Award Data

Optical components for RF-photonic applications such as communication satellites, avionics, optical networks, sensors and phase array radar will require high speed, high capacity and low power. Due to the nature of crystalline electro-optic materials (LiNbO3, GaAs, InP, etc.) today’s commercial electro-optical devices do not perform well above 40 GHz. This limitation can be circumvented by utili ...

This proposal deals with advanced design architectures for realizing silicon-based reconfigurable and stackable photonic analog signal processing engines supported on flexible or flat substrates using crystalline Si-based nanomembrane technology. Silicon nanomembranes are single crystals of Si that have been released from SOI substrates and redeposited on foreign flexible or flat substrates enabli ...

Many large-scale numerical simulations can be broken down into common mathematical routines. While the applications may differ, they often need to perform standard functions such as system solves, Fourier transforms, or eigenvalue calculations. Consequently, producing fast, efficient implementations of these methods will benefit a broad range of Air Force applications. Graphics Processing Units (G ...

DESCRIPTION (provided by applicant): Anthrax is recognized as a class A bio-threat microbial pathogen that is readily weaponized and exceedingly difficult to treat. This bacterium is highly virulent inducing lethal infection in immunologically normal hosts by its intrinsic capacity to disseminate rapidly and induce sepsis, along with its ability to generate two highly potent exotoxins, lethal toxi ...

ABSTRACT: Sierra Engineering Inc. (Sierra) believes that existing chemical kinetic models can be efficiently incorporated into commercial CFD codes to predict the mixing, pyrolysis, soot formation and carbon deposition within film cooled rocket engines. During this Phase I STTR effort we will demonstrate that this analysis capability is practical and that we can generate appropriate model validati ...

ABSTRACT: Under the proposed effort, PSI will leverage a novel pmmW imaging technology developed under a prior Navy program to realize the low size, weight, and power sensors required for UAV implementation. This technology is based on an optical upconverted distributed aperture technology that can make use of the full aperture of the aircraft thereby maximizing achievable resolution. This sensor ...

DESCRIPTION provided by applicant Duchenne Muscular Dystrophy DMD is a fatal muscle disease affecting in every male births DMD results from mutations in the gene encoding the dystrophin a kDa scaffolding protein responsible for providing a mechanical link between the muscle fiber actin cytoskeleton and a transmembrane protein complex called the dystrophin associated glycoprotein ...

DESCRIPTION provided by applicant Duchenne muscular dystrophy is caused by mutations in the dystrophin gene resulting in the loss of the dystrophin glycoprotein complex in skeletal muscle Loss of dystrophin results in reduced sarcolemmal integrity progressive muscle damage and compromised muscle function There is currently no cure and limited treatment options for DMD and all affected child ...

DESCRIPTION provided by applicant The number of Lyme disease cases in the US has been recently estimated by the CDC at cases year This is major public health concern Currently available diagnostics rely on detection of the antibody response serology to Borrelia burgdorferi the causative agent of Lyme disease However serological tests are not accurate during the early stages of Ly ...

Abstract Primary central nervous system lymphoma PCNSL is an aggressive brain tumor with a dire unmet therapeutic need It has an overall incidence of per person years and is regarded as an orphan disease with potential for fast track approval Our group made a discovery via gene expression analysis that osteopontin OPN is the most upregulated gene in PCNSL compared to its non CNS ...