Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Galectin 1: A novel small protein therapy for Duchenne muscular dystrophy

    SBC: STRYKAGEN CORPORATION            Topic: NIAMS

    DESCRIPTION provided by applicant Duchenne Muscular Dystrophy DMD is a fatal muscle disease affecting in every male births DMD results from mutations in the gene encoding the dystrophin a kDa scaffolding protein responsible for providing a mechanical link between the muscle fiber actin cytoskeleton and a transmembrane protein complex called the dystrophin associated glycoprotein ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  2. Optimization of an integrin enhancing molecule for the treatment of Duchenne muscular dystrophy

    SBC: STRYKAGEN CORPORATION            Topic: NIAMS

    DESCRIPTION provided by applicant Duchenne muscular dystrophy is caused by mutations in the dystrophin gene resulting in the loss of the dystrophin glycoprotein complex in skeletal muscle Loss of dystrophin results in reduced sarcolemmal integrity progressive muscle damage and compromised muscle function There is currently no cure and limited treatment options for DMD and all affected child ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. Identification of Borrelia burgdorferi diagnostic biomarkers in humans and nonhum

    SBC: DxDiscovery Incorporated            Topic: NIAID

    DESCRIPTION provided by applicant The number of Lyme disease cases in the US has been recently estimated by the CDC at cases year This is major public health concern Currently available diagnostics rely on detection of the antibody response serology to Borrelia burgdorferi the causative agent of Lyme disease However serological tests are not accurate during the early stages of Ly ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  4. Osteopontin targeted therapy for primary CNS lymphoma

    SBC: MODULATION THERAPEUTICS, INC.            Topic: 102

    Abstract Primary central nervous system lymphoma PCNSL is an aggressive brain tumor with a dire unmet therapeutic need It has an overall incidence of per person years and is regarded as an orphan disease with potential for fast track approval Our group made a discovery via gene expression analysis that osteopontin OPN is the most upregulated gene in PCNSL compared to its non CNS ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Developing Multi-targeting Antiviral Agents Against Herpes Simplex 1

    SBC: Quercus Molecular Design, LLC            Topic: NIAID

    Viruses from the human herpesvirus family are estimated to infectof the adult population worldwide and are responsible for lifelong debilitating and congenital infectionsSome members of this family are associated with human cancers and age related cognitive declineHerpes simplex virusHSVhas infected more thanbillion people under the age ofof the populationHSVcauses significant disease during acute ...

    STTR Phase I 2017 Department of Health and Human Services
  6. Biocatalytic production of precursors to lutein and zeaxanthin to address age related macular degeneration

    SBC: EscaZyme Biochemicals, LLC            Topic: N

    Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Prediction and Measurement of the Carbon Build-Up in Film-Cooled Rocket Engines

    SBC: SIERRA ENGINEERING, INC.            Topic: AF15AT21

    ABSTRACT: Sierra Engineering Inc. (Sierra) believes that existing chemical kinetic models can be efficiently incorporated into commercial CFD codes to predict the mixing, pyrolysis, soot formation and carbon deposition within film cooled rocket engines. During this Phase I STTR effort we will demonstrate that this analysis capability is practical and that we can generate appropriate model validati ...

    STTR Phase I 2015 Department of DefenseAir Force
  8. Compact Passive Millimeter Wave Sensor for GPS-denied Navigation

    SBC: Phase Sensitive Innovations, Inc.            Topic: AF15AT26

    ABSTRACT: Under the proposed effort, PSI will leverage a novel pmmW imaging technology developed under a prior Navy program to realize the low size, weight, and power sensors required for UAV implementation. This technology is based on an optical upconverted distributed aperture technology that can make use of the full aperture of the aircraft thereby maximizing achievable resolution. This sensor ...

    STTR Phase I 2015 Department of DefenseAir Force
  9. Instant k-Space Tomography for Spatial-Spectral Monitoring

    SBC: Phase Sensitive Innovations, Inc.            Topic: AF17AT013

    The Army is frequently forced to operate in hostile climates. Heavy fog, rain, snow, and dust storms can inhibit the performance of tracking technologies such as mid-wave infrared cameras. In such conditions, Army early warning systems are blinded and put personnel and assets at risk. There is a specific need for a degraded visual environment (DVE) penetrative target tracking solution. Radio fre ...

    STTR Phase I 2017 Department of DefenseAir Force
  10. Compact Passive Millimeter Wave Sensor for GPS-denied Navigation

    SBC: Phase Sensitive Innovations, Inc.            Topic: AF15AT26

    Under the proposed effort, PSI will leverage a novel pmmW imaging technology developed under a prior Navy program to realize the low size, weight, and power sensors required for UAV implementation.This technology is based on an optical upconverted distributed aperture technology that can make large effective apertures in low SWaP form factors thereby maximizing achievable resolution.This sensor te ...

    STTR Phase II 2017 Department of DefenseAir Force
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