Award Data

Additive manufacturing (AM) technologies covering a broad range of technologies and processes have been under continuous and accelerating development since the 80s. While there are still fundamental hurdles such as low production rates and small sizes, AM holds tremendous promise in terms of revolutionizing manufacturing. Recent trends include direct-printing and incorporating sensors and electr ...

DESCRIPTION (provided by applicant): Current approaches to medical education produce new physicians with insufficient clinical competency to practice effectively with limited supervision, which has serious implications for patient outcomes during hospitaloff hours. Up to 70% of patients admitted to a hospital are admitted on nights or weekends, when staffing is low and residents may be in charge o ...

Project Summary Today s clinical learning environments do not provide the level of deliberate practicedirect supervisionand rigorous assessment and feedback needed to develop diagnostic reasoning expertiseClinical performance assessment emphasizes learner evaluation over learner developmentlacks rigor and utility for developmental purposesand clinical teachers have expressed particular difficulty ...

DESCRIPTION provided by applicant Anasys Instruments and Prof Lynne Taylor of Purdue propose to develop nanoscale chemical characterization capabilities for drug formulation research This project will build on successful Phase I research demonstrating feasibility of atomic force microscope based infrared spectroscopy AFM IR in pharmaceutical applications This Phase II research will advance ...

DESCRIPTION provided by applicant The broad objective of this project is to develop an integrated wet lab dry lab kit for high throughput detection of RNA modifications The final product will provide all required molecular biology reagents a set of simple and robust experimental manipulations for facile analysis of modifications and researcher friendly analytic cloud based software requi ...

DESCRIPTION provided by applicant Preeclampsia is a pregnancy specific hypertensive disorder that can lead to multi organ failure seizure and maternal death Preeclampsia is also responsible for as many as of premature births in the United States Although better neonatal care has improved the likelihood of preterm babies surviving many face increased mortality and serious long term mor ...

Adaptive Optics allow ground-based astronomical observatories to overcome atmospheric distortion limited observation by using natural and artificial guide stars to measure the distortion. Sodium-layer guide stars provide near all-sky coverage for high resolution astronomy. Over the last 20 years, Optically Pumped Semiconductor Laser (OPSL), also referred to as Vertically Extended Cavity Surface ...

DESCRIPTION provided by applicant We have shown that immunization of rabbits with multiple antigenic peptides MAPs displaying sequence from domain of protective antigen PA elicit antibodies specific for a linear determinant within the loop of PA that mediate potent neutralization of lethal toxin LeTx in vitro We have now shown in two separate large studies that antibodies aga ...

DESCRIPTION (provided by applicant): Target enrichment for next-generation sequencing enables researchers to reduce the burden of sequence data analysis, obtain higher levels of statistical significance by examining more genomes and increase sequencing coverage depth. The goal of this STTR proposal is to develop and commercialize a novel technology capable of amplification-free megabase target seq ...

The aerothermal environment for hypersonic flight vehicles is severe and can generate extremely high material temperatures. These high-temperature environments can cause intense localized heating, which may result in local pockets and/or structural instabilities, especially at vehicle leading-edge regions, and may lead to disruptions that affect vehicle performance. The aerothermal environment may ...