Award Data

Project Abstract Active surveillance (AS) is becoming more accepted as a reasonable treatment option for men with low-risk prostate cancer (i.e. Gleason score 6, clinical stage T2a, PSA lt 10). Many AS protocols at major institutions call for a prostate saturation biopsy after initial diagnosis to confirm that the patient has no areas of higher-risk prostate cancer. For most patients who underwent ...

The long term goal of the proposed project is the development of a desktop circular array Small Animal Ultrasound Tomography System SAUTS to produce high resolution cross sectional diagnostic images of mice and other small laboratory animals The SAUTS images will look familiar to the radiologist resembling those produced by Micro CT or MRI They will be easy to interpret as the circular tomog ...

DESCRIPTION provided by applicant The long term goal of this project is to develop prosthetic foot technology that can function differently for different activities Although current prostheses can be very effective for particular tasks e g walking running or standing an amputee must choose a single prosthesis to achieve reasonably good performance across all daily activities This resul ...

ABSTRACT: Cyber warfare presents a persistent and evolving threat to military and civilian information systems. Would-be cyber attackers are constantly changing their attack vectors to take advantage of security lapses by human resources and the latest vulnerabilities in information technology. To train the warfighter to combat this threat Soar Technology in partnership with KAB Laboratories and ...

DESCRIPTION (provided by applicant): We propose a completely new, low cost and robust bactericidal urinary 100% silicone Foley catheter with a gt3-6 month shelf-life, that will utilize electromodulated delivery of nitric oxide (NO) for up to 45-60 d to serve as a potent antimicrobial/antibiofilm agent. The first generation device will possess a stable inorganic nitrit salt reservoir within on lume ...

DESCRIPTION provided by applicant In Phase I Biocrede developed a completely new urinary tract silicone Foley catheter with a andgt month shelf life made from a proprietary polymeric formulation to effectively reduce catheter associated urinary tract infections CAUTI via nitric oxide NO release for andgt weeks Key features of the new technology include catheters continuously d ...

Abstract Applications of customizable nucleases such as CRISPR clustered regularly interspaced short palindromic repeats Cas CRISPR associated protein have enabled efficient and precise gene correction in vitro and hold promises for eventually achieving in vivo gene correction therapy However to apply CRISPR Cas in therapeutic settings several major challenges remain to be addressed ...

DESCRIPTION (provided by applicant): The central dogma of molecular biology has undergone a significant revision where RNAs have emerged as important regulators of cell activity. Astonishingly, as much as 80% of human DNA is transcribed into RNA as recently reported by the Encyclopedia of DNA Elements (ENCODE) consortium. New classes of RNA are being identified including many which are non-protein ...

DESCRIPTION provided by applicant The central dogma of molecular biology has undergone a significant revision where RNAs have emerged as important regulators of cell activity Astonishingly as much as of human DNA is transcribed into RNA as recently reported by the Encyclopedia of DNA Elements ENCODE consortium New classes of RNA are being identified including many which are non protein ...

Toxins pharmaceuticals and physiologically indogenous compounds are metabolized by the liver via several classes of enzymes The uridine diphosphate glucuronosyltransferases UGTs are concentrated in the liver but also present in other tissues These enzymes add UDP glucuronic acid UDPGA to a compound thereby increasing its solubility and ability to be excreted in the bile and urine Oxford B ...