in mice that the major pathogenic features eosinophilic airway inflammation and airway hyperresponsiveness AHR were markedly enhanced in mice exposed to repeated social stress and these changes were associated with impaired glucocorticoid receptor GR expression and function In studies on non human primates rhesus macaques at the California Natio ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Development and Validation of SafeClose Mesh Augmentation System for Hernia Prevention

    SBC: Paradigm Surgical LLC            Topic: 300

    Incisional hernia IH can be prevented using prophylactic mesh placement PMP which involved placement of mesh to reinforce an abdominal fascia closure before herniation occurs at the index of surgery PMP reduced the absolute risk of IH with an acceptable complication profile Open abdominal surgery techniques remain commonplace and contribute to the estimated cases of IH performed in ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Biocatalytic production of precursors to lutein and zeaxanthin to address age related macular degeneration

    SBC: EscaZyme Biochemicals, LLC            Topic: N

    Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Biodegradable gold nanoparticles as contrast agents for CT

    SBC: PolyAurum LLC            Topic: NIBIB

    PROJECT SUMMARY Computed tomography is used in about million imaging studies per year in the USA Iodinated contrast agents are used in roughly half of these studies Computed tomography is particularly important for the diagnosis of coronary artery disease where it depends on the use of iodinated contrast agents to visualize the arteries However these agents have a number of shortcomings s ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Therapeutic Mabs for Chronic Kidney Disease

    SBC: OPSIDIO LLC            Topic: 400

    Abstract Opsidio LLC is commercializing a monoclonal antibody MAb that will prevent and treat chronic kidney disease CKD that can lead to end stage renal disease ESRD and dialysis or kidney transplantation At the present time there is no known therapy for CKD that can alter the progression to end stage kidney failure The CDC estimates that there are million adult patients with CKD in t ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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