Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Automated Electrophysiology Assessment of Drug induced Cardiotoxicity Based on Parallel Noninvasive Nanoelectrode Array

    SBC: CYION TECHNOLOGIES LLC            Topic: NIBIB

    Summary Drug safety issues pose a serious challenge to the health and well being of patients The development of our innovative technology aims to address a significant gap in the in vitro assessment of drug induced cardiotoxicity which is the number one reason for withdrawals of all marketed drugs as well as the premature termination of promising drug development candidates Pressured by the eno ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Skin Microbiome Editing with Fermentation Initiator

    SBC: Surface Bioadvances, Inc.            Topic: NIAMS

    Abstract Acne dysbiosis is defined as microbial imbalance with the over growth of Propionibacterium acnes P acnes in the acne microbiome We have demonstrated that Staphylococcus epidermidis S epidermidis a probiotic bacterium co existed with P acnes in an acne lesion can exploit the carbohydrate fermentation to produce short chain fatty acids SCFAs and rein in the over growth of P ac ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Novel Treatment for Traumatic Brain Injury

    SBC: Epigen Biosciences, Inc.            Topic: 101

    SUMMARY Traumatic brain injury TBI is a leading contributor to death and disability in the USA yet widely effective treatments remain elusive and except for a lengthy program of rehabilitation no effective treatment for TBI is available Therefore there is a critical need in new therapeutic approaches which can maximally preserve brain tissue and facilitate functional recovery after TBI In ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Development of Pirenzepine for HIV SN

    SBC: WinSanTor, Inc.            Topic: 101

    PROJECT SUMMARY Over million people worldwide including million people in the USA are HIV positive HIV associated sensory neuropathy HIV SN is the most frequent neurological manifestation of HIV and is characterized as a distal symmetrical predominantly sensory polyneuropathy HIV SN may represent clinically indistinguishable neuropathies with distinct pathogenesis a distal axona ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. A Unified System for Wireless Optogenetics and Brain Microdialysis for Small Molecules Prototype Development and Validation

    SBC: AMUZA, INC            Topic: 101

    PROJECT SUMMARY While optogenetics is well suited for understanding the dynamic activity of neural circuits the first central theme of the NIH BRAIN Initiative PAR its neurochemical impacts remain largely uncharacterized due to a lack of appropriate tools Given that the predominant mode of cellular interactions is neurochemical commercial development of such tools will fulfill the ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. A Transparent Surgical Mask to Improve Patient Caregiver Communication Minimize Errors and Increase Patient Satisfaction

    SBC: FaceView Mask, LLC            Topic: 600

    PROJECT SUMMARY Hearing loss innate and acquired occurs in over million Americans and globally in over million people To compensate many with hearing impairment rely on the combination of audio information and visual cues from the face cheeks nose and eyes to facilitate speech understanding In healthcare settings this important visual communication is severely hindered by the ubi ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Next Generation Regenerative Therapy with Pim Enhanced Cardiac Progenitor Cells

    SBC: CardioCreate, Inc.            Topic: NHLBI

    PROJECT SUMMARY Myocardial regenerative therapy is poised to revolutionize the way heart failure is treated but further improvements and enhanced products are needed to make this therapy truly safe and efficacious Our company CardioCreate Inc has pioneered the use of genetic engineering to enhance the regenerative potential of human Cardiac Progenitor Cells CPCs intended for autologous the ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Epigenetic Markers and Sustained Cytoprotection for Stroke Treatment

    SBC: ZYMO RESEARCH CORP.            Topic: 101

    PROJECT SUMMARY ABSTRACT Stroke injury is a process that occurs over a long duration with pathologic changes that result in long term neurologic dysfunction For stroke there exists an important need for a strategy that can provide safe and efficacious stabilization to the hypoperfused brain and initialize long lasting endogenous neuroprotection for prevention of long term neurologic dysfunction ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Automated electrophysiological analysis of neural circuitry using a novel nano electrode array for intracellular recording of membrane potential

    SBC: CYION TECHNOLOGIES LLC            Topic: 101

    Summary Nervous systems process information by integrating the electrical activity of neurons in complex networks The alterations in the flow of electrical activity through neuronal networks of the brain play a causal role in the pathogenesis and or the appearance of symptoms of neurodegenerative and psychiatric diseases A fundamental goal of BRAIN Initiative is therefore to elucidate how the ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Caveolae Targeted Cisplatin Immunoconjugates for Effective Lung Cancer Therapy

    SBC: Cavatar LLC            Topic: 102

    Abstract Caveolae at the endothelial cells surface can selectively rapidly and actively pump targeted antibodies out of the bloodstream and into underlying tissue in vivo even when they are conjugated to high molecular weight cargo Based on this exciting recent discovery we also found that caveolae pumping system enables unprecedented tumor specific targeting and penetration Taken together ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
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