Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Preclinical Development of a Novel Small Molecule Drug for Sepsis

    SBC: THERASOURCE, LLC            Topic: 300

    PROJECT DESCRIPTIONThis STTR Phase I proposal is intended to demonstrate the feasibility of developing tanshinone small molecule analogTSAas an effective and safe small molecule therapy for patients with sepsis and septic shockIn the USmore than one million people develop sepsis every yearYetno effective anti sepsis treatment exists other than antibiotics and supportive careWe have discovered that ...

    STTR Phase I 2017 Department of Health and Human Services
  2. Discovery of Novel Drugs for Autism

    SBC: ASDDR, LLC            Topic: 101

    Summary The goal of this study is to discover novelmechanism based pharmacological intervention for autisma devastating neurodevelopmental disorder with no treatment currentlyGenetic sequencing has revealed extensive overlap in risk genes for autism and for cancermany of which are chromatin remodeling factors important for transcriptional regulationsuggesting the possibility of repurposing the ant ...

    STTR Phase I 2017 Department of Health and Human Services
  3. A novel product for tendinopathy treatment

    SBC: NEW YORK R&D CENTER FOR TRANSLATIONAL MEDICINE AND THERAPEUTICS, INC.            Topic: NIA

    Project Summary This study aims to prove the concept and feasibility that TendonCure extracellular vesicles that contain signaling molecules i e exosomes secreted by mesenchymal stem cells i e tendon stem progenitor cells TSPCs or adipose derived stem cells ADSCs from individual patients donors cultured on a novel scaffold exert therapeutic efficacy on tendinopathy when injected into ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Microfabrication based Biomimetic Approach for In Vitro Red Blood Cell Maturation

    SBC: Simpore Inc.            Topic: NHLBI

    Abstract The overall goal of this proposal is to develop systems for efficient ex vivo maturation of functional human red blood cells RBCs which holds tremendous potential for addressing supply bottlenecks for delivering new therapeutic options to chronically transfused patients with severe alloimmunization and for novel strategies for delivering therapeutics via engineered RBCs No approaches ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Structure based optimization of a novel pharmacological chaperone therapy for MPSIIIC

    SBC: Phoenix Nest Inc.            Topic: NICHD

    PROJECT SUMMARY Lysosomal storage diseases LSD are rare inherited metabolic disorders caused by defects in the cellular catabolic system Mucopolysaccharidosis Type IIIC MPS IIIC or Sanfilippo disease type C is one such LSD that is caused by deficiency of the enzyme heparan sulfate acetyl CoA glucosaminide N acetyltransferase HGSNAT essential for degradation of heparan sulfate a repeati ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Biocatalytic production of precursors to lutein and zeaxanthin to address age related macular degeneration

    SBC: EscaZyme Biochemicals, LLC            Topic: N

    Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Jamboxx: Interactive Respiratory Therapy through Music and Gaming

    SBC: My Music Machines Inc.            Topic: NHLBI

    Project SummaryAbstract The goal of this project is to develop a novel device for respiratory therapy that uses interactive gaming and music to encourage patient complianceIn order to maintain pulmonary healthmany post operative surgery patients as well as people with quadriplegia and other spinal cord injurieshigh level motor neuron diseases such as amyotrophic lateral sclerosisALSand multiple sc ...

    STTR Phase II 2017 Department of Health and Human Services
  8. Improvements to Biopharmaceutical Manufacturing

    SBC: HocusLocus Inc.            Topic: 400

    PROJECT SUMMARY Over $billion dollarsworth of biological productsincluding antibodiesvaccines and proteinsare produced each yearThis continues to grow worldwide at aboutyearmaking biopharmaceuticals a fairly recession proofgrowing and pro table industryThis shift towards biopharmaceuticals re ects a fundamental shift within the pharmaceutical industryBiomanufacturers are under constant pressure to ...

    STTR Phase II 2017 Department of Health and Human Services
  9. A Novel Polymeric Valve for Transcatheter Aortic Valve Replacement

    SBC: POLYNOVA CARDIOVASCULAR INC            Topic: NHLBI

    Project SummaryA Novel Polymeric Valve for Transcatheter Aortic Valve Replacement Minimally invasive transcatheter aortic valve replacementTAVRhas emerged as an effective therapy for the unmet clinical need of inoperable patients with severe aortic stenosisASRecent longitudinal follow up studies of TAVR patients however indicate that this procedure and associated technology may result in serious a ...

    STTR Phase I 2017 Department of Health and Human Services
  10. Innovative Tools for Three Dimensional Traction Force Microscopy of Single Cells

    SBC: SIMMETRIX INC.            Topic: 102

    Project Summary Tractions exerted by individual cells on their surroundings play a critical role in mechanical events in biology such as tissue contraction folding cell shape changes or cell movements and in many basic cellular functions such as biochemical signaling proliferation and differentiation These processes are in turn implicated in the progression of diseases like cancer atherosc ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
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