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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Multiscale Simulation Framework for Modeling of Structural Reactive Materials

    SBC: WASATCH MOLECULAR, INC.            Topic: AF16AT23

    We propose to develop a set of multiscale modeling tools for structural reactive materials (SRMs) that explicitly treat microscale, mesoscale and macroscale coupling of mechanical response, thermal properties and chemical reactions. At the macroscale, a combined material point method (MPM, solid)/Eulerian (ICE, fluid) methodology, MPM-ICE, will be employed to investigate the behavior of select int ...

    STTR Phase II 2017 Department of DefenseAir Force
  2. Prediction and Measurement of the Soot Build-Up in Film-Cooled Rocket Engines

    SBC: JOHNSON ROCKETS            Topic: AF15AT21

    This Phase II STTR effort is focused on generating the data necessary to identify the phenomenology that produces carbon deposition within kerosene film cooled rocket engines.This data is essential to guide the model development and validation process.Program outputs will be both data and a physics-based model for carbon deposition.

    STTR Phase II 2017 Department of DefenseAir Force
  3. Visually driven disease variant analysis empowering real time clinical research

    SBC: Frameshift Labs, Inc.            Topic: NHGRI

    Project Summary Identifying disease causing genetic variants is a complex process that requires experts from multiple fields including bioinformatics IT systems administration and disease pathology to work closely together The size of sequencing data files also adds the requirement for large computational resources As a result performing genomic analyses is an ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Biocatalytic production of precursors to lutein and zeaxanthin to address age related macular degeneration

    SBC: EscaZyme Biochemicals, LLC            Topic: N

    Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Bayesian Inference of Spacecraft Geometry and Pose

    SBC: VISION SYSTEMS INC.            Topic: AF17AT007

    Space platforms are complex dynamical systems and there are many reasons to model them from ground telescope imagery as well as from space-based sensor platforms. One key motivation is to determine the operational state and configuration of the vehicle. Key questions such as did the solar panels fail to deploy, did the object begin to tumble unexpectedly may be addressed by a sufficiently detaile ...

    STTR Phase I 2017 Department of DefenseAir Force
  6. Optimization of an integrin enhancing molecule for the treatment of Duchenne muscular dystrophy

    SBC: STRYKAGEN CORPORATION            Topic: NIAMS

    DESCRIPTION provided by applicant Duchenne muscular dystrophy is caused by mutations in the dystrophin gene resulting in the loss of the dystrophin glycoprotein complex in skeletal muscle Loss of dystrophin results in reduced sarcolemmal integrity progressive muscle damage and compromised muscle function There is currently no cure and limited treatment options for DMD and all affected child ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  7. An MPM-based Multiscale Framework for Simulations of Mesoscale Heterogeneous PBXs

    SBC: WASATCH MOLECULAR, INC.            Topic: AF15AT28

    ABSTRACT: We will develop a multiscale molecular dynamics/material point method (MD/MPM) methodology for determining the response of PBXs to a wide range of loading conditions as a function of mesoscale structure with emphasis on accurate representation of interfacial physics. The initial material of choice will be HMX + DOA plasticized HTPB binder. Velocity-dependent grain-grain and viscoelastic ...

    STTR Phase I 2015 Department of DefenseAir Force
  8. Rapid Monitoring and Assessment of Tubercuolosis Treatment at the Point of Care Using Breath

    SBC: NanoSynth Materials and Sensors Inc.            Topic: NHLBI

    DESCRIPTION provided by applicant Problem and Significance According to the CDC global statistics nearly of the world is infected with Tuberculosis TB In million f peopled infected lived in what is considered a high burden country Countries such as India Peru China sub Saharan Africa and others have significant regions endemic for TB particularly among the lower income ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  9. Backbone Degradable Polymer-drug Conjugates for the Treatment of Ovarian Cancer

    SBC: TheraTarget, Inc.            Topic: NCI

    DESCRIPTION provided by applicant The purpose of this Phase II STTR project is to develop a polymeric system for the combination delivery of two antineoplastic agents gemcitabine and paclitaxel Based on the successful results of the STTR Phase I award this Phase II proposal details the rationale and research plan for the synthesis and evaluation of in vivo efficacy of two novel macromolecula ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Galectin 1: A novel small protein therapy for Duchenne muscular dystrophy

    SBC: STRYKAGEN CORPORATION            Topic: NIAMS

    DESCRIPTION provided by applicant Duchenne Muscular Dystrophy DMD is a fatal muscle disease affecting in every male births DMD results from mutations in the gene encoding the dystrophin a kDa scaffolding protein responsible for providing a mechanical link between the muscle fiber actin cytoskeleton and a transmembrane protein complex called the dystrophin associated glycoprotein ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
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