Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Development of Pirenzepine for HIV SN

    SBC: WinSanTor, Inc.            Topic: 101

    PROJECT SUMMARY Over million people worldwide including million people in the USA are HIV positive HIV associated sensory neuropathy HIV SN is the most frequent neurological manifestation of HIV and is characterized as a distal symmetrical predominantly sensory polyneuropathy HIV SN may represent clinically indistinguishable neuropathies with distinct pathogenesis a distal axona ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Biocatalytic production of precursors to lutein and zeaxanthin to address age related macular degeneration

    SBC: EscaZyme Biochemicals, LLC            Topic: N

    Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Breakthrough sub cellular D chemical composition research platform for live cells based on the new invention of nanoscale confocal photothermal IR micro spectroscopy n CPIR

    SBC: Anasys Instruments Corp.            Topic: 100

    Abstract This proposal will lead to a Breakthrough sub cellular D chemical composition research platform for live cells based on the new invention of sub micron confocal photothermal IR micro spectroscopy CPIR Label free sub micron chemical imaging and spectroscopy has long been sought for visualization of biomolecules and materials in complex living systems Many diseases first manifest ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Caveolae Targeted Cisplatin Immunoconjugates for Effective Lung Cancer Therapy

    SBC: Cavatar LLC            Topic: 102

    Abstract Caveolae at the endothelial cells surface can selectively rapidly and actively pump targeted antibodies out of the bloodstream and into underlying tissue in vivo even when they are conjugated to high molecular weight cargo Based on this exciting recent discovery we also found that caveolae pumping system enables unprecedented tumor specific targeting and penetration Taken together ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Skin Microbiome Editing with Fermentation Initiator

    SBC: Surface Bioadvances, Inc.            Topic: NIAMS

    Abstract Acne dysbiosis is defined as microbial imbalance with the over growth of Propionibacterium acnes P acnes in the acne microbiome We have demonstrated that Staphylococcus epidermidis S epidermidis a probiotic bacterium co existed with P acnes in an acne lesion can exploit the carbohydrate fermentation to produce short chain fatty acids SCFAs and rein in the over growth of P ac ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Integrated tools for higher order structure determination by cross link analysis

    SBC: Protein Metrics Inc.            Topic: 100

    Summary The use of mass spectrometry MS for quantitative protein characterization has increased dramatically identifying and quantifying thousands of proteins is no longer a heroic task nor is characterizing therapeutic proteins in detail Due to widely available software quantitative mass spectrometry has become routine and widely used for addressing questions in basic biology translational ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Integrated Platform for Mass Spectrometric Studies of Protein Structure

    SBC: Protein Metrics Inc.            Topic: 100

    Summary Technology for studying the higher order structure HOS of biomolecules encompasses some of the most important tools in all of science and is a highlighted NIGMS research topic Mass spectrometric methods for studying HOS include oxidative footprinting and other methods to covalently label amino acid side chain functional groups and also hydrogen deuterium exchange HDX on protein bac ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. A Unified System for Wireless Optogenetics and Brain Microdialysis for Small Molecules Prototype Development and Validation

    SBC: AMUZA, INC            Topic: 101

    PROJECT SUMMARY While optogenetics is well suited for understanding the dynamic activity of neural circuits the first central theme of the NIH BRAIN Initiative PAR its neurochemical impacts remain largely uncharacterized due to a lack of appropriate tools Given that the predominant mode of cellular interactions is neurochemical commercial development of such tools will fulfill the ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Direct magnetic characterization of individual nanoparticles for optimized diagnostic imaging

    SBC: ODMR Technologies, Inc            Topic: 101

    Project Summary ODMR Technologies Inc and Prof Victor Acostaandapos s group at University of New Mexico UNM are developing a diamond chip platform capable of direct magnetic characterization of individual nanoparticles for optimized diagnostic imaging Our team is a spinoff from academic collaborations in the emerging field of diamond photonic sensors a field we helped create nearly a deca ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Target Tracking via Deep Learning

    SBC: TOYON RESEARCH CORPORATION            Topic: AF17AT027

    Persistent tracking of high-value targets is of great interest for reconnaissance and surveillance applications. In recent work, deep neural networks have demonstrated excellent performance on the popular Visual Object Tracking (VOT) challenge; however, these algorithms have not been tested on applications of interest to the Air Force, such as ground vehicle tracking in video recorded from Unmanne ...

    STTR Phase I 2017 Department of DefenseAir Force
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