Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Engineering probiotics to biosynthesize natural substances for microbiome brain research

    SBC: HGG Research LLC            Topic: R

    PROJECT SUMMARY To advance microbiome brain studies the general goals of this collaborative proposal are to provide services to research community by engineering probiotics e g E coli Nissle EcN Bifidobacteria longum Lactobacillus plantarum to biosynthesize various naturally occurring chemicals as prebiotic probiotic conjugates which will be marketed as important laboratory agents ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Preventing Vascular Complications in Type Diabetes Muscle Metabolic Monitoring

    SBC: Infrared Rx, Inc.            Topic: NIDDK

    Project Summary Abstract While much has been accomplished in managing hyperglycemia morbidity and mortality in patients with type diabetes T D often results from cardiovascular complications Evidence suggests peripheral artery disease and skeletal muscle mitochondrial dysfunction One reason is the lack of reliable tools to characterize skeletal muscle microcirculation and mitochondrial capa ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Small molecule therapy for metastatic prostate cancer

    SBC: MetCure Therapeutics LLC            Topic: 102

    Enzalutamide resistance is a major obstacle in the treatment of metastatic castration resistant prostate cancer mCRPC Recently we developed a small molecule lead compound GH and demonstrated its potent activity against bone metastatic prostate cancer cells In this Phase I STTR application we hypothesize that GH is a novel lead compound with nanomolar potency against enzalutamide resist ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Anti CCL mAb to treat castration resistant prostate cancer

    SBC: JYANT Technologies, Inc.            Topic: 102

    Metastatic castration resistant prostate cancer CRPC PCa accounts for of PCa deaths and is associated with skeletal metastases CRPC affects patients differently making this disease difficult for physicians to provide standardized treatments with similar outcomes Docetaxel can prolong the overall survival in patients with metastatic CRPC but current therapies do not provide a cure Doce ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Monoclonal lamprey VLR antibodies specific for mucin type O linked glycan core structures

    SBC: Novab, Inc.            Topic: 300

    PROJECT SUMMARY We will develop and commercialize to the research community a new class of glycan specific binding reagents that incorporate the recognition function of variable lymphocyte receptors VLRs the antigen receptors of the adaptive immune system of jawless vertebrates lamprey and hagfish Such reagents are essential to detecting localizing quantifying and establishing biological ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Large Scale Preparation of Natural Glycans

    SBC: Natglycan, LLC            Topic: 400

    Project Summary Abstract The two major obstacles to progress in glycomics relative to proteomics and genomics are the lack of simple robust and automated methods for determining glycan structures and for synthesis of glycans The net result of this situation is an overall lack of defined glycans for use in functional studies and for use as standards in structural analysis Significant effort has ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Biocatalytic production of precursors to lutein and zeaxanthin to address age related macular degeneration

    SBC: EscaZyme Biochemicals, LLC            Topic: N

    Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Development of a protein drug for pancreatic cancer treatment

    SBC: ProDa BioTech L.L.C.            Topic: NCI

    Abstract Pancreatic cancers are devastating diseases with five year survival rate less than Currently there is no effective treatment for advanced disease One major barrier to efficacy of anti tumor therapeutics is the dense desmoplastic stromal response Evidence suggests that cancer associated pancreatic stellate cells CAPaSC produce the stromal collagen The ECM laid down by CAPaSC is c ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Bayesian Inference of Spacecraft Geometry and Pose

    SBC: VISION SYSTEMS INC.            Topic: AF17AT007

    Space platforms are complex dynamical systems and there are many reasons to model them from ground telescope imagery as well as from space-based sensor platforms. One key motivation is to determine the operational state and configuration of the vehicle. Key questions such as did the solar panels fail to deploy, did the object begin to tumble unexpectedly may be addressed by a sufficiently detaile ...

    STTR Phase I 2017 Department of DefenseAir Force
  10. OC Go Facilitating fidelity and dissemination of evidence based treatment for childhood OCD via an interactive crowd sourced patient provider tool

    SBC: VIRTUALLY BETTER INC            Topic: 104

    Project Summary OC Go Facilitating fidelity and dissemination of evidence based treatment for childhood OCD via an interactive crowd sourced patient provider tool The long term objective of this project is to leverage mobile technologies and crowdsourcing to create a new paradigm of evidence based treatment delivery and dissemination as current methods are often insufficient The project seeks ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
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