Award Data

Chronic musculoskeletal pain creates a significant public health burden, and Veterans are disproportionately affected. The frequency and extent of co-occurrence of pain and PTSD, pain and Traumatic Brain Injury (TBI), all three conditions (Post-deployment Multi-symptom Disorder (PMD), and other multi-symptom syndromes can complicate and reduce the effectiveness of pain treatment. Furthermore, the ...

Project summaryAbout five million patients currently suffer from heart failureHFin the USresulting in about one million hospitalizations annually and a yearly cost of andgtbillion USDThe long term objective of this project is to develop an innovative technology to assist HF outpatient managementThe proposed device will be used by health care providers to detect HF deteriorationwhich may facilitate ...

Sepsis induced ALI ARDS is a devastating syndrome of acute respiratory failure in critically ill patients that accounts for among the highest admission rates in ICU and mortalityDuring STTR Phasewe at Cell Biologics Incdemonstrated that piceatannola naturally occurring anti inflammatory that selectively inhibits Syk tyrosine kinasewhen entrapped in innm albumin nanoparticlesPANPswas therapeuticall ...

Abstract There has been considerable excitement about the potential for technology to help overcome many of the access barriers to treatment for mental health problemsWhile a large number of randomized controlled trials have demonstrated the potential efficacy of these interventionsattempts to implement and sustain these tools in care and service settings has proven challengingThis project will op ...

There is a fundamental knowledge gap in how to immediately reduce cancer patientstreatment related financial burdenCancer patients pay more out of pocket for their care than those with other chronic illnessesHalf of all elderly cancer patients have high treatment related out of pocket financial burdenThis financial burden has well defined harmful effects even among insured cancer patients includin ...

The result of this project will be the integration of the advanced, high-fidelity physics-based hydrocode, EPIC, into the DoDs Modular Effectiveness Vulnerability Assessment (MEVA) code. This will be accomplished by integrating a flexible, open-source, application integration infrastructure called IMPACT, developed and supported by Illinois Rocstar, into Endgame Framework.To address the need for h ...

PROJECT SUMMARY DR is a secondary complication of diabetes and a leading cause of blindness in the world Although it is well known that DR is driven by ischemia the current grading of DR severity is based only on structural alterations such as the presence of abnormal retinal microvasculature in non proliferative DR and angiogenesis in proliferative DR As a result when their diagnosis is first ...

DESCRIPTIONprovided by applicantThe Cell SafeTM is a fundamentally new approach in replacement of dysfunctional insulin producing cells in patients with diabetesby transplantation of new islets in a three dimensional scaffold embedded in a highly compatible bioengineered perfusion system that continuously supplies tissue fluidblood ultrafiltrateso that the cells ae protected from immune rejection ...

ABSTRACT Alzheimerandapos s and other tauopathies are medical problems growing to historical proportions that threaten the long term viability of medical care systems world wide Alzheimerandapos s costs today are of the US GDP and growing as the population ages Effective disease modifying treatments have yet to be developed A number of drugs in clinical testing target amyloid but very fe ...

The World Health Organization estimates that bymajor depressive disorderMDDwill be the most common cause of disabilityworldwideAlthough approximatelyinAmericans will suffer from MDD during their lifetimemany patients with MDD go undiagnosed in primary care settingsandare incorrectly diagnosed with MDDGiven the substantial medicaleconomic and social costs involved with MDDthere is tremendous need f ...