Award Data

Neonatal hypoxia ischemiaHIremains a major cause of acute perinatal brain injuryleading ultimately to neurologic dysfunction manifesting as cerebral palsymental retardationand epilepsyUnfortunatelycurrent treatment and prevention strategies in newborns are limitedThere are no currently available therapies to prevent treat and or attenuate brain damage in premature infants other than supportive car ...

More thanU Spatients have end stage renal disease and overutilize hemodialysis as their renal replacement modality of choiceThe Achilles Heel in the care of dialysis patients is the development of a functioning and durable vascular accesspreferably an arteriovenous fistulaAVFThe annual cost of treating vascular access dysfunction totals over one billion US dollarsThis is largely due to the high pr ...

This project will develop design fabricate test and demonstrate a novel SmartPlate Technology for Advanced Cell based Models STAC M The STAC M technology will be demonstrated for both current static culture and next generation cell based assays The proposed effort features a collaboration between CFD Research Corporation and Vanderbilt University and builds on several critical element ...

Chronic musculoskeletal pain creates a significant public health burden, and Veterans are disproportionately affected. The frequency and extent of co-occurrence of pain and PTSD, pain and Traumatic Brain Injury (TBI), all three conditions (Post-deployment Multi-symptom Disorder (PMD), and other multi-symptom syndromes can complicate and reduce the effectiveness of pain treatment. Furthermore, the ...

GasTOPS will further improve ChipCHECK through modifications beneficial to the USAF Oil Analysis Program (OAP) to include meeting the performance objectives for Analytical Chip Debris Classification (ACDC) identified in FA8650-17-C-2007 Attachment 1, Statement of Objectives. USAF’s specified alloy identification library will be created as well as desired interfaces to enable user-friendly s ...

ABSTRACTEndotoxin neutralization in human plasma is an excellent indicator of chronic immune activationwhich is an accurate predictor of mortality in HIVinfectionRecently we developed an assay using endotoxin neutralization as an indicator of immune activation due to bacterial translocationThis assay is accurate in discriminating healthy patients from those with inflammatory bowel disease in addit ...

DiscoveryBioMedIncDBMIncor DBMspecializes in normal and diseased human cell platform engineeringDBM has assembled a consortium of expertswherebycollectivelywe seek Fast Track SBIR funding to establish and offer a Product Line Menu of normal and ADPKD human cell platforms for the academic and industry marketplacesExisting and interested DBM clients will be presented in terms of which options in the ...

Designing an efficient and effective film cooling system to protect critical components of modern rocket engines requires a significant number of problems and challenges to be addressed. Complicating the already difficult hydrodynamic challenges, thermal and/or catalytic cracking of hydrocarbon fuels is always accompanied with coke formation. Coke deposits on combustor and nozzle walls reduce heat ...

The objective of the proposed Phase II effort is to establish fundamental understanding of combustion-physical mechanisms leading to blowout, the critical evaluation of model limitations in predicting these blowout processes and the development of an improved combustion model to enable the prediction of lean blowout (LBO) in swirl-stabilized combustors. For this, high-resolution numerical simulati ...

Leveraging the results of our Phase I work, the Torch Team proposes to develop a multi-camera system with associated Background-Oriented Schlieren 3D (BOS-3D) algorithms to track and characterize blast waves from detonating weapons in an arena test enviro