Award Data

Project Summary / Abstract: COVID-19, the clinical presentation associated with SARS-CoV-2 infection, has already profoundly impacted healthcare systems globally. Of particular note, communities such as long-term care facilities, assisted living communities, and prisons, are being devastated because of their high density of vulnerable individuals. Nursing home residents, which represent only 0.5% ...

Executive Summary of Predicate (One Page) Summary of Specific Aims of Phase I Specific Aim 1: Train and evaluate an algorithm to detect pediatric asthma symptoms (cough and wheeze) on a low power, small form factor wearable device. Specifications: 90% sensitivity; false alarm rate: 1 cough episode/day or 1 wheeze episode/day. Evaluate algorithm against medical expert (physician) scoring using the ...

Major depressive disorder is a debilitating mood disorder that affects ~7% of US adults in their lifetime, costing the U.S. economy more than $200 billion a year. Drugs that increase monoaminergic signaling are the mainstay of depression therapy, but have a delayed onset of action and are only effective in about 50% of affected patients. Aberrant brain-derived neurotrophic factor (BDNF) signaling ...

ABSTRACT The primary objective of surgical therapy for the treatment of patients with any cancer is to remove all cancer cells from within the bodywith the secondary objective of maintaining organ functionThe primary pathological metric used to rate the success of a surgical procedure is evaluation of the surgical margin of the resected tissue specimenpost operativelyThis typically involves cuttin ...

Project Summary Abstract Millions of people in the US misuse opioids each yearleading to thousands of deaths and costing billions of dollars in total economic burdenMedication assisted treatmentMATfor opioid use disorderOUDis highly efficaciousbut only a fraction of OUD persons access MATand treatment non adherence is common and associated with poor outcomesThis STTR Fast Track proposal is designe ...

Project Abstract The opioid epidemic is the U S andapos s most widespread behavioral public health problemwith a higher number of deaths due to drug overdose incompared to deaths due to HIV at the peak of the AIDS epidemicMedication assisted treatmentMATfor opioid use disorderOUDis highly efficaciousHoweveronly a fraction of persons with OUD access MATand treatment non adherence and drop out is co ...

Project SummaryNovel High Resolution Scintillation X ray Detectors for Digital Dentistry The transition from traditional film to digital X ray detectors has resulted in significant improvements across many areas for dental X ray imaging ranging from decreased wait timesimproved logistics and even lower radiation dose ratesOne significant drawback remains with digital X ray imaging howeverwhich is ...

PROJECT SUMMARY ABSTRACTUltrasound isand is poised to remaina ubiquitous biomedical imaging modalityIt is safefasteffectiveand affordableUltrasound imaging innovations are being actively developed to provide inexpensive solutions to public health concerns in areas as diverse as early cancer detectiontargeted drug deliveryand image guided surgeryYet significant barriers to research and innovation i ...

PROJECT SUMMARY ABSTRACT Clinical NeedThe coming decades promise a revolution in the therapies available for patients with generalized neuromuscular diseasesGNMDsincluding muscular dystrophyamyotrophic lateral sclerosisspinal muscular atrophymyasthenia gravisand a variety of acquired myopathiesHoweverin order to help facilitate thisthe academic and industrial clinical research communities need imp ...

Proposed herein are novel design methodologies to create sensors for chemical, biological, radiological, nuclear and/or explosive (CBRNE) detection aboard a Small Unmanned Aerial System (SUAS), as well as intelligent Bayesian-based plume analysis and source detection algorithms that offer capabilities for the Air Force above and beyond the state of the art. The assembled technical team of experts ...