Award Data

Advanced Acoustic Concepts, Inc. (AAC) proposes to implement a computational model of human auditory processing based upon cortical theory and to demonstrate its utility to evaluate and improve systems for speech communication and automated recognition ofspectro-temporal patterns. Specifically, AAC believes that unusual brain representations and processing strategies are largely responsible for th ...

DESCRIPTION (provided by applicant): Cloning of the hot and cold thermal receptors has advanced the understanding of the molecular basis of thermal sensation. Two important remaining questions to be addressed are the identification of additional thermal receptor genes and the elucidation of the mechanism(s) that enable the receptor proteins to alter gating properties in response to changes in temp ...

DESCRIPTION (provided by applicant): The goal of this proposal is to evaluate the potential of atiprimod, a drug previously explored for treating rheumatoid arthritis, to treat human multiple myeloma (MM) and other metastatic osteolytic bone diseases. Atiprimod is an orally bioavailable drug that originally completed phase I/lla clinical trials in rheumatoid arthritis patients, with patient exposu ...

Clear Science Corp. and Syracuse University propose to demonstrate the feedback control technologies they developed during Phase I in a series of coordinated Phase II computational and experimental tests. The Phase II objective is validated software thatintegrates reduced-model simulations, CFD simulations, and experimental data into a package for designing fixed-wing aircraft flow control systems ...

Clear Science Corp. and the University of California at Los Angeles propose to develop a versatile and comprehensive computational toolbox for designing feedback flow controllers in aerodynamic applications. Target objectives include separation control tomanage lift and form drag, control of transition to turbulence, turbulence control to reduce skin friction drag, increase mixing, or reduce heat ...

DESCRIPTION (provided by applicant): Molecular profiling of gene expression is a powerful tool that can be used to stage human tumors and categorize them with respect to projected prognosis and therapeutic responsiveness. This technology has been applied most effectively to leukemias and lymphomas for which it is relatively easy to obtain highly enriched pools of tumor cells. Similar approaches ...

Impact Technologies has teamed with the University of Dayton Research Institute (UDRI) and Professor William Curtin from Brown University to develop an autonomous damage detection, classification, and prognostic system for carbon-fiber-reinforced polymer(CFRP) structures. The proposed approach fuses data and information from a set of optimally placed electrodes and associated electro-mechanical mo ...

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DESCRIPTION (provided by applicant): This Phase I STTR application represents a partnership between a university-based research group (Imaging Science and Information Systems [ISIS] Center, Department of Radiology, Georgetown University) and a small business specializing in open-source software development (Kitware, Inc. of Clifton Park, NY). Over the past 1 1/2years, the ISIS Center has been d ...

DESCRIPTION (provided by applicant): The proposed study seeks to identify the feasibility of adopting a newly developed technology platform (hardware and software) to detect and monitor the response of neoplasms of the breast to neoadjuvant chemotherapy based on analysis of dynamic measures of the vascular response and hemoglobin states. This technology employs nonionizing optical sources and perf ...