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A cerebral aneurysm is an abnormal enlargement or pouch that forms from a weakened vessel segment in the brain Often going unnoticed and untreated an aneurysm can cause a sudden and catastrophic hemorrhage or stroke Approximately of patients die from an aneurysm rupture even before receiving medical attention and of patients die despite medical treatment Patients that survive typical ...

PROJECT SUMMARY Chemotherapy induced peripheral neuropathy CIPN is a common prevalence and potentially dose limiting side effect of many cancer chemotherapy drug treatment regimens Clinically CIPN presents with pain that is burning shooting or electric shock like The increase in prevalence of cancer coupled with an increase in the cancer survival rates due to chemotherapy regimens ...

This proposal aims to develop a polymer hydrogel strategy that can be used to improve the clinical care of patients receiving brachytherapy for gynecological cancers The biocompatible hydrogel will form in situ after being injected into the vaginal space and later removed by instillation of water to soften the hydrogel for easy extraction This Phase I proposal focuses on optimizing the polymer ...

Project Summary Glioblastoma GBM is one of the most lethal incurable human diseases Even with aggressive therapies including surgical resection followed by radiotherapy and chemotherapy using temozolomide TMZ the median survival for GBM patients is only months In fact GBM cancer cells are highly infiltrative and comprise a sub population of glioma stem cells GSCs with tumorigenic pro ...

Project Summary Many clinical and preclinical studies demonstrated that interferons IFNs exert a superior anti tumor effect when combined with retinoids a class of vitamin A metabolites We identified a novel tumor suppressor Gene associated with Retinoid IFN induced Mortality GRIM by a genome wide knockdown strategy In our recent publication in the PNAS we have shown that GRIM g ...

The long term objective of this project is the synthesis and assembly of wound healing devices that mimic as closely as possible the biochemical and mechanical characteristics of healthy human skin The proposed research would focus on the synthesis of membranes containing electrospun human recombinant tropoelastin and collagen mixtures The ratios of the two molecules and the spinning condition ...

Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...

Abstract This Phase I application aims to determine the feasibility of using lipid enhanced nanosensor LENS arrays for smart phone based detection of lead Pb and mercury Hg in drinking water at concentrations above FDA allowable levels LENS arrays are composed of fluid lipid multilayer diffraction gratings on surfaces The fluid nature of these arrays has two advantages reagents can ...

PROJECT SUMMARY ABSTRACT Breastfeeding has the potential to reduce health disparities associated with infant mortality and morbidity Breastfeeding rates by ethnicity in the United States show a marked disparity in African American AA women as compared to other groups Barriers to breastfeeding are complex with literature citing a lack of knowledge poor family and social support inhibiting soc ...

The purpose of this proposed research is to develop and commercialize a novel two color sodium guidestar laser operating simultaneously at 589 nm and 1141 nm. Our patented T-cavity design combined with VECSEL technology will be the basis for the guidestar development. The polychromatic laser guidestar (PLGS) system being proposed currently does not exist and would allow for the correction of atmos ...