Award Data

For best search results, use the search terms first and then apply the filters
Reset

The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. A Multiscale Simulation Framework to Model Energetic Materials Subjected to Shock Loading

    SBC: SIMMETRIX INC.            Topic: AF15AT28

    ABSTRACT: The overall objective of this project is to develop scalable simulation components that effectively model the meso-scale physics of heterogeneous energetic materials subject to dynamic shock loading including matrix debonding, void collapse, and damage due to crystal to crystal interactions, and bridges the meso-scale to the macro-scale for system scale simulations of the transition to d ...

    STTR Phase I 2015 Department of DefenseAir Force
  2. A Novel Approach to Purifying iPSC Derived Cell Cultures

    SBC: HocusLocus Inc.            Topic: 200

    DESCRIPTION provided by applicant We are pioneering an RNA based switch technology called structurally interacting RNAs sxRNA which utilizes post transcriptional gene regulation as a reporter for miRNA detection Normally RNA binding proteins RBP associate with a andapos stem loop structure to facilitate translation of an upstream coding region by as much as an order of magnitude It is ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. A Novel Polymeric Valve for Transcatheter Aortic Valve Replacement

    SBC: POLYNOVA CARDIOVASCULAR INC            Topic: NHLBI

    Project SummaryA Novel Polymeric Valve for Transcatheter Aortic Valve Replacement Minimally invasive transcatheter aortic valve replacementTAVRhas emerged as an effective therapy for the unmet clinical need of inoperable patients with severe aortic stenosisASRecent longitudinal follow up studies of TAVR patients however indicate that this procedure and associated technology may result in serious a ...

    STTR Phase I 2017 Department of Health and Human Services
  4. A novel product for tendinopathy treatment

    SBC: NEW YORK R&D CENTER FOR TRANSLATIONAL MEDICINE AND THERAPEUTICS, INC.            Topic: NIA

    Project Summary This study aims to prove the concept and feasibility that TendonCure extracellular vesicles that contain signaling molecules i e exosomes secreted by mesenchymal stem cells i e tendon stem progenitor cells TSPCs or adipose derived stem cells ADSCs from individual patients donors cultured on a novel scaffold exert therapeutic efficacy on tendinopathy when injected into ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Active Control of Scramjet Isolator Shocks (ACSIS)

    SBC: Innoveering, LLC            Topic: AF15AT19

    ABSTRACT: Active control of the shock system in a scramjet engine isolator opens possibilities for enhanced engine performance and reduced engine weight by eliminating excess isolator design margin. A successful system will allow for maximum performance from a given engine configuration and will deliver range and efficiency that exceeds those possible using passive unstart control. Our approach is ...

    STTR Phase I 2015 Department of DefenseAir Force
  6. Automated Assessment of Leptomeningeal Collaterals on CT Angiograms

    SBC: Kitware, Inc.            Topic: 108

    DESCRIPTION provided by applicant The primary goal of this study is to develop an automated scoring system of leptomeningeal collaterals based on CT angiography CTA as a quantitative assessment of acute stroke Leptomeningeal collaterals provide an alternate path of blood flow in the setting of a proximal occlusion The presence and effectiveness of leptomeningeal collaterals i e andquot c ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  7. Bayesian Inference of Spacecraft Geometry and Pose

    SBC: VISION SYSTEMS INC.            Topic: AF17AT007

    Space platforms are complex dynamical systems and there are many reasons to model them from ground telescope imagery as well as from space-based sensor platforms. One key motivation is to determine the operational state and configuration of the vehicle. Key questions such as did the solar panels fail to deploy, did the object begin to tumble unexpectedly may be addressed by a sufficiently detaile ...

    STTR Phase I 2017 Department of DefenseAir Force
  8. Biocatalytic production of precursors to lutein and zeaxanthin to address age related macular degeneration

    SBC: EscaZyme Biochemicals, LLC            Topic: N

    Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Biomimetic Material Solutions for the Stabilization of Labile Reagents

    SBC: Carrera Bioscience Inc.            Topic: AF15AT29

    ABSTRACT: A platform (PHA-fuse) for the stabilization of diagnostic and therapeutic reagents will be established based upon the polymer, polyhydroxyalkanoate (PHA). Fusions of a target molecule to PHA synthase, the enzyme responsible for PHA synthesis, will be constructed and used to catalyze the synthesis of PHA granules. These PHA granules will help stabilize the fused target molecules and elimi ...

    STTR Phase I 2015 Department of DefenseAir Force
  10. Broad-Spectrum PV Devices Based on Charged Quantum Dots

    SBC: Optoelectronic Nanodevices LLC            Topic: AF13AT13

    ABSTRACT: This project addresses the need for high-efficiency broad-spectrum PV cells. The proposed original PV design is based on quantum dots with built-in charge (Q-BIC), where the dot charging is realized by selective doping of dot medium. The preliminary data demonstrate that the charged dots placed in a single p-n-junction strongly enhance harvesting and conversion of sub-bandgap photons an ...

    STTR Phase I 2014 Department of DefenseAir Force
US Flag An Official Website of the United States Government