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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. DEVELOPMENT OF A NOVEL ANTIVIRAL TO TREAT AND PREVENT ACYCLOVIR RESISTANCE IN HUMAN OCULAR HERPES KERATITIS

    SBC: FOX CHASE CHEMICAL DIVERSITY CENTER INC.            Topic: N

    ABSTRACT Infection of the eye by Herpes Simplex Virus HSV can result in Herpes Keratitis HK which is the leading cause of corneal blindness worldwide In the U S nearly individuals experience ocular herpes infections that are often recurrent and culminate in progressive corneal scarring and loss of vision The gold standard of care for HK is treatment with Acyclovir ACV that t ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Tools for site specific antibody immobilization for immunoassays

    SBC: ALPHATHERA            Topic: N

    Antibodies most commonly Immunoglobulin Gs IgGs are widely used in research and diagnostic assays due to their wide array of targets high specificity and proven efficacy In many of these immunoassays e g ELISAandapos s biosensors etc antibodies must be immobilized onto surfaces The sensitivity stability and longevity of antibodies used in this context are highly dependent on orien ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. eHealth Mobile Technology Connecting Young Adults to Routine Engagement eMCARE a theoretically and empirically driven mobile intervention to engage young adults in healthcare

    SBC: NURELM, INC.            Topic: NICHD

    eMCARE EHealth Mobile Technology Connecting Young Adults to Routine Engagement Young adults YAs ages have a worse health profile than adolescents or adults in their late twenties and thirties Most YAs in the US experience no preparation for the transition from pediatric to adult care often seeking care only through emergency department ED visits The results can be seen across issues ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Inhibitors of Hydrogen Sulfide Metabolism as a Novel Treatment for Heart Failure

    SBC: FOX CHASE CHEMICAL DIVERSITY CENTER INC.            Topic: NHLBI

    The goal of this Phase I STTR grant application is to capitalize on our recent discovery of novel sulfide quinone oxidoreductase SQOR inhibitors by the design and preparation of new analogs for the treatment of heart failure that enable us to understand SAR so as to improve potency and optimize ADME PK properties Heart failure is a highly lethal disease affecting more than million adults in t ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Recombinant Silk Elastin-like Protein Polymers for the Embolization of Cerebral Aneurysms

    SBC: THERATARGET, INC.            Topic: 106

    NARRATIVE This STTR Phase I proposal details the rationale and the research plan for the development of a novel liquid embolizing agent composed of the genetically engineered protein polymerSELPsilk elastinlike proteinKto embolize cerebral aneurysmsThe SELP embolic would reduce the risk of aneurysm rupture while minimizing the risk of recanalization after treatment and providing a platform for del ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Preparation of site specific antibody drug conjugates by proximity based sortase ligation

    SBC: ALPHATHERA            Topic: 103

    There has been growing interest in the use of antibody drug conjugates ADCs for the treatment of cancer as mounting data suggests an increase in anti tumor effectiveness and reduced toxicity compared with the administration of unlabeled antibodies in combination with chemotherapy The two ADCs that are currently approved by the FDA brentuximab vedotin Adcetris and ado trastuzumab emtansin ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Effects of LGM on a Primate Model of Asthma

    SBC: Lignamed, LLC            Topic: NIAID

    PROJECT SUMMARY We previously demonstrated in mice that the major pathogenic features eosinophilic airway inflammation and airway hyperresponsiveness AHR were markedly enhanced in mice exposed to repeated social stress and these changes were associated with impaired glucocorticoid receptor GR expression and function In studies on non human primates rhesus macaques at the California Natio ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Development and Validation of SafeClose Mesh Augmentation System for Hernia Prevention

    SBC: Paradigm Surgical LLC            Topic: 300

    Incisional hernia IH can be prevented using prophylactic mesh placement PMP which involved placement of mesh to reinforce an abdominal fascia closure before herniation occurs at the index of surgery PMP reduced the absolute risk of IH with an acceptable complication profile Open abdominal surgery techniques remain commonplace and contribute to the estimated cases of IH performed in ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Visually driven disease variant analysis empowering real time clinical research

    SBC: FRAMESHIFT LABS INC            Topic: NHGRI

    Project Summary Identifying disease causing genetic variants is a complex process that requires experts from multiple fields including bioinformatics IT systems administration and disease pathology to work closely together The size of sequencing data files also adds the requirement for large computational resources As a result performing genomic analyses is an ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Biocatalytic production of precursors to lutein and zeaxanthin to address age related macular degeneration

    SBC: EscaZyme Biochemicals, LLC            Topic: N

    Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
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