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Abstract Primary central nervous system lymphoma PCNSL is an aggressive brain tumor with a dire unmet therapeutic need It has an overall incidence of per person years and is regarded as an orphan disease with potential for fast track approval Our group made a discovery via gene expression analysis that osteopontin OPN is the most upregulated gene in PCNSL compared to its non CNS ...

Summary Approximatelymillion women in the United States are at high risk for developing breast cancerbased on inheritance of a germline mutation in a gene in the double strand breakDSBrepair and cyclin checkpoint pathwaysMany are unaware of their genetic predispositionsbecause their family history is uninformative or unknownGenetic testing is important for identifying mutations in these genesbut i ...

Viruses from the human herpesvirus family are estimated to infectof the adult population worldwide and are responsible for lifelong debilitating and congenital infectionsSome members of this family are associated with human cancers and age related cognitive declineHerpes simplex virusHSVhas infected more thanbillion people under the age ofof the populationHSVcauses significant disease during acute ...

Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...

Space platforms are complex dynamical systems and there are many reasons to model them from ground telescope imagery as well as from space-based sensor platforms. One key motivation is to determine the operational state and configuration of the vehicle. Key questions such as did the solar panels fail to deploy, did the object begin to tumble unexpectedly may be addressed by a sufficiently detaile ...

Stellar Science, in collaboration with the University of Maryland, proposes to develop algorithms to demonstrate the feasibility of constructing three-dimensional (3D) models of satellites using ground-based imagery on a standard PC in under 15 minutes. The Phase I effort will address the challenge of registering two-dimensional (2D) images of satellites where traditional feature matchers frequent ...

The Army is frequently forced to operate in hostile climates. Heavy fog, rain, snow, and dust storms can inhibit the performance of tracking technologies such as mid-wave infrared cameras. In such conditions, Army early warning systems are blinded and put personnel and assets at risk. There is a specific need for a degraded visual environment (DVE) penetrative target tracking solution. Radio fre ...

The design ofDeployable Reconfigurable Pixelated Antennas (DERPAs) that can operate at different frequencies,with different radiation patterns, and achieve polarization diversity is proposed.The solution proposed, based on optically pixelated silicon or GaAs surfaces, can be used as reflective surfaces for reconfigurable reflect arrays or as reconfigurable active and modular antennas. The optical ...

Under the proposed effort, PSI will leverage a novel pmmW imaging technology developed under a prior Navy program to realize the low size, weight, and power sensors required for UAV implementation. This technology is based on an optical upconverted distributed aperture technology that can make large effective apertures in low SWaP form factors thereby maximizing achievable resolution. This sensor ...

With today's IRLED devices, >99.4% of input electrical power is converted into parasitic/waste heat. Moreover, as the local temperatures of the pixels increase due to the generated heat, IRLED optical efficiency is further reduced. Overall this severely limits the number and intensity of array pixels that can be simultaneously operated at high apparent temperatures. In Phase 2, we focus on develop ...