Award Data

DESCRIPTION provided by applicant Kinase inhibitors created a new paradigm in chemotherapy and are a major focus of new oncology drug development The Bcr Abl inhibitor imatinib was a breakthrough drug for chronic myelogenous leukemia with overwhelming early results however at least of patients are either intolerant resistant or experience recurrence within years and individual respo ...

Spectral Energies and the University of Notre Dame is developing a new class of point-wise sensors for high-enthalpy conditions that rely on the use of a weakly ionized AC discharge between two electrodes as the main sensing element. The advantages of this approach include a native high bandwidth with a theoretical maximum in excess of 15 MHz and a simple mechanical design that is inherently robus ...

ABSTRACT: Scramjet engines are expected to operate across wide Mach number ranges and typically incorporate isolators to provide sufficient back-pressure margin and prevent unstart. Unfortunately, isolators introduce additional weight and drag, and form multiple shockwave/boundary layer interactions, which degrade the incoming flow. As military requirements become increasingly demanding, an active ...

ABSTRACT: Modern gas-turbine engines designs for the next-generation warfighter need to reduce exhaust gas temperatures to reduce effective thermal footprint thereby improving the mission capability. In such situations, high-altitude engine operation is often limited by the overall combustion efficiency, lean flame blow out (LBO) limit, and combustion instabilities that results in narrower opera ...

The automotive and aerospace industries use topology optimization to minimize structural weight while satisfying functional constraints. However, the industry-standard fictitious material or density approach has been less effective when applied to physics beyond simple structural mechanics. Known issues include: failed numerical convergence or so-called gray material in computed optimal designs, n ...

DESCRIPTION provided by applicant Development of novel lung cancer therapeutics targeting the DNA damage response Abstract Lung tissue is constantly exposed to a wide variety of inhaled chemical agents While the majority of these maybe innocuous those that damage DNA have severe consequences Thus the DNA damage response DDR and DNA repair in these tissues is extremely important The vast ...

Thermoelastic structures poses a critical challenge to designers due to the inherent proportionality of the thermal loading on the structural thickness. This is further exacerbated by structural nonlinearity where any out-of-plane deformation further increases the effective loading on the structure. As a result of this, conventional design optimization procedures, which are typically based on line ...

ABSTRACT: Phosphor materials are currently being utilized in a wide variety of applications. The requirements for phosphors have become more and more stringent with smaller and smaller particles being required. In the Phase I program UES Inc. in collaboration with Penn State University has demonstrated the feasibility of a few approaches for high rate production of high efficiency IR to IR up-con ...

PROJECT SUMMARY Probiotics hold enormous potential for promoting human health and treating disease One major hurdle to many probiotic products is their lack of persistence in the gut Monon Bioventures MBV and their research partners at the Research Institute at Nationwide Childrenandapos s Hospital RINCH are developing a novel enhanced tunable technology called ProNextTM that allows for a ...

ABSTRACT: Physiological and environmental monitoring and telemedicine are becoming important tools. Biomarkers play an important role in diagnosing health conditions and enabling advanced care and monitoring systems implemented through telemedicine. Telemedicine tools are needed to seamlessly interface and communicate the physiological condition of the human body with modern electronics including ...