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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. In Vivo Editing for Hemophilia Gene Therapy

    SBC: GENVEC, INC.            Topic: 100

    Project Summary The exceptional promise of gene therapy for hemophilia has been shown in recent studies that result in long term correction of factor IX deficiency via hepatic transduction with an adeno associated vector AAV In spite of this watershed event in the history of the gene therapy field there presently exist barriers to the fullest implementation of hemophilia gene therapy The li ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Trans‐nasal delivery of chemotherapy to glioblastoma using magnetic nanoparticles and magnetic focusing

    SBC: Weinberg Medical Physics, Inc.            Topic: 102

    Abstract Glioblastoma multiforme GBM is the deadliest form of brain tumor The current treatment includes a combination of surgical resection chemotherapy radiation and electrical disruption of mitosis has only extended survival to approximately to years Preliminary pre clinical findings suggest the potential effectiveness of the candidate drug cyclopamine However the drug is toxic to ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Polyionic Papillomavirus like Particles VLP for the Treatment of HPV oropharyngeal squamous cell carcinomas OPCs

    SBC: PATHOVAX, LLC            Topic: 102

    The broader impact commercial potential of PathoVax s STTR phase I proposal is to improve outcomes of cancer immuno therapy utilizing a vaccine formulation combining an immunogenic chimeric virus like particle cVLP vaccine with FDA approved immune check point inhibitors PathoVax proposes to develop this technology for treatment of human papillomavirus HPV associated cancers However cancer ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Assessing Skills and Treatment Progress in Basic Communicators of All Ages The Basic Social and Communication Behavior Scales BSCBS Phase I

    SBC: PAUL H BROOKES PUBLISHING CO., INC.            Topic: NIDCD

    Project Summary Abstract Effective communication intervention depends on reliable tools for identifying communication concerns and tracking changes in skills Established tools for detecting and tracking skills in early intentional communicators i e directing a behavior such as reaching toward an adult to convey a message involve communication temptations and assessing a wide variety of child ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Biocatalytic production of precursors to lutein and zeaxanthin to address age related macular degeneration

    SBC: EscaZyme Biochemicals, LLC            Topic: N

    Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Virtual reality games to assess and habilitate auditory spatial awareness

    SBC: VisiSonics Corporation            Topic: NIDCD

    Project Summary Virtual reality games to assess and habilitate auditory spatial awareness Auditory spatial awareness ASA is the critically important skill of using sound to understand extrapersonal space and its content Both explicit sound localization and implicit environmental awareness aspects of ASA contribute to everyday listening effort fatigue and spatial attention Because heari ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. A Systematic Medical Approach to Reward Transformation SMART for Brain Health in Opioid Use Disorder

    SBC: Versa Integrated Solutions, Inc.            Topic: 102

    Summary In recent years opioid use disorder OUD and deaths due to opiate overdose e g with heroin fentanyl oxycodone in suburban and rural non minority groups has created an urgency for approaches to stem this epidemic but the rise in OUD and opiate overdose deaths has occurred in inner cities at similar rates Heroin misuse and addiction are persistent problems in African American commu ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Physics-Based and Computationally Efficient Combustion Chemistry Modules with Acceptable Uncertainty for Air Force Relevant Hydrocarbon Fuels

    SBC: COMBUSTION SCIENCE & ENGINEERING, INC.            Topic: AF17AT004

    The overall goal of this project is to validate and enhance the latest available combustion kinetics models for fuels that are of relevance to the Air Force propulsion systems. To achieve this goal, Combustion Science & Engineering, Inc. and Stanford University will focus on evaluating the performance of the existing jet fuel models using selected experimental data from the literature. Sensitivit ...

    STTR Phase I 2017 Department of DefenseAir Force
  9. Subspace Tracking and Manifold Learning Based Heterogeneous Data Fusion for Unexpected Event Discovery

    SBC: INTELLIGENT FUSION TECHNOLOGY, INC.            Topic: AF16AT12

    In many DoD intelligence, surveillance, and reconnaissance (ISR) scenarios, the data streams not only have a high dimensionality, but also belong to different sensing modalities. Current ISR surveillance typically employs stove-piped exploitation systems. Based on a single sensing modality, a stove-piped system senses, captures, and processes only one kind of target signal or signature. IFT propos ...

    STTR Phase II 2017 Department of DefenseAir Force
  10. High Performance and Novel Target Recognition Algorithm in the Sparse Measurement Space

    SBC: APPLIED RESEARCH LLC            Topic: AF15AT27

    This Phase II project focuses on the development of a compact, light-weight, low cost, low power, high resolution, high frame rate, low motion blur, and high dynamic range (HDR) imager for target recognition. We have both innovative hardware and software algorithms. In the hardware, we propose an advanced compressive sensing CMOS imager that has several key features. First, the imager has pixel-wi ...

    STTR Phase II 2017 Department of DefenseAir Force

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