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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Peripheral FAAH as a target for novel analgesics

    SBC: Anteana Therapeutics Inc            Topic: NIDA

    DESCRIPTIONprovided by applicantPain management is a significant unmet medical needAnandamide is an endocannabinoid mediator that plays important roles in the regulation of painPrevious work has shown that endocannabinoid receptors located outside the central nervous systemCNSexert a powerful regulatory control over pain initiationThe biological actions of anandamide are stopped by the enzymefatty ...

    STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Comprehensive Glycoproteomic Tool Development for Cancer Biomarkers

    SBC: Protein Metrics Inc.            Topic: 400

    Project SummaryGlycosylation is one of the most prevalent and important post translational modifications of proteinsyet it is also one of the most difficult to studyNo single method nor analytical platform can give complete information about the glycosylation in a protein sampleand the analytical methods in current use include both ESI and MALDI single and tandem mass spectrometryat least four typ ...

    STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Augmenting Dual Energy CT for Novel Contrast Agents

    SBC: NEXTRAST, INC            Topic: 300

    Project SummaryAbstract Our long term goal is to revolutionize the effectiveness of CT imaging for millions of Americans across a broad range of abdominal diseaseDual energy CTDECTprovides powerful clinical diagnostic potential but remains heavily underutilized despite wide scanner availabilityDECT allows materials to be differentiated based on their relative X ray attenuation at low versus high e ...

    STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Integrated Fiber-Optic Sensor Reliability Modeling and Analysis Tools for Thermal and Power Management Systems for Gas Turbine Engines

    SBC: Intelligent Fiber Optic Systems Corporation            Topic: AF16AT16

    Addressing a key technology gap in deployment of fiber-optic sensor networks, IFOS and multidisciplinary collaborators are developing an integrated fiber-optic component reliability modeling software toolkit. The RelOptics toolkits analytical engine is based upon predictive failure models developed for the first time in aerospace industry via rigorous environmental testing of optical fiber splices ...

    STTR Phase II 2017 Department of DefenseAir Force
  5. Intelligent and Multiplexable Ultra-High Temperature Fiber Optic Pressure Sensors for Robust Distributed Engine Control

    SBC: Intelligent Fiber Optic Systems Corporation            Topic: AF16AT18

    Engines will be getting smaller and hotter for efficiency reasons, requiring novel sensors with extended and enhanced performance. Emerging fiber-optic sensing approaches could provide a unique solution to the widening technology gap between next-gen engine requirements and conventional sensors limited capabilities. The overall objective of this program is to develop techniques to integrate new pr ...

    STTR Phase II 2017 Department of DefenseAir Force
  6. Hypersonic Experimental Aerothermoelastic Test (HEAT)

    SBC: Global Aerospace Corporation            Topic: AF16AT24

    The U.S. Air Force is interested in developing hypersonic vehicles including reusable transport aircraft, cruise missiles, and unmanned systems. Hypersonic flight regimes result in multifaceted and very difficult design challenges that can be encapsulated into an aerothermoelastic problem, which is a complex interaction of structural, thermal, and aerodynamic mechanisms. When a flexible structural ...

    STTR Phase II 2017 Department of DefenseAir Force
  7. Automated Electrophysiology Assessment of Drug induced Cardiotoxicity Based on Parallel Noninvasive Nanoelectrode Array

    SBC: CYION TECHNOLOGIES LLC            Topic: NIBIB

    Summary Drug safety issues pose a serious challenge to the health and well being of patients The development of our innovative technology aims to address a significant gap in the in vitro assessment of drug induced cardiotoxicity which is the number one reason for withdrawals of all marketed drugs as well as the premature termination of promising drug development candidates Pressured by the eno ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Recyclable Magnetic Co C Hybrid ROMP Reagents Scavengers and Ligands

    SBC: MATERIA, INC.            Topic: 300

    DESCRIPTION provided by applicant This Fast Track Small Business Technology Transfer study between Materia Inc in Pasadena CA and the University of Kansas intends to build upon successes of our current Phase II Fast Track STTR grant R GM which ends on March Preliminary results serve as a solid foundation for this Fast Track submission entitled andquot Development of Re ...

    STTR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  9. Skin Microbiome Editing with Fermentation Initiator

    SBC: Surface Bioadvances, Inc.            Topic: NIAMS

    Abstract Acne dysbiosis is defined as microbial imbalance with the over growth of Propionibacterium acnes P acnes in the acne microbiome We have demonstrated that Staphylococcus epidermidis S epidermidis a probiotic bacterium co existed with P acnes in an acne lesion can exploit the carbohydrate fermentation to produce short chain fatty acids SCFAs and rein in the over growth of P ac ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Novel Treatment for Traumatic Brain Injury

    SBC: Epigen Biosciences, Inc.            Topic: 101

    SUMMARY Traumatic brain injury TBI is a leading contributor to death and disability in the USA yet widely effective treatments remain elusive and except for a lengthy program of rehabilitation no effective treatment for TBI is available Therefore there is a critical need in new therapeutic approaches which can maximally preserve brain tissue and facilitate functional recovery after TBI In ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
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