Award Data

ABSTRACT: Active control of the shock system in a scramjet engine isolator opens possibilities for enhanced engine performance and reduced engine weight by eliminating excess isolator design margin. A successful system will allow for maximum performance from a given engine configuration and will deliver range and efficiency that exceeds those possible using passive unstart control. Our approach is ...

In this Phase II program, Voxtel will design, manufacture, and benchmark-test additive-manufactured (AM) insulators capable of electrical stress greater than 25 kV/mm, for use in high-electric-field applications, such as high-power microwave (HPM) devices. These insulators will sustain vacuum of 10-7 Torr and withstand 20 psi of pressure. To achieve this goal, Voxtel will synthesize readily additi ...

DESCRIPTION provided by applicant Traumatic brain injury TBI is an acquired neurological disorder that can cause long lasting disability with limited treatment options Therefore preventative strategies must be emphasized in high risk activities to reduce the individual and societal burden of this pervasive injury Bicycle activities account for of all sports related TBI with ...

ABSTRACT: The overall objective of this project is to develop scalable simulation components that effectively model the meso-scale physics of heterogeneous energetic materials subject to dynamic shock loading including matrix debonding, void collapse, and damage due to crystal to crystal interactions, and bridges the meso-scale to the macro-scale for system scale simulations of the transition to d ...

DESCRIPTION provided by applicant We are pioneering an RNA based switch technology called structurally interacting RNAs sxRNA which utilizes post transcriptional gene regulation as a reporter for miRNA detection Normally RNA binding proteins RBP associate with a andapos stem loop structure to facilitate translation of an upstream coding region by as much as an order of magnitude It is ...

Project SummaryA Novel Polymeric Valve for Transcatheter Aortic Valve Replacement Minimally invasive transcatheter aortic valve replacementTAVRhas emerged as an effective therapy for the unmet clinical need of inoperable patients with severe aortic stenosisASRecent longitudinal follow up studies of TAVR patients however indicate that this procedure and associated technology may result in serious a ...

Project Summary This study aims to prove the concept and feasibility that TendonCure extracellular vesicles that contain signaling molecules i e exosomes secreted by mesenchymal stem cells i e tendon stem progenitor cells TSPCs or adipose derived stem cells ADSCs from individual patients donors cultured on a novel scaffold exert therapeutic efficacy on tendinopathy when injected into ...

DESCRIPTION provided by applicant Human brain development represents a highly vulnerable time to chemical exposures because immature cells are actively undergoing differentiation into more complex cell types e g neurons astrocytes oligodendroglia to form neural circuits A major reason for this vulnerability is that neuronal differentiation requires critical time dependent changes to the ...

DESCRIPTION provided by applicant APDM is a young company focused on developing and commercializing professional systems using wearable inertial sensors for monitoring of human movement and movement disorders In Phase I we developed the novel Instrumented Stand and Walk test ISAW using APDMandapos s proprietary Opal movement monitors and Mobility Lab system We validated the ISAW by demon ...

DESCRIPTION provided by applicant The primary goal of this study is to develop an automated scoring system of leptomeningeal collaterals based on CT angiography CTA as a quantitative assessment of acute stroke Leptomeningeal collaterals provide an alternate path of blood flow in the setting of a proximal occlusion The presence and effectiveness of leptomeningeal collaterals i e andquot c ...