Award Data

Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...

ABSTRACT SignificanceGravesdiseaseGDone of the most prevalent autoimmune diseasesis caused by stimulating autoantibodiesTSAbto the Thyroid Stimulating Hormone ReceptorTSHRresulting in hyperthyroidismCurrent methods for managing hyperthyroidism in GD target excess thyroid hormone secretion by ablation or removal of the thyroid or by blocking thyroid hormone synthesisEach of these therapies is assoc ...

Gray cast iron piping is the most common pipe material in North America. Based on the high carbon content, graphitic needles or flakes are a common feature in these alloys. As a result, these areas of super-saturated carbon will consistently establish galvanic attack of the adjacent iron matrix, especially when in the presence of most ionic liquids. The localized galvanic potentials create microsc ...

PROJECT SUMMARY This application for a Phase I SBIR award represents a collaboration between Clinitech LLC and McLean Hospital Harvard Medical School to develop a wearable biosensor for detecting alcohol in the interstitial fluid of humans who have consumed alcohol Excessive use of alcohol accounts for much of the public health burden related to alcohol use disorders including fetal ...

Space platforms are complex dynamical systems and there are many reasons to model them from ground telescope imagery as well as from space-based sensor platforms. One key motivation is to determine the operational state and configuration of the vehicle. Key questions such as did the solar panels fail to deploy, did the object begin to tumble unexpectedly may be addressed by a sufficiently detaile ...

Production of hydroxylamine nitrate (HAN) and hydroxyethyl hydrazine nitrate (HEHN) is of great concern for the manufacture of AF-315E. Current stockpiles of heritage ingredients held by AFRL are being depleted and those manufacturers are no longer in exi

Electric vehicles are creating unprecedented demand for lithium. Most lithium is produced from brine resources. Conventional methods for extracting lithium from brines suffer from low lithium recovery and cannot access the expanded resources needed for mass adoption of electric vehicles. The Department of Energy has supported a great variety of projects relate ...

Tracking both the extent of the induced fracture and the distribution of the proppant within the fracture are critical in understanding and optimizing the hydraulic fracture processes. Several groups are studying the use of electromagnetic methods and electrically conductive proppants to image the post-fracture proppant distribution. Interpreting these large-scale electromagnetic surveys will like ...

This Small Business Innovation Research project targets the development of mitigation strategies to decrease mercury and other potential hazardous elements in coal prior to combustion or gasification. The Microbeam team including the University of North Dakota and Envergex, LLC is developing a method of coal beneficiation that not only removes mercury, sulfur and other hazardous trace elements, bu ...

Supported by DOE and NSF SBIR grants for nanomembrane manufacturing and Quality Assurance, Covalent LLC is developing manufacturing methods and materials for a new class of ultra low energy, single atomic layer nanomembranes for Desalination and water purification operating at the lowest possible energy (Topic 15A). The completed membranes are expected to reduce desalination energy requirements b ...