Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Biocatalytic production of precursors to lutein and zeaxanthin to address age related macular degeneration

    SBC: EscaZyme Biochemicals, LLC            Topic: N

    Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Hyperphosphorylated tau aggregation kit to identify tauopathy risk factor

    SBC: CAYMAN CHEMICAL COMPANY, INCORPORATED            Topic: NIA

    PROJECT SUMMARY Millions of Americans are suffering from the devastation of cognition decline and other neurological dysfunctions due to one of the neurodegenerative diseases of tauopathy Some of the prominent tauopathies include Alzheimer s disease Pick s disease traumatic brain injury and chronic encephalopathy There is no cure for any of the tauopathies and the actual cause or exogenous r ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Fc folate Conjugate for the Treatment of Triple Negative Breast Cancer

    SBC: NeuLink Inc.            Topic: 100

    Abstract According to the American Cancer Society in women in the U S will develop breast cancer at some point in their life and of these women will have triple negative breast cancer TNBC an aggressive subtype of breast cancer that lacks the three receptors ER PR HER that current drug treatment targets tamoxifen Herceptin Because of its aggressive nature and lack of effec ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Ground state rabbit pluripotent stem cells

    SBC: ATGC Inc.            Topic: OD

    Abstract To evaluate the therapeutic applications of stem cells it is essential to develop translational research using several animal species Rabbit is a useful model for biomedical research It has been used to study a number of human diseases Compared to mice rabbits have a more similar embryology and stem cell biology to those of humans an adult body size comparable to human infants that ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Bayesian Inference of Spacecraft Geometry and Pose

    SBC: VISION SYSTEMS INC.            Topic: AF17AT007

    Space platforms are complex dynamical systems and there are many reasons to model them from ground telescope imagery as well as from space-based sensor platforms. One key motivation is to determine the operational state and configuration of the vehicle. Key questions such as did the solar panels fail to deploy, did the object begin to tumble unexpectedly may be addressed by a sufficiently detaile ...

    STTR Phase I 2017 Department of DefenseAir Force
  6. A nanoparticle delivery system for CRISPR Cas based therapeutics

    SBC: ATGC Inc.            Topic: NCATS

    Abstract Applications of customizable nucleases such as CRISPR clustered regularly interspaced short palindromic repeats Cas CRISPR associated protein have enabled efficient and precise gene correction in vitro and hold promises for eventually achieving in vivo gene correction therapy However to apply CRISPR Cas in therapeutic settings several major challenges remain to be addressed ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Novel methods to improve nuclease mediated homologous recombination

    SBC: ATGC Inc.            Topic: NIGMS

    Abstract Gene correction therapy is one of the most important application directions in regenerative medicine Emerging technologies such as CRISPR clustered regularly interspaced short palindromic repeats Cas CRISPR associated protein Zinc Finger Nuclease ZFN and Transcription Activator Like Effector Nuclease TALEN have enabled efficient and precise gene editing in a wide spectrum of ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Development of MTX for the Treatment of KRAS Mutant Colorectal Cancer

    SBC: Mekanistic Therapeutics, LLC            Topic: NCI

    PROJECT SUMMARY Mekanistic Therapeutics seeks to design discover and develop anti cancer agents that selectively inhibit multiple oncogenic pathways Its lead agent MTX was discovered in collaboration with the Leopold laboratory at University of Michigan MTX is a novel kinase inhibitor showing early promise for its therapeutic potential against solid cancers refractory to current treatm ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Flexible Smart Sensor Network for Structural Health Monitoring

    SBC: VIRTUAL EM INC.            Topic: AF16AT03

    Virtual EM INC. in collaboration with Case Western Reserve University (CWRU) proposes to develop a highly expandable, lightweight and flexible sensor network for structural health monitoring (SHM) by directly addressing the roadblocks of high size, weight, and power requirements and high communication bandwidth. CWRU has recently advanced the state-of-the-art by developing and testing a custom fr ...

    STTR Phase I 2017 Department of DefenseAir Force
  10. Family Supportive Supervisor Training and Workplace Assessment Tool

    SBC: WORK LIFE HELP, INC.            Topic: NIA

    DESCRIPTION provided by applicant Managing the demands of work and personal life is a major stressor affecting employees yet there are virtually no evidence based workplace supervisory training interventions to address this critical public health concern Research has shown work family conflict can affect employeesandapos health workplace productivity family interactions and safety and wel ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
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