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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Aerosolized platinum nanoparticle chemotherapy for lung cancer

    SBC: HYLAPHARM LLC            Topic: 102

    Significance Lung cancer is the leading cause of cancer deaths with over new diagnoses annually Survival rate of lung cancer patients is correlated with the extent of lymph node metastasis Standard care includes chemotherapy radiation and or surgery Cisplatin is a first line chemotherapy for lung cancer but systemic intravenous IV delivery is confounded by various toxicities rena ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Biocatalytic production of precursors to lutein and zeaxanthin to address age related macular degeneration

    SBC: EscaZyme Biochemicals, LLC            Topic: N

    Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Developing Testing and Validating a Wearable Alcohol Biosensor

    SBC: Clinitech, LLC            Topic: 450

    PROJECT SUMMARY This application for a Phase I SBIR award represents a collaboration between Clinitech LLC and McLean Hospital Harvard Medical School to develop a wearable biosensor for detecting alcohol in the interstitial fluid of humans who have consumed alcohol Excessive use of alcohol accounts for much of the public health burden related to alcohol use disorders including fetal ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Precision Microspheres for Transtympanic Delivery of Ganciclovir for CMV Infection

    SBC: ORBIS BIOSCIENCES, INC.            Topic: Y

    PROJECT SUMMARY Current approaches to treat sensorineural hearing loss SNHL in newborns suffering from congenital cytomegalovirus CMV infection rely on off label systemic antiviral therapy requiring high dose long duration treatment with demonstrated hematologic toxicity carcinogenicity and teratogenicity Furthermore it is unknown whether systemic delivery of antivirals maintain inner e ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Low cost portable system for the rapid detection and drug resistance profiling of Tuberculosis in low resource environments

    SBC: Impedx Diagnostics Inc.            Topic: NICHD

    Tuberculosis TB is one of the major public health challenges in the world today with an estimated million deaths in More alarmingly the incidence of multi drug resistant MDR TB is rapidly increasing especially in low resource environments The goal of this project is to develop an inexpensive portable system and method using which it will be possible to both detect the presence of ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. GENERATING SYNERGY BETWEEN PROTEIN AND NON PROTEIN MACROMOLECULAR ADJUVANTS

    SBC: Hafion LLC            Topic: NIAID

    The Contractor will examine the additive and potentially synergistic activities of two potential adjuvants as a combined adjuvant low molecular weight hyaluronan Haf and the A subunit of the Escherichia coli heat labile enterotoxin LTA The adjuvants will be examined in the context of protection against Bordetella pertussis the causative agent of pertussis whooping cough

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Automatic Dependent Surveillance- Broadcast (ADS-B) and UAS operations

    SBC: KALSCOTT ENGINEERING INC            Topic: AF171045

    A full-featured ADS-B unit for unmanned air vehicles is proposed. In addition to the ADS-B In/Out capability, several features which are customized for UAV operations are included. In Phase I, development of the features will be undertaken, along with pre

    SBIR Phase I 2017 Department of DefenseAir Force
  8. Synthesis of HAN and HEHN in a Continuous Mix Process

    SBC: Digital Solid State Propulsion, Inc            Topic: AF171061

    Production of hydroxylamine nitrate (HAN) and hydroxyethyl hydrazine nitrate (HEHN) is of great concern for the manufacture of AF-315E. Current stockpiles of heritage ingredients held by AFRL are being depleted and those manufacturers are no longer in exi

    SBIR Phase I 2017 Department of DefenseAir Force
  9. Prediction and Measurement of the Soot Build-Up in Film-Cooled Rocket Engines

    SBC: JOHNSON ROCKETS            Topic: AF15AT21

    This Phase II STTR effort is focused on generating the data necessary to identify the phenomenology that produces carbon deposition within kerosene film cooled rocket engines.This data is essential to guide the model development and validation process.Program outputs will be both data and a physics-based model for carbon deposition.

    STTR Phase II 2017 Department of DefenseAir Force
  10. Bayesian Inference of Spacecraft Geometry and Pose

    SBC: VISION SYSTEMS INC.            Topic: AF17AT007

    Space platforms are complex dynamical systems and there are many reasons to model them from ground telescope imagery as well as from space-based sensor platforms. One key motivation is to determine the operational state and configuration of the vehicle. Key questions such as did the solar panels fail to deploy, did the object begin to tumble unexpectedly may be addressed by a sufficiently detaile ...

    STTR Phase I 2017 Department of DefenseAir Force

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