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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. A NOVEL TARGETED DELIVERY SYSTEM FOR CANCER TREATMENT AND DIAGNOSIS

    SBC: ENDURX PHARMACEUTICALS INC            Topic: NCI

    DESCRIPTION (provided by applicant): Glioblastoma multiforme (GBM) or glioblastoma, is the most common and aggressive malignant primary brain tumor in humans. An effective treatment that increases patient survival would represent a significant advance inthe field, and provide a desperately needed new therapy for this deadly disease. EnduRx is focused on the development of new, targeted systems f ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  2. A Novel Therapeutic Antibody for Age-related Macular Degeneration

    SBC: Charlesson, LLC            Topic: W

    DESCRIPTION provided by applicant Age related macular degeneration AMD is a common disease of the central retina and remains a leading cause of vision loss and blindness in elderly Americans Currently the standard of care for wet AMD is intravitreal vascular endothelial growth factor VEGF inhibitors However these therapies are not always effective in all patients AMD is a multi factori ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. A Pintle-Free Divert and Attitude Control System

    SBC: Digital Solid State Propulsion, Inc            Topic: AF141137

    ABSTRACT: Digital Solid State Propulsion is proposing to develop a Divert and Attitude Control System (DACS) for tactical air superiority missiles, using proprietary Electric Solid Propellants (ESPs). Unlike conventional propellants, ESPs can be ignited with electric power applied through inert electrodes within the propellant grain itself, while also maintaining a higher level of insensitivity. ...

    SBIR Phase I 2014 Department of DefenseAir Force
  4. A Wnt Modulator for Treatment of Age-related Macular Degeneration

    SBC: Charlesson, LLC            Topic: NEI

    PROJECT SUMMARY/ABSTRACT Age-related macular degeneration (AMD) is characterized by progressively decreased central vision and visual acuity and remains a leading cause of vision loss and blindness in aged Americans. Currently, the standard of care for AMD is intravitreal vascular endothelial growth factor (VEGF) inhibitors. Clinical studies have demonstrated that anti-VEGF drugs can slow or reve ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Bayesian Inference of Spacecraft Geometry and Pose

    SBC: VISION SYSTEMS INC            Topic: AF17AT007

    Space platforms are complex dynamical systems and there are many reasons to model them from ground telescope imagery as well as from space-based sensor platforms. One key motivation is to determine the operational state and configuration of the vehicle. Key questions such as did the solar panels fail to deploy, did the object begin to tumble unexpectedly may be addressed by a sufficiently detaile ...

    STTR Phase I 2017 Department of DefenseAir Force
  6. Biocatalytic production of precursors to lutein and zeaxanthin to address age related macular degeneration

    SBC: EscaZyme Biochemicals, LLC            Topic: N

    Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Calcaftor, a CFTR stabilizer for Cystic Fibrosis treatment

    SBC: CALISTA THERAPEUTICS INC            Topic: NIDDK

    DESCRIPTION (provided by applicant): Calista Therapeutics has invented Calcaftor, a first-in-class peptide drug that can treat all Cystic Fibrosis (CF) patients. Calcaftor is validated in the gold standard pre-clinical model of CF using F508 -CFTR lung tissue harvested from CF transplant patients. Results from this model demonstrated a gt25 hour duration of action that enables once daily inhaled n ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Computational tools for reliable prediction of complex hypersonic flows

    SBC: Next Frontier LLC            Topic: AF17AT014

    In order to enable reliable predictions based on full scale vehicle simulations relevant to high-speed ISR missions, detailed interactions among various nonequilibrium physical phenomena and their coupling to turbulent flow structures, characterized by a broad range of length/time scales, need to be accurately modeled. Although detailed predictions can be obtained using detailed state-to-state kin ...

    STTR Phase I 2017 Department of DefenseAir Force
  9. Developing A Novel Therapy for Diabetic Retinopathy

    SBC: Charlesson, LLC            Topic: W

    DESCRIPTION provided by applicant Diabetic retinopathy DR is a common complication of diabetes and a leading cause of vision loss in the United States Although the anti vascular endothelial growth factor VEGF drugs have shown impressive efficacies on wet age related macular degeneration AMD they are only effective in approximately of patients with DR likely due to the multi factori ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  10. Developing Testing and Validating a Wearable Alcohol Biosensor

    SBC: Clinitech, LLC            Topic: 450

    PROJECT SUMMARY This application for a Phase I SBIR award represents a collaboration between Clinitech LLC and McLean Hospital Harvard Medical School to develop a wearable biosensor for detecting alcohol in the interstitial fluid of humans who have consumed alcohol Excessive use of alcohol accounts for much of the public health burden related to alcohol use disorders including fetal ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
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