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Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...

PROJECT SUMMARY The drug development pipeline is plagued by unacceptable rates of attrition due in large part to toxicities that are not identified in pre clinical stages of developmentThe ability to de risk lead compounds during pre clinical development with advancedorganoid on a chiptechnologies shows tremendous promiseDrug induced neurotoxicity is caused by off target effects of pharmaceuticals ...

Space platforms are complex dynamical systems and there are many reasons to model them from ground telescope imagery as well as from space-based sensor platforms. One key motivation is to determine the operational state and configuration of the vehicle. Key questions such as did the solar panels fail to deploy, did the object begin to tumble unexpectedly may be addressed by a sufficiently detaile ...

A scalable hybrid lithium ion battery / super capacitor energy storage device is developed and the technology is matured such that the system reduces battery cell stress, improves temperature range, and increases effective battery lifetime and safety. This is an enabling technology that allows the use of very high energy batteries in applications that would otherwise be unsuitable for them.

This Small Business Technology Transfer (STTR) Phase I effort will demonstrate the feasibility of a novel passively adaptive shock and vibration isolating buffer system for the US Navys combatant craft. The proposed approach does not rely on conventional passive, semi-active or active spring-damper systems. The buffer system will provide energy damping via a liquid spring buffer and eddy current d ...

This program proposes to develop a photonic integrated circuit with compressive sampling using excitable lasers and neural network process. Compressive sampling overcomes the limitation of traditional approach to analog-to-digital conversion, and provides 2 to 10 folds of energy reduction and has low latency. Using excitable laser is an innovative approach that is fundamental to provide the simple ...

Nevada Composites has developed Green-Aero(sm) toolinglightweight ceramic tooling that is stable under high pressure and long-duration cure cycles and can be washed out with water after cures to 370C (700F). Tools, whether single-sided or washout, have a composite-compatible CTE, provide tight tolerances, are reproducible, are stable to storage under ambient conditions, and are of affordable cost. ...

This Phase II STTR effort is focused on generating the data necessary to identify the phenomenology that produces carbon deposition within kerosene film cooled rocket engines.This data is essential to guide the model development and validation process.Program outputs will be both data and a physics-based model for carbon deposition.

ABSTRACT: Sierra Engineering Inc. (Sierra) believes that existing chemical kinetic models can be efficiently incorporated into commercial CFD codes to predict the mixing, pyrolysis, soot formation and carbon deposition within film cooled rocket engines. During this Phase I STTR effort we will demonstrate that this analysis capability is practical and that we can generate appropriate model validati ...

A hybrid lithium ion battery / super capacitor energy storage device is developed that uses the high power capability of the super capacitor to satisfy pulsed power load requirements such that stress on the lithium ion batteries is reduced. This results in extended discharge time and higher efficiency utilization of the battery stack.